User:Tkadm30/Notebook/EGFR: Difference between revisions
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=== Glossary === | |||
* cytotoxic: toxicity factor to cells | |||
* cytoplasm: outer edge of the cell membrane | |||
* oxidative phosphorylation: a enzymatic reaction converting energy from phosphate cleaving molecules to ATPase and NADPH substrates. | |||
* Fyn: A cell-depend tyrosine kinase ligand associated to the Fyn oncogene | |||
* Src: SH Homology domain (a tyrosine kinase protein adaptor associated to the EGFR gene) | |||
* tyrosine kinase: a tyrosine bound protein substrate member of the kinase super family of protein kinases | |||
=== Case studies === | === Case studies === |
Revision as of 17:36, 10 May 2012
EGF(R)-mediated drug delivery
- First please see this paper for background info on EGF(R) targeting here.
- The aim of this wiki document is to review the characterization of cancerogenic mutations occuring in multiple receptor-associated tyrosine kinase proteins targeting the EGF receptor and perhaps cholesterol based lipid rafts including stearic acid (monosaturated) and in fatty acids derived ligands.
Glossary
- cytotoxic: toxicity factor to cells
- cytoplasm: outer edge of the cell membrane
- oxidative phosphorylation: a enzymatic reaction converting energy from phosphate cleaving molecules to ATPase and NADPH substrates.
- Fyn: A cell-depend tyrosine kinase ligand associated to the Fyn oncogene
- Src: SH Homology domain (a tyrosine kinase protein adaptor associated to the EGFR gene)
- tyrosine kinase: a tyrosine bound protein substrate member of the kinase super family of protein kinases
Case studies
Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted (Fyn/Src) phosphorylation
Selected readings:
- Epithelial Stem Cells: Turning over New Leaves (Rockefeller University)
Fyn (Src) lipid based drug delivery and breast cancer: Chemtrails as potentially harmful cancerogenic agents?
Notes:
- Receptor-associated tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes?
- Calmodulin-dependent protein kinase receptors (Ca2+) signal transduction linked to Alzheimer like neuronal dysregulation? (ie: PH based phospholipid dysregulation) ?
- Endocannabinoids: Wet Blanket on Hippocampus Excitement
- Hippocampus dysregulation from calcium-dependent lipid-like signaling networks?
- Etienne Robillard 08:56, 4 May 2012 (EDT): 420 like (CB1 receptors) to the rescue..? :)
- In other words, how can anandamide (endocannabinoids) be used as novel therapeutic to mediates neuronal dysregulation of the hippocampus and in particular breast cancer early cancerogenic mutations ?
- Question: Is AChe dependent protein binding from endocannabinoid-specific activation (CB1-associated?):
- Endocannabinoid-specific receptors preventing beta amyloid precursors (β-amyloid peptide (Aβ)) aggregating in lipid rafts from cell-protein (AChe) promoted binding site(s), thus autocleaving phospholipid residues from oxidative radicals ? (gp42 link?)
- Question: How can tyrosine kinase derived substrates (from enzymatic reactions in C-domain (SH2) and N-domain (SH3)) can have a orthogonal role in Alzheimer pathogenesis and in targeted drug delivery?
- Answer: As emerging hypothesis, phosphorylation-induced tyrosine kinase drug delivery and upregulation to epithelial stem cells may probably result in asymmetrical protein binding in cholesterol-based microdomains (lipid rafts) with ErbB specific ligands, thus triggering a signal transduction cascade from the activated Src/Fyn receptors.
- Hippocampus dysregulation from calcium-dependent lipid-like signaling networks?
TODO
- Is programmed cell-death from cell-specific DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ?
- Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR)
- On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of concentrating receptors, the lipids and lipid tethered proteins together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html)
- Is the p53 gene dependent on genetical inheritance (DNA-protein interactions) to make epithelial stem cells vulnerable to cancerogenic mutations ?
Keywords
Src homology domains, SH2, SH3, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy)
References
-
C. Branden, J. Tooze, "Introduction to protein structure", [270-279]