User:Etienne Robillard/Notebook/EGFR

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== Useful links on EGF(R)-mediated drug delivery ==
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== EGF(R)-mediated drug delivery ==
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* http://nrresource.org/Pathways/VDR%20Targets/92391.html
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* First please see this paper for background info on EGF(R) targeting [http://nrresource.org/Pathways/VDR%20Targets/92391.html here].
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* The aim of this wiki document is to review the characterization of cancerogenic mutations occuring in multiple receptor-associated tyrosine kinase proteins targeting the EGF receptor and perhaps cholesterol based lipid rafts including stearic acid (monosaturated) and polysaccharide fatty acids ligands.
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=== Case studies ===
=== Case studies ===
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* '''Receptor-associated''' tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes?
* '''Receptor-associated''' tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes?
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=== TODO ===
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== TODO ==
* Is programmed cell-death from '''cell-specific''' DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ?
* Is programmed cell-death from '''cell-specific''' DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ?
* Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR)
* Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR)
* On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of '''concentrating receptors, the lipids and lipid tethered proteins''' together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html)
* On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of '''concentrating receptors, the lipids and lipid tethered proteins''' together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html)
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** Is the p53 gene dependent on genetical inheritance (DNA-protein interactions) to make epithelial stem cells vulnerable to cancerogenic mutations ?
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=== Keywords ===
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== Keywords ==
Src homology domains, SH2, SH3, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy)
Src homology domains, SH2, SH3, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy)
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=== References ===
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== References ==
<biblio>
<biblio>
* 1998 C. Branden, J. Tooze, "Introduction to protein structure", [270-279]
* 1998 C. Branden, J. Tooze, "Introduction to protein structure", [270-279]
</biblio>
</biblio>

Revision as of 16:54, 3 May 2012

Contents

EGF(R)-mediated drug delivery

  • First please see this paper for background info on EGF(R) targeting here.
  • The aim of this wiki document is to review the characterization of cancerogenic mutations occuring in multiple receptor-associated tyrosine kinase proteins targeting the EGF receptor and perhaps cholesterol based lipid rafts including stearic acid (monosaturated) and polysaccharide fatty acids ligands.


Case studies

  • Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
  • Receptor-associated tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes?

TODO

  • Is programmed cell-death from cell-specific DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ?
  • Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR)
  • On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of concentrating receptors, the lipids and lipid tethered proteins together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html)
    • Is the p53 gene dependent on genetical inheritance (DNA-protein interactions) to make epithelial stem cells vulnerable to cancerogenic mutations ?

Keywords

Src homology domains, SH2, SH3, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy)

References

  1. C. Branden, J. Tooze, "Introduction to protein structure", [270-279] [1998]
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