User:Tkadm30/Notebook/Brainstorming

Neurotoxicity of coal fly ash nanoparticles

• Engineered coal fly ash (CFA) nanoparticles are neurotoxic and may contain aluminium oxide, barium, arsenic and dimethyl sulfate.
• Is geoengineering destroying life?
• What are the consequences of being sprayed with barium and aluminium?

Synaptic hypercomputation

• biological utilization of nonlocality and entanglement of water during exocytosis: Is quantum hypercomputation a function of synaptic exocytosis?
• Is quantum interference in brain activity possible?

Phase coherence of synaptic hypercomputation

• Retrograde signaling and synaptogenesis regulate phase coherence of synaptic exocytosis?

Retrograde signaling

• Allosteric modulation of glycine receptors by endocannabinoids
  • THC and anandamide may modulates synaptogenesis in the retina and brain through glycinergic transmission [1]
  • DHA facilitate NMDA receptor activation in the presence of glycine [2]
  • THC and anandamide enhance NMDA-dependent LTP through glycine receptor activation

Cannabinoid-induced cholinergic neurotransmission

• Hypothalamic POMC neurons promote CB1-induced feeding [3]
• Caffeine potentiate striatal neurotransmission through presynaptic CB1 receptor activation. [4]
• Monoamine oxidase inhibition affects cannabinoid-induced synaptogenesis. [5]

intracellular CB1/BDNF signaling

• CB1 receptor activation induce striatal neuroprotection through a PI3K/Akt/mTORC1/BDNF pathway. [6]

Political manipulations of psychiatry (Sluggish schizophrenia)

• Modern psychiatry is a pseudoscience; Its goal is to alienate consciousness based on pseudoscientific voodoo.
  • Schizophrenia is a scam to subvert consciousness with antipsychotics (AP)
• "Psychiatry as a means of intimidation": http://schizophreniabulletin.oxfordjournals.org/content/36/1/33.full
  • Psychiatry is psychological oppression.

Ubiquity of consciousness

• The brain is not the source of consciousness: http://www.tandfonline.com/doi/full/10.1080/19420889.2015.1085138
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245704/
• Intrinsic awareness (IA); A machine has no internal purpose within. http://arxiv.org/abs/1101.2422

References

1. Hejazi N, Zhou C, Oz M, Sun H, Ye JH, and Zhang L. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. Mol Pharmacol. 2006 Mar;69(3):991-7. DOI:10.1124/mol.105.019174 |

   Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors.

2. Nishikawa M, Kimura S, and Akaike N. Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex. J Physiol. 1994 Feb 15;475(1):83-93. DOI:10.1113/jphysiol.1994.sp020051 |

   Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex.

3. Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, and Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature. 2015 Mar 5;519(7541):45-50. DOI:10.1038/nature14260 |

   Hypothalamic POMC neurons promote cannabinoid-induced feeding.

4. Rossi S, De Chiara V, Musella A, Mataluni G, Sacchetti L, Siracusano A, Bernardi G, Usiello A, and Centonze D. Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects. Neuropharmacology. 2009 Mar;56(3):590-7. DOI:10.1016/j.neuropharm.2008.10.013 |

   Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects.

5. Singh C, Bortolato M, Bali N, Godar SC, Scott AL, Chen K, Thompson RF, and Shih JC. Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12816-21. DOI:10.1073/pnas.1308037110 |

   Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.

6. Blázquez C, Chiarlone A, Bellocchio L, Resel E, Pruunsild P, García-Rincón D, Sendtner M, Timmusk T, Lutz B, Galve-Roperh I, and Guzmán M. The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway. Cell Death Differ. 2015 Oct;22(10):1618-29. DOI:10.1038/cdd.2015.11 |

   The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.

7. https://www.jstage.jst.go.jp/article/jts/36/3/36_3_267/_article

   Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats