User:Tkadm30/Notebook/Arylcyclohexylamines/2013/05/24

A jolie passage

• Calcium chloride (CaCl2) != potassium chloride [Ca2+]
• potassium chloride = food additive
• potassium chloride = KCl (anhydrous) [Cl-]
• KCl (-) mediated CREB1 gene expression: ($35.95)
• Keywords: CREB1, NMDA, potassium chloride, CaM kinase, striatal neurons, dizocilpine
• See also: NMDA dependent cell adhesion (aka "calcium binding").

Orthogonal serine/threonine-specific GSK-3 inhibitors

• i found this paper worth the mention (2013): http://www.sciencedirect.com/science/article/pii/S0092867413002857 ($31.50)
• c-fos: http://www.uniprot.org/uniprot/P01100
• CREB2: http://www.genome.jp/dbget-bin/www_bget?hsa:468
• NMDAR1: http://www.kegg.jp/dbget-bin/www_bget?hsa:2902
• You may want to view/download the uniprot datasets here and here.
• Keywords: GSK-3, breast cancer (PKB), Glycine, Wnt signaling pathway
• See also this free PMC article about the GSK-3 kinase here.

Notes

• Désactivation sélective du récepteur NMDAR1 (Ser133?)
  • Note: Ser133 ? (NMDAR1): un récepteur critique à la formation de la protéine beta-amyloid (APP) 4 d'après de récentes études à ce sujet. [2]

References

1. Macías W, Carlson R, Rajadhyaksha A, Barczak A, and Konradi C. Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. Brain Res. 2001 Feb 2;890(2):222-32. DOI:10.1016/s0006-8993(00)03163-2 |

2. Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion

3. De Cesare D, Jacquot S, Hanauer A, and Sassone-Corsi P. Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12202-7. DOI:10.1073/pnas.95.21.12202 |
3. Du K and Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem. 1998 Dec 4;273(49):32377-9. DOI:10.1074/jbc.273.49.32377 |
4. Matthews RP, Guthrie CR, Wailes LM, Zhao X, Means AR, and McKnight GS. Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol Cell Biol. 1994 Sep;14(9):6107-16. DOI:10.1128/mcb.14.9.6107-6116.1994 |
5. Lee HJ, Mignacca RC, and Sakamoto KM. Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133. J Biol Chem. 1995 Jul 7;270(27):15979-83. DOI:10.1074/jbc.270.27.15979 |

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