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* DHA exert proneurogenic functions on activated microglia cells. <cite>Paper3</cite> | * DHA exert proneurogenic functions on activated microglia cells. <cite>Paper3</cite> | ||
* heteromeric activation of CB1 receptor by DHA is synaptogenic and neuroprotective to neurons. | * heteromeric activation of CB1 receptor by DHA is synaptogenic and neuroprotective to neurons. | ||
===DHA and vitamin D control of serotonin synthesis=== | |||
* http://www.sciencedaily.com/releases/2015/02/150225094109.htm | |||
=== DHEA (N-docosahexaenoyl ethanolamide) === | === DHEA (N-docosahexaenoyl ethanolamide) === | ||
Revision as of 05:22, 12 January 2016
DHA (docosahexaenoic acid)
Intracellular DHA delivery promote persistent synaptic plasticity and neuroprotection in the hippocampus:
- BDNF-induced synaptogenesis is enhanced by intracellular DHA delivery to neural stem/progenitor cells
- CREB activation may protect neurons from glutamate excitoxicity and neuroinflammation.
DHA increase CREB function by upregulation of mature BDNF (mBDNF) levels:
- mBDNF activate the TrkB receptor and decrease the excitability of GABAergic interneurons. [1]
Neuroprotective properties of DHA:
- DHA is neuroprotective and controlled by the P2X7 purinoreceptor. [2]
- DHA exert proneurogenic functions on activated microglia cells. [3]
- heteromeric activation of CB1 receptor by DHA is synaptogenic and neuroprotective to neurons.
DHA and vitamin D control of serotonin synthesis
DHEA (N-docosahexaenoyl ethanolamide)
- Ethanolamide metabolite of DHA.
- Derivative of anandamide.
- A synaptogenic endocannabinoid with antiglutamatergic and neuroprotective effects that induce synaptogenesis in vivo. [4]
References
- Holm MM, Nieto-Gonzalez JL, Vardya I, Vaegter CB, Nykjaer A, and Jensen K. Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus. J Neurosci. 2009 Oct 7;29(40):12412-8. DOI:10.1523/JNEUROSCI.2978-09.2009 |
Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus.
- Molz S, Olescowicz G, Kraus JR, Ludka FK, and Tasca CI. Purine receptors are required for DHA-mediated neuroprotection against oxygen and glucose deprivation in hippocampal slices. Purinergic Signal. 2015 Mar;11(1):117-26. DOI:10.1007/s11302-014-9438-z |
Purine receptors are required for DHA-mediated neuroprotection against oxygen and glucose deprivation in hippocampal slices.
- Antonietta Ajmone-Cat M, Lavinia Salvatori M, De Simone R, Mancini M, Biagioni S, Bernardo A, Cacci E, and Minghetti L. Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. J Neurosci Res. 2012 Mar;90(3):575-87. DOI:10.1002/jnr.22783 |
Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells.
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Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines.
