User:Etienne Robillard/Notebook/EGFR

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* Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
* Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
** [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408375/ Epithelial Stem Cells: Turning over New Leaves] (Rockefeller University)
** [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408375/ Epithelial Stem Cells: Turning over New Leaves] (Rockefeller University)
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* '''Receptor-associated''' tyrosine kinase signaling (SH1/SH2 ?) for targeted drug delivery to epithelial stem cells membranes?
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* '''Receptor-associated''' tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes?
=== TODO ===
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Revision as of 10:12, 3 May 2012

Contents

Useful links on EGF(R)-mediated drug delivery

Case studies

  • Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
  • Receptor-associated tyrosine kinase signaling (SH2/SH3) for targeted drug delivery to epithelial stem cells membranes?

TODO

  • Is programmed cell-death from cell-specific DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ?
  • Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR)
  • On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of concentrating receptors, the lipids and lipid tethered proteins together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html)

Keywords

Src homology domains, SH2, SH3, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy)

References

  1. C. Branden, J. Tooze, "Introduction to protein structure", [270-279] [1998]
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