User:Etienne Robillard/Notebook/EGFR

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(Useful links on EGF(R)-mediated drug delivery)
(Case studies)
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* Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
* Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
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** [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408375/ Epithelial Stem Cells: Turning over New Leaves]
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** [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408375/ Epithelial Stem Cells: Turning over New Leaves] (Rockefeller University)
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* '''Receptor-associated''' tyrosine kinase signaling (SH1/SH2 ?) for targeted drug delivery to epithelial stem cells membranes?
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=== TODO ===
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** Is programmed cell-death from '''cell-specific''' DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ?
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** Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR)
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** On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of '''concentrating receptors, the lipids and lipid tethered proteins''' together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html)
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=== Keywords ===
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Src homology domains, SH1, SH2, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy)
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=== References ===
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<biblio>
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* 1998 C. Branden, J. Tooze, "Introduction to protein structure", [270-279]
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</biblio>

Revision as of 09:20, 3 May 2012

Contents

Useful links on EGF(R)-mediated drug delivery

Case studies

  • Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
  • Receptor-associated tyrosine kinase signaling (SH1/SH2 ?) for targeted drug delivery to epithelial stem cells membranes?

TODO

    • Is programmed cell-death from cell-specific DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ?
    • Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR)
    • On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of concentrating receptors, the lipids and lipid tethered proteins together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html)


Keywords

Src homology domains, SH1, SH2, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy)

References

  1. C. Branden, J. Tooze, "Introduction to protein structure", [270-279] [1998]
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