User:Tkadm30/Notebook/EGFR: Difference between revisions

Revision as of 07:30, 4 May 2012

First please see this paper for background info on EGF(R) targeting here.
The aim of this wiki document is to review the characterization of cancerogenic mutations occuring in multiple receptor-associated tyrosine kinase proteins targeting the EGF receptor and perhaps cholesterol based lipid rafts including stearic acid (monosaturated) and in fatty acids derived ligands.

Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
- Epithelial Stem Cells: Turning over New Leaves (Rockefeller University)
Receptor-associated tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes?
- Calmodulin-dependent protein kinase receptors (Ca2+) signal transduction linked to Alzheimer like neuronal dysregulation? (ie: PH based phospholipid dysregulation) ?
Endocannabinoids: Wet Blanket on Hippocampus Excitement
- Hippocampus dysregulation from calcium-dependent lipid-like signaling networks?
  - Etienne Robillard 08:56, 4 May 2012 (EDT): 420 like (CB1 receptors) to the rescue..? :)

Is programmed cell-death from cell-specific DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ?
Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR)
On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of concentrating receptors, the lipids and lipid tethered proteins together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html)
Is the p53 gene dependent on genetical inheritance (DNA-protein interactions) to make epithelial stem cells vulnerable to cancerogenic mutations ?

Src homology domains, SH2, SH3, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy)

@@ Line 12: / Line 12: @@
 ** Calmodulin-dependent protein kinase receptors (Ca2+) signal transduction linked to Alzheimer like neuronal dysregulation? (ie: PH based phospholipid dysregulation) ?
 * [http://www.alzforum.org/new/detail.asp?id=1446 Endocannabinoids: Wet Blanket on Hippocampus Excitement]
-** "'''Hippocampus'''" dysregulation from calcium-dependent '''lipid-like''' signaling networks?
+** '''Hippocampus''' dysregulation from calcium-dependent '''lipid-like''' signaling networks?
 *** [[User:Etienne Robillard|Etienne Robillard]] 08:56, 4 May 2012 (EDT): 420 like (CB1 '''receptors''') to the rescue..? :)