User:Etienne Robillard/Notebook/Drospirenone

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  • CYP450 mediated [1] (A spironolactone derived alkyloid)
  • optical isomerism (C2) : a HSL (homoserine) lactone derivative ?
  • A high risks of hyperkalemia (K+) was found with long-term use of Yasmin. [2]
  • Ethics of birth control with chiral Schiff base alkyloids in orthogonal Fmoc-carbonyl nucleophilic catalysis? See Grignard reagent .

Yb(OTf)3-catalyzed synthetic pyrrolidines via aldimine-protected analogs (Drosperinone)

  • Hence, is there a Yb(OTf)3 (diastereoselective) route to remote activation of Fmoc-protected alkyloids via MW catalysis of C(2)-symmetric amines, ie Drospirenone ? [3, 4]

References

  1. http://en.wikipedia.org/wiki/Drospirenone
  2. http://en.wikipedia.org/wiki/Spironolactone
  3. Diastereoselective Synthesis of Pyrrolidines via the Yb(OTf)3 Catalyzed Three-Component Reaction of Aldehydes, Amines, and 1,1-Cyclopropanediesters
  4. http://en.wikipedia.org/wiki/Ketoxime
  5. http://en.wikipedia.org/wiki/Aldimine

See also

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