User:Etienne Robillard/Notebook/Arylcyclohexylamines/2013/05/24

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* potassium chloride = food additive
* potassium chloride = food additive
* potassium chloride = KCl (anhydrous) [Cl-]  
* potassium chloride = KCl (anhydrous) [Cl-]  
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* KCl (-) mediated CREB1 gene expression: http://www.ncbi.nlm.nih.gov/pubmed/11164788 ($35.95)   
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* KCl (-) mediated CREB1 gene expression: ($35.95)   
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** Keywords: [http://www.genome.jp/dbget-bin/www_bget?ko:K05870 CREB1], NMDA, potassium chloride, CaM kinase, striatal neurons, dizocilpine
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* Keywords: [http://www.genome.jp/dbget-bin/www_bget?ko:K05870 CREB1], NMDA, potassium chloride, CaM kinase, striatal neurons, dizocilpine (Ketamine), Serine (phosphorylation), orthogonal phenolic methylamide enolates, active methylenes enolates, metal-bound complexes, -rC=NOH, carbenes (NHC), 4-methylimidazole derivatives (4-Mel, 4-methoxy (4-met), N-benzyl methylamine, pyridineN-methyl acylamino pyridine), [[MEA|Ethanolamine]]
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* See also: [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/NMDA_dependent_cell_adhesion NMDA dependent cell adhesion] (aka the Wnt (Calcium Binding) pathway), Shikimate pathway
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=== NMDAR induced early-onset autistic spectrum (Alzheimer Disease) ===
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=== 4-methylamino carboxilic protection group: Fast and versatile conversion of methylamide esters in presence of a nucleophilic Schiff base (reduktiv) ===
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* i found this paper worth the mention (2013): http://www.openwetware.org/images/a/ac/Li_and_Hanahan.pdf
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# [http://de.wikipedia.org/wiki/Schutzgruppe#Amine PMB]
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* [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/NMDA_dependent_cell_adhesion NMDA dependent cell adhesion (binding) notes]
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# [http://onlinelibrary.wiley.com/doi/10.1002/anie.197805691/ 4-Dialkylaminopyridines as Highly Active Acylation Catalysts. (New synthetic method)]
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=== Orthogonal serine/threonine-specific GSK-3 inhibitors ===
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* i found this paper worth the mention (2013): http://www.sciencedirect.com/science/article/pii/S0092867413002857 ($31.50)
* c-fos: http://www.uniprot.org/uniprot/P01100
* c-fos: http://www.uniprot.org/uniprot/P01100
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* CREB2: http://www.genome.jp/dbget-bin/www_bget?hsa:468
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* NMDAR1: http://www.kegg.jp/dbget-bin/www_bget?hsa:2902
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* You may want to view/download the uniprot datasets [http://www.uniprot.org/uniprot/P16220 here] and [http://www.uniprot.org/uniprot/P31749 here].
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* Keywords: GSK-3, breast cancer (PKB), Glycine, Wnt signaling pathway
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* See also this free PMC article about the GSK-3 kinase [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006448/?report=classic here].
 +
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=== Notes ===
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* Désactivation sélective du récepteur NMDAR1 (Ser133?)
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** Note: Ser133 ? (NMDAR1): un récepteur critique à la formation de la protéine beta-amyloid (APP) 4 d'après de récentes études à ce sujet. [2]
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=== References ===
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<biblio>
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#CREB-2001 pmid=11164788
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#Li-Hanahan-1-2013 [http://dx.doi.org/10.1016/j.cell.2013.02.051 Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion]
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#CREB-1998 pmid=9829964
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#CREB-1998 pmid=9770464
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#CREB-1994 pmid=8065343
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#CREB-1995 pmid=7608156
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</biblio>
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=== Did you know ? ===
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<blockquote>“Whenever the will to power falls off in any way, there will also be physiological decline, decadence. And when the most masculine virtues and drives have been chopped off the god of decadence, he will necessarily turn into a god of the physiologically retrograde, the weak.” – Friedrich Nietzsche - [http://euro-synergies.hautetfort.com/archive/2012/11/22/nietzsche-physiology-transvaluation.html Link]</blockquote>

Revision as of 09:31, 13 July 2013

Contents

A jolie passage

  • Calcium chloride (CaCl2) != potassium chloride [Ca2+]
  • potassium chloride = food additive
  • potassium chloride = KCl (anhydrous) [Cl-]
  • KCl (-) mediated CREB1 gene expression: ($35.95)
  • Keywords: CREB1, NMDA, potassium chloride, CaM kinase, striatal neurons, dizocilpine (Ketamine), Serine (phosphorylation), orthogonal phenolic methylamide enolates, active methylenes enolates, metal-bound complexes, -rC=NOH, carbenes (NHC), 4-methylimidazole derivatives (4-Mel, 4-methoxy (4-met), N-benzyl methylamine, pyridineN-methyl acylamino pyridine), Ethanolamine
  • See also: NMDA dependent cell adhesion (aka the Wnt (Calcium Binding) pathway), Shikimate pathway

4-methylamino carboxilic protection group: Fast and versatile conversion of methylamide esters in presence of a nucleophilic Schiff base (reduktiv)

  1. PMB
  2. 4-Dialkylaminopyridines as Highly Active Acylation Catalysts. (New synthetic method)

Orthogonal serine/threonine-specific GSK-3 inhibitors

Notes

  • Désactivation sélective du récepteur NMDAR1 (Ser133?)
    • Note: Ser133 ? (NMDAR1): un récepteur critique à la formation de la protéine beta-amyloid (APP) 4 d'après de récentes études à ce sujet. [2]


References

  1. Macías W, Carlson R, Rajadhyaksha A, Barczak A, and Konradi C. . pmid:11164788. PubMed HubMed [CREB-2001]
  2. Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion [Li-Hanahan-1-2013]
  3. De Cesare D, Jacquot S, Hanauer A, and Sassone-Corsi P. . pmid:9770464. PubMed HubMed [CREB-1998]
  4. Du K and Montminy M. . pmid:9829964. PubMed HubMed [CREB-1998]
  5. Matthews RP, Guthrie CR, Wailes LM, Zhao X, Means AR, and McKnight GS. . pmid:8065343. PubMed HubMed [CREB-1994]
  6. Lee HJ, Mignacca RC, and Sakamoto KM. . pmid:7608156. PubMed HubMed [CREB-1995]
All Medline abstracts: PubMed HubMed

Did you know ?

“Whenever the will to power falls off in any way, there will also be physiological decline, decadence. And when the most masculine virtues and drives have been chopped off the god of decadence, he will necessarily turn into a god of the physiologically retrograde, the weak.” – Friedrich Nietzsche - Link
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