User:Etienne Robillard/Notebook/EGFR

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* Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
* Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
** [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408375/ Epithelial Stem Cells: Turning over New Leaves] (Rockefeller University)
** [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408375/ Epithelial Stem Cells: Turning over New Leaves] (Rockefeller University)
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* '''Receptor-associated''' tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes?
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** '''Receptor-associated''' tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes?
** Calmodulin-dependent protein kinase receptors (Ca2+) signal transduction linked to Alzheimer like neuronal dysregulation? (ie: PH based phospholipid dysregulation) ?
** Calmodulin-dependent protein kinase receptors (Ca2+) signal transduction linked to Alzheimer like neuronal dysregulation? (ie: PH based phospholipid dysregulation) ?
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* [http://www.alzforum.org/new/detail.asp?id=1446 Endocannabinoids: Wet Blanket on Hippocampus Excitement]
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** [http://www.alzforum.org/new/detail.asp?id=1446 Endocannabinoids: Wet Blanket on Hippocampus Excitement]
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** '''Hippocampus''' dysregulation from calcium-dependent '''lipid-like''' signaling networks?  
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*** '''Hippocampus''' dysregulation from calcium-dependent '''lipid-like''' signaling networks?  
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*** [[User:Etienne Robillard|Etienne Robillard]] 08:56, 4 May 2012 (EDT): 420 like (CB1 '''receptors''') to the rescue..? :)
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**** [[User:Etienne Robillard|Etienne Robillard]] 08:56, 4 May 2012 (EDT): 420 like (CB1 '''receptors''') to the rescue..? :)
 +
**** In other words, how can '''anandamide''' (endocannabinoids) be used as novel therapeutic to mediates neuronal dysregulation of the hippocampus and in particular breast cancer early cancerogenic mutations ?
== TODO ==
== TODO ==

Revision as of 08:44, 5 May 2012

Contents

EGF(R)-mediated drug delivery

  • First please see this paper for background info on EGF(R) targeting here.
  • The aim of this wiki document is to review the characterization of cancerogenic mutations occuring in multiple receptor-associated tyrosine kinase proteins targeting the EGF receptor and perhaps cholesterol based lipid rafts including stearic acid (monosaturated) and in fatty acids derived ligands.


Case studies

  • Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
    • Epithelial Stem Cells: Turning over New Leaves (Rockefeller University)
    • Receptor-associated tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes?
    • Calmodulin-dependent protein kinase receptors (Ca2+) signal transduction linked to Alzheimer like neuronal dysregulation? (ie: PH based phospholipid dysregulation) ?
    • Endocannabinoids: Wet Blanket on Hippocampus Excitement
      • Hippocampus dysregulation from calcium-dependent lipid-like signaling networks?
        • Etienne Robillard 08:56, 4 May 2012 (EDT): 420 like (CB1 receptors) to the rescue..? :)
        • In other words, how can anandamide (endocannabinoids) be used as novel therapeutic to mediates neuronal dysregulation of the hippocampus and in particular breast cancer early cancerogenic mutations ?

TODO

  • Is programmed cell-death from cell-specific DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ?
  • Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR)
  • On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of concentrating receptors, the lipids and lipid tethered proteins together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html)
  • Is the p53 gene dependent on genetical inheritance (DNA-protein interactions) to make epithelial stem cells vulnerable to cancerogenic mutations ?

Keywords

Src homology domains, SH2, SH3, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy)

References

  1. C. Branden, J. Tooze, "Introduction to protein structure", [270-279] [1998]
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