User:Tkadm30/Notebook/EGFR: Difference between revisions
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== | == EGF(R)-mediated drug delivery == | ||
* http://nrresource.org/Pathways/VDR%20Targets/92391.html | * First please see this paper for background info on EGF(R) targeting [http://nrresource.org/Pathways/VDR%20Targets/92391.html here]. | ||
* The aim of this wiki document is to review the characterization of cancerogenic mutations occuring in multiple receptor-associated tyrosine kinase proteins targeting the EGF receptor and perhaps cholesterol based lipid rafts including stearic acid (monosaturated) and polysaccharide fatty acids ligands. | |||
=== Case studies === | === Case studies === | ||
| Line 9: | Line 12: | ||
* '''Receptor-associated''' tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes? | * '''Receptor-associated''' tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes? | ||
== TODO == | |||
* Is programmed cell-death from '''cell-specific''' DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ? | * Is programmed cell-death from '''cell-specific''' DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ? | ||
* Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR) | * Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR) | ||
* On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of '''concentrating receptors, the lipids and lipid tethered proteins''' together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html) | * On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of '''concentrating receptors, the lipids and lipid tethered proteins''' together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html) | ||
** Is the p53 gene dependent on genetical inheritance (DNA-protein interactions) to make epithelial stem cells vulnerable to cancerogenic mutations ? | |||
== Keywords == | |||
Src homology domains, SH2, SH3, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy) | Src homology domains, SH2, SH3, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy) | ||
== References == | |||
<biblio> | <biblio> | ||
* 1998 C. Branden, J. Tooze, "Introduction to protein structure", [270-279] | * 1998 C. Branden, J. Tooze, "Introduction to protein structure", [270-279] | ||
</biblio> | </biblio> | ||
Revision as of 14:54, 3 May 2012
EGF(R)-mediated drug delivery
- First please see this paper for background info on EGF(R) targeting here.
- The aim of this wiki document is to review the characterization of cancerogenic mutations occuring in multiple receptor-associated tyrosine kinase proteins targeting the EGF receptor and perhaps cholesterol based lipid rafts including stearic acid (monosaturated) and polysaccharide fatty acids ligands.
Case studies
- Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
- Epithelial Stem Cells: Turning over New Leaves (Rockefeller University)
- Receptor-associated tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes?
TODO
- Is programmed cell-death from cell-specific DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ?
- Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR)
- On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of concentrating receptors, the lipids and lipid tethered proteins together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html)
- Is the p53 gene dependent on genetical inheritance (DNA-protein interactions) to make epithelial stem cells vulnerable to cancerogenic mutations ?
Keywords
Src homology domains, SH2, SH3, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy)
References
-
C. Branden, J. Tooze, "Introduction to protein structure", [270-279]
