User:Etienne Robillard/Notebook/Cat eye syndrome

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(GRCh37.p11)
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__TOC__
__TOC__
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=== Introduction to CES ===
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=== Primer on ADA, CAP, CES, and CAMK2G (KCC2G) : An advanced AHL (light/energy) activated riboswitch and psychochemical agent using orthogonal (synthetic) recombinase promoters ===
* EC 3.5.4.4 [http://brenda-enzymes.org/php/result_flat.php4?ecno=3.5.4.4&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 ref]
* EC 3.5.4.4 [http://brenda-enzymes.org/php/result_flat.php4?ecno=3.5.4.4&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 ref]
* also named '''Adenosine deaminase CECR1'''
* also named '''Adenosine deaminase CECR1'''
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* Uniprot accession number Q9NZK5
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* Uniprot accession number '''Q9NZK5''' - Check this! Also you may want to verify [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=2231495 rs2231495] for hints about the relevance of auxotrophic genes (alternative splicing) in the phylogenetical evolution of CES.
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** See also the [http://www.ncbi.nlm.nih.gov/nuccore/224183182?report=fasta primary reference] (FASTA) for the [http://www.ncbi.nlm.nih.gov/nuccore/NT_011519.10 GRCh37.p10] assembly (genome).
 +
** The latest <font color="red">genome reference</font> for the GRCh37.p11 assembly is available [http://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.23/ here].
* reaction type -> deamination
* reaction type -> deamination
* tissues: brain, liver, thymus...
* tissues: brain, liver, thymus...
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* related to chromosome 22q11
* related to chromosome 22q11
* for PD (Score 8.991) and [[BPA|BPA (bis-phenol-A)]], see also gene [http://www.uniprot.org/uniprot/Q13555 CAMK2G (KCC2G)] - also known as chromosome 22q10. [1] [2]
* for PD (Score 8.991) and [[BPA|BPA (bis-phenol-A)]], see also gene [http://www.uniprot.org/uniprot/Q13555 CAMK2G (KCC2G)] - also known as chromosome 22q10. [1] [2]
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 +
=== Positively matching SNPs (clinical data) ===
 +
 +
* Oracle: You seem lost.
 +
* Chuck: Keep going... I've seen worst than this.
 +
* Oracle: Fair enough...
 +
* Chuck: Look, I have tons of fb cuties waiting for some action.
 +
* Oracle: Sure. Do you want a little blue cheese with that, sir?
=== Parkinson disease/CES tristable riboswitch device abstraction ===
=== Parkinson disease/CES tristable riboswitch device abstraction ===
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* A Parkinson/CES disease "riboswitch" is a AHL-activated (acyl-homoserine-lactone) xenobiotic compound (recombinase system) modulating Ca2+/Mg2+ specific ions channel to activate RNA polymerase transcription and controlled DNA release of the  V. Fischeri specific "LuxR" protein: a functional beta-amyloid ligand (NMDA receptor antagonist) regulated by the CAMK2G
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* <font color="red">A Parkinson/CES disease "riboswitch" is a AHL-activated (Acyl-Homoserine-Lactone) xenobiotic compound (recombinase system) '''modulating Ca2+/Mg2+ (CAM2KG) specific ions channel to activate RNA polymerase transcription and controlled DNA release of the  V. Fischeri specific "LuxR" protein: a functional beta-amyloid ligand regulated by the EnvZ (OmpR) gene.</font>
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(calmodulin) gene.
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* See also [http://partsregistry.org/Featured_Parts:Light_Sensor Featured_Parts:Light_Sensor]. [ENVZ, CAMK2G, RIBOSWITCH]
-
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* See also [http://www.youtube.com/watch?v=V6ycmQJOaBQ&feature=endscreen&NR=1 Mind control: An introduction movie to optogenetics from the BBC.]
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* See also the relevant Ecocyc.org entry for EnvZ [http://ecocyc.org/ECOLI/NEW-IMAGE?type=GENE&object=EG10269 here].
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* Accession number (E.coli K-12 MG1655 substr): "EG10269".
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* Full data available [http://www.uniprot.org/uniprot/P0AEJ4 here].
 +
* See also the histidine kinase entry (EC 2.7.13.3) [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.7.13.3 here].
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* Get the latest BLAST results for EG10269 [http://www.ecogene.org/prerun/EG10269.html here].
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=== Glossary ===  
=== Glossary ===  
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* RNA
* RNA
* NMDA
* NMDA
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* etc...
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* trans-splicing
-
 
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=== References ===
=== References ===
# http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAMK2G
# http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAMK2G
# http://www.sciencedaily.com/releases/2013/02/130225153122.htm?utm_source=dlvr.it&utm_medium=twitter
# http://www.sciencedaily.com/releases/2013/02/130225153122.htm?utm_source=dlvr.it&utm_medium=twitter

Revision as of 12:48, 13 March 2013

Contents


Primer on ADA, CAP, CES, and CAMK2G (KCC2G) : An advanced AHL (light/energy) activated riboswitch and psychochemical agent using orthogonal (synthetic) recombinase promoters

  • EC 3.5.4.4 ref
  • also named Adenosine deaminase CECR1
  • Uniprot accession number Q9NZK5 - Check this! Also you may want to verify rs2231495 for hints about the relevance of auxotrophic genes (alternative splicing) in the phylogenetical evolution of CES.
  • reaction type -> deamination
  • tissues: brain, liver, thymus...
  • Litterature review: http://www.omim.org/entry/115470
  • related to chromosome 22q11
  • for PD (Score 8.991) and BPA (bis-phenol-A), see also gene CAMK2G (KCC2G) - also known as chromosome 22q10. [1] [2]

Positively matching SNPs (clinical data)

  • Oracle: You seem lost.
  • Chuck: Keep going... I've seen worst than this.
  • Oracle: Fair enough...
  • Chuck: Look, I have tons of fb cuties waiting for some action.
  • Oracle: Sure. Do you want a little blue cheese with that, sir?

Parkinson disease/CES tristable riboswitch device abstraction

  • A Parkinson/CES disease "riboswitch" is a AHL-activated (Acyl-Homoserine-Lactone) xenobiotic compound (recombinase system) modulating Ca2+/Mg2+ (CAM2KG) specific ions channel to activate RNA polymerase transcription and controlled DNA release of the V. Fischeri specific "LuxR" protein: a functional beta-amyloid ligand regulated by the EnvZ (OmpR) gene.
  • See also Featured_Parts:Light_Sensor. [ENVZ, CAMK2G, RIBOSWITCH]
  • See also Mind control: An introduction movie to optogenetics from the BBC.
  • See also the relevant Ecocyc.org entry for EnvZ here.
  • Accession number (E.coli K-12 MG1655 substr): "EG10269".
  • Full data available here.
  • See also the histidine kinase entry (EC 2.7.13.3) here.
  • Get the latest BLAST results for EG10269 here.

Glossary

  • ADA
  • AHL
  • BPA
  • CES
  • recombinase
  • CAMK2G
  • Calmodulin
  • LuxR
  • EnvZ
  • PC
  • ATP
  • LacZ
  • PD - Parkinson disease
  • cAMP
  • riboswitch
  • polymerase,
  • RNA
  • NMDA
  • trans-splicing

References

  1. http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAMK2G
  2. http://www.sciencedaily.com/releases/2013/02/130225153122.htm?utm_source=dlvr.it&utm_medium=twitter
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