User:Tkadm30/Notebook/Cat eye syndrome: Difference between revisions
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=== | === Primer on ADA, CAP, CES, and CAMK2G (KCC2G) : An advanced AHL (light/energy) activated riboswitch and psychochemical agent using orthogonal (synthetic) recombinase promoters === | ||
* EC 3.5.4.4 [http://brenda-enzymes.org/php/result_flat.php4?ecno=3.5.4.4&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 ref] | * EC 3.5.4.4 [http://brenda-enzymes.org/php/result_flat.php4?ecno=3.5.4.4&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 ref] | ||
* also named '''Adenosine deaminase CECR1''' | * also named '''Adenosine deaminase CECR1''' | ||
* Uniprot accession number Q9NZK5 | * Uniprot accession number '''Q9NZK5''' - Check this! Also you may want to verify [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=2231495 rs2231495] for hints about the relevance of auxotrophic genes (alternative splicing) in the phylogenetical evolution of CES. | ||
** See also the [http://www.ncbi.nlm.nih.gov/nuccore/224183182?report=fasta primary reference] (FASTA) for the [http://www.ncbi.nlm.nih.gov/nuccore/NT_011519.10 GRCh37.p10] assembly (genome). | |||
** The latest <font color="red">genome reference</font> for the GRCh37.p11 assembly is available [http://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.23/ here]. | |||
* reaction type -> deamination | * reaction type -> deamination | ||
* tissues: brain, liver, thymus... | * tissues: brain, liver, thymus... | ||
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* related to chromosome 22q11 | * related to chromosome 22q11 | ||
* for PD (Score 8.991) and [[BPA|BPA (bis-phenol-A)]], see also gene [http://www.uniprot.org/uniprot/Q13555 CAMK2G (KCC2G)] - also known as chromosome 22q10. [1] [2] | * for PD (Score 8.991) and [[BPA|BPA (bis-phenol-A)]], see also gene [http://www.uniprot.org/uniprot/Q13555 CAMK2G (KCC2G)] - also known as chromosome 22q10. [1] [2] | ||
=== Positively matching SNPs (clinical data) === | |||
* Oracle: You seem lost. | |||
* Chuck: Keep going... I've seen worst than this. | |||
* Oracle: Fair enough... | |||
* Chuck: Look, I have tons of fb cuties waiting for some action. | |||
* Oracle: Sure. Do you want a little blue cheese with that, sir? | |||
=== Parkinson disease/CES tristable riboswitch device abstraction === | === Parkinson disease/CES tristable riboswitch device abstraction === | ||
* A Parkinson/CES disease "riboswitch" is a AHL-activated ( | * <font color="red">A Parkinson/CES disease "riboswitch" is a AHL-activated (Acyl-Homoserine-Lactone) xenobiotic compound (recombinase system) '''modulating Ca2+/Mg2+ (CAM2KG) specific ions channel to activate RNA polymerase transcription and controlled DNA release of the V. Fischeri specific "LuxR" protein: a functional beta-amyloid ligand regulated by the EnvZ (OmpR) gene.</font> | ||
* See also [http://partsregistry.org/Featured_Parts:Light_Sensor Featured_Parts:Light_Sensor]. [ENVZ, CAMK2G, RIBOSWITCH] | |||
* See also [http://www.youtube.com/watch?v=V6ycmQJOaBQ&feature=endscreen&NR=1 Mind control: An introduction movie to optogenetics from the BBC.] | |||
* See also the relevant Ecocyc.org entry for EnvZ [http://ecocyc.org/ECOLI/NEW-IMAGE?type=GENE&object=EG10269 here]. | |||
* Accession number (E.coli K-12 MG1655 substr): "EG10269". | |||
* Full data available [http://www.uniprot.org/uniprot/P0AEJ4 here]. | |||
* See also the histidine kinase entry (EC 2.7.13.3) [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.7.13.3 here]. | |||
* Get the latest BLAST results for EG10269 [http://www.ecogene.org/prerun/EG10269.html here]. | |||
=== Glossary === | === Glossary === | ||
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* RNA | * RNA | ||
* NMDA | * NMDA | ||
* | * trans-splicing | ||
=== References === | === References === | ||
# http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAMK2G | # http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAMK2G | ||
# http://www.sciencedaily.com/releases/2013/02/130225153122.htm?utm_source=dlvr.it&utm_medium=twitter | # http://www.sciencedaily.com/releases/2013/02/130225153122.htm?utm_source=dlvr.it&utm_medium=twitter |
Revision as of 09:48, 13 March 2013
Primer on ADA, CAP, CES, and CAMK2G (KCC2G) : An advanced AHL (light/energy) activated riboswitch and psychochemical agent using orthogonal (synthetic) recombinase promoters
- EC 3.5.4.4 ref
- also named Adenosine deaminase CECR1
- Uniprot accession number Q9NZK5 - Check this! Also you may want to verify rs2231495 for hints about the relevance of auxotrophic genes (alternative splicing) in the phylogenetical evolution of CES.
- See also the primary reference (FASTA) for the GRCh37.p10 assembly (genome).
- The latest genome reference for the GRCh37.p11 assembly is available here.
- reaction type -> deamination
- tissues: brain, liver, thymus...
- Litterature review: http://www.omim.org/entry/115470
- related to chromosome 22q11
- for PD (Score 8.991) and BPA (bis-phenol-A), see also gene CAMK2G (KCC2G) - also known as chromosome 22q10. [1] [2]
Positively matching SNPs (clinical data)
- Oracle: You seem lost.
- Chuck: Keep going... I've seen worst than this.
- Oracle: Fair enough...
- Chuck: Look, I have tons of fb cuties waiting for some action.
- Oracle: Sure. Do you want a little blue cheese with that, sir?
Parkinson disease/CES tristable riboswitch device abstraction
- A Parkinson/CES disease "riboswitch" is a AHL-activated (Acyl-Homoserine-Lactone) xenobiotic compound (recombinase system) modulating Ca2+/Mg2+ (CAM2KG) specific ions channel to activate RNA polymerase transcription and controlled DNA release of the V. Fischeri specific "LuxR" protein: a functional beta-amyloid ligand regulated by the EnvZ (OmpR) gene.
- See also Featured_Parts:Light_Sensor. [ENVZ, CAMK2G, RIBOSWITCH]
- See also Mind control: An introduction movie to optogenetics from the BBC.
- See also the relevant Ecocyc.org entry for EnvZ here.
- Accession number (E.coli K-12 MG1655 substr): "EG10269".
- Full data available here.
- See also the histidine kinase entry (EC 2.7.13.3) here.
- Get the latest BLAST results for EG10269 here.
Glossary
- ADA
- AHL
- BPA
- CES
- recombinase
- CAMK2G
- Calmodulin
- LuxR
- EnvZ
- PC
- ATP
- LacZ
- PD - Parkinson disease
- cAMP
- riboswitch
- polymerase,
- RNA
- NMDA
- trans-splicing