User:Etienne Robillard/Notebook/Arylcyclohexylamines

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(Arynes, arylacetonitriles, and arylation of 4-trans substituted cyclohexylamine compounds)
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== Introduction ==
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Methylphenidate (trademark Ritalin) HCl is a piperidine derived synthetic drug prescribed in the treatment of schizophrenia and
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autistic disorders to childrens with chronic ADHD (Attention Deficit Hyperactivity Disorder) symptoms.
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The purpose of this document is to investigate the whys and wherefores of Agent Scooby Doo in the product of cyclohexylamine induced reactions
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by comparitive study of psychotropic alkylamines drugs including Methylphenidate and Arylacetonitriles-derived alkylating solvents and their combined effects on
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human NMDA receptor.
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Also the study of PCP derived piperidine analog compounds will be beneficial in the proper understanding of synthetic drug abuses and
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to prevent future disasters by chemical aerosol spraying prohibition and legislation.
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== Psychotropic alkylamines ==
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=== Cyclohexylamines, methamphetamine, and methylphenidate ===
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==== Methylphenidate (Ritalin) ====
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Methylphenidate compound is synthetically comparable to amphetamine-class drug (cocaine), by functioning as a long-term dopamine
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regulator, however its long-term effects on the developmental area of the brain is controversed and poorly understood by
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the scientific community. [[http://en.wikipedia.org/wiki/Methylphenidate#Long-term_effects 1]]
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Moreover, chronic Ritalin use may in addition elevate the risks of amphetamine-induced psychosis, a notable side-effect in
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chronic amphetamine users. Overmedication with amphetamine-type drug is thus an additional concern to assess in the psychotherapy
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of childrens with amphetamine-like drugs.  [[http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html 2]]
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Amphetamine-induced psychosis may implicate as well severe hallucinations and other landmarks of long-term
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drug abuses including altered state of behavior, paranoia, and depression.
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==== N-substituted psychotropic alkylamines derivatives implicated in organic synthesis of orthogonal phosphoramides ====
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* Documentation:
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** http://en.wikipedia.org/wiki/Phase-transfer_catalysis
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** http://en.wikipedia.org/wiki/Amide
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** http://euch6f.chem.emory.edu/arynes.html
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** [http://www.chemguide.co.uk/organicprops/anhydrides/nitrogen.html Reactions of Ketones with Primary Amines]
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** http://research.cm.utexas.edu/nbauld/CHAPTER%2021.htm
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* See also:
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** Aryl ketones (4-trans substituted cyclohexylamines and 4-methoxy derived compounds)
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** 4-hydroxymethyl-1-aryl-cyclohexylamine : US7232847
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** "Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones": http://www.freepatentsonline.com/EP0090262.html
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==== 4,7-dichloroquinoline ====
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* Psychotropic alkylamines induced '''dermatitis''' -> [http://www.sigmaaldrich.com/catalog/product/aldrich/d74002?lang=en&region=SE 4,7-dichloroquinoline]
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** Airborne agents causing reaction with micro wave irradiation? (ie: a wireless connection)
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** An anti-malarial compound? (quinoline)
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** NMDA antagonist?
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** See http://www.ncbi.nlm.nih.gov/pubmed/6213361
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** http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0536.1982.tb04215.x/abstract
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** US Patent Application: 20110281844 ("NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS")
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** http://blogs.ch.cam.ac.uk/pmr/files/2012/12/121712_1039_AMI2Content5.png
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*** see http://blogs.ch.cam.ac.uk
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*** see [http://loinen.i2p.to/rhodium/chemistry/future_drugs.html Future Synthetic Drugs of Abuses]
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== See also ==
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* http://en.wikipedia.org/wiki/Amphetamine
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* http://en.wikipedia.org/wiki/Methamphetamine
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* http://en.wikipedia.org/wiki/Methylphenidate
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* http://en.wikipedia.org/wiki/Methoxetamine
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* http://en.wikipedia.org/wiki/Piperidine
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* http://www.vice.com/read/interview-with-ketamine-chemist-704-v18n2
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* http://learn.genetics.utah.edu/content/addiction/issues/ritalin.html
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* http://www.veteranstoday.com/2012/12/20/sandy-hook-massacre-official-story-spins-out-of-control/
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== Dedication ==
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This page is dedicated to victims of Sandy Hook mass murder which occured on December 14 2012. May our creator give recomfort to the victims of theses uncivilised
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murdering acts and theses tragedies never be forgotten to identify and resolve the problems in our own life which leaded to such horror scenes. -[[User:Etienne Robillard|Etienne Robillard]] 09:50, 20 December 2012 (EST)
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== References ==
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* Reference 1
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* Reference 2
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* US patents :
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** 4-substituted Arylcyclohexylamines derived compounds :
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*** US5622916, US5032616, US4073942, US4113777,US4312861, US3536713, US3336308, US6071966, US5270340, US4595759
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== Glossary ==
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* Ring Systems http://www.chem.qmul.ac.uk/iupac/class/rings.html
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* Nitrogen  http://www.chem.qmul.ac.uk/iupac/class/oneN.html
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[[Category:Chemical]]
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[[Category:Psychochemical]]
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