User:Etienne Robillard/Notebook/Arylcyclohexylamines

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(Side-effects of long-term Benzylamine-based drug delivery over unaware and disinformed Civilian populations)
(Glycine/Serine based alternative NMDA inhibitors)
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=== Microwave activated (R,S)-Methylphenidate (Ritalin) synthesis ===
=== Microwave activated (R,S)-Methylphenidate (Ritalin) synthesis ===
-
[[User:Etienne_Robillard/Notebook/Methylphenidate|Methylphenidate]] (trademark Ritalin) HCl is a [[piperidine|piperidine]] derived synthetic drug prescribed in the treatment of "schizophrenia" and
+
[[User:Etienne_Robillard/Notebook/Methylphenidate|Methylphenidate]] (trademark Ritalin) HCl is a [[User:Etienne_Robillard/Notebook/Piperidine|piperidine]] derived synthetic drug prescribed in the treatment of "schizophrenia" and "bipolar disorders" to childrens with chronic "ADHD" (Attention Deficit Hyperactivity Disorder) symptoms.  
-
"bipolar disorders" to childrens with chronic "ADHD" (Attention Deficit Hyperactivity Disorder) symptoms.  
+
Methylphenidate (MP) compound is synthetically comparable to amphetamine-class drug (cocaine), by functioning as a long-term dopamine
Methylphenidate (MP) compound is synthetically comparable to amphetamine-class drug (cocaine), by functioning as a long-term dopamine
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* Latent peripheral object recognition problems  
* Latent peripheral object recognition problems  
* Amphetamine-induced psychosis (severe-like hallucinations)  
* Amphetamine-induced psychosis (severe-like hallucinations)  
-
* Aggressivity  
+
* Aggressivity (in Male subjects)
-
* unrational thinking  
+
* unrational thinking (in Female subjects)
* chronic dermatitis signs (nb: a apparent sign of microwave-induced burns) [XXX]  
* chronic dermatitis signs (nb: a apparent sign of microwave-induced burns) [XXX]  
* Increased alcoholism  [Benzylamine]
* Increased alcoholism  [Benzylamine]
-
* early-onset Parkinson Disease like symptoms [DS]
+
* <s>early-onset Parkinson Disease like symptoms [DS]</s>
-
* late-onset Alzheimer Disease like symptoms [AD]
+
* early-onset Alzheimer Disease like symptoms [AD]
* Locomotor hyperactivity [Benzylamine]
* Locomotor hyperactivity [Benzylamine]
* S1PR4-induced Breast Cancer [S1PR4]
* S1PR4-induced Breast Cancer [S1PR4]
-
* Anxiety [Note: Althought some people might call this "schizophrenia", not sure why, unless for the medicamentation of anxiety with synthetic drugs, which is fairly odd, given that anxiety is a natural phenomenon humans feel when approaching the unknown, like in no particular order, how the women brain work to legitimate the consent of voluntary slavery, or perhaps synthetic biology, in manufacturing life, love, and empathy, obviously, when the lost of the former become an apparent phenotype, forcing psychiatrists and doctors to dismantle their own oath, in adopting unreasonable and dangerous attitudes, stubbornly labeling peaceful civilians a "schizophreniac", and obeying their apparently inner weaknesses prescribing lethal drugs to civilians who dare to affront the reality of science in all its gory pornographic details, thereby enslaving humans into clouds of electromagnetic waves for their own sicken purposes of wiring humans into addressable semi-conductors to name a few.] -[[User:Etienne_Robillard|ER]] (13.6.9)
+
* Anxiety [Note: Althought some people might call this "schizophrenia", not sure why, unless for the medicamentation of anxiety with synthetic drugs, which is fairly odd, given that anxiety is a natural phenomenon humans feel when approaching the unknown, like in no particular order, how the women brain work to legitimate the consent of voluntary slavery, or perhaps synthetic biology, in manufacturing life, love, and empathy, obviously, when the lost of the former become an apparent phenotype, forcing psychiatrists and doctors to dismantle their own oath, in adopting unreasonable and dangerous attitudes, stubbornly labeling peaceful civilians a "schizophreniac", and obeying their apparently inner weaknesses prescribing lethal drugs to civilians who dare to affront the '''reality of science''' in all its gory pornographic details, thereby enslaving humans into clouds of electromagnetic waves for their own sicken purposes of wiring humans into addressable semi-conductors to name a few.] -[[User:Etienne_Robillard|ER]] (13.6.9)
 +
* Metabolic disorders (Glutamate-specific?) [confirmed? validated?] -[[User:Etienne_Robillard|ER]] (13.7.23)
=== N-substituted psychotropic alkylamines derivatives implicated in organic synthesis of orthogonal phosphoramidates  ===
=== N-substituted psychotropic alkylamines derivatives implicated in organic synthesis of orthogonal phosphoramidates  ===
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** 4-hydroxymethyl-1-aryl-cyclohexylamine : US7232847
** 4-hydroxymethyl-1-aryl-cyclohexylamine : US7232847
* "Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones": http://www.freepatentsonline.com/EP0090262.html
* "Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones": http://www.freepatentsonline.com/EP0090262.html
-
* "phosphines" and the [[Phosphohistidine_transferase|phosphohistidine transferase]] enzyme.
+
* "phosphines" and the [[Phosphohistidine_transferase|phosphohistidine (N-methyl)transferase]] enzyme.
** phosphoramidate based peptide and oligo "coupling" reagents...  
** phosphoramidate based peptide and oligo "coupling" reagents...  
 +
** Imidazole and N-methyl imidazole (1-methylimidazole) : http://en.wikipedia.org/wiki/1-Methylimidazole
* N-substituted cyclohexylaminopyrimidines:
* N-substituted cyclohexylaminopyrimidines:
** E. coli K-12 W3110 (aka the pyrimidine starved strain...)
** E. coli K-12 W3110 (aka the pyrimidine starved strain...)
-
** [http://openwetware.org/wiki/OSDDMalaria:GSK_Amino-thienopyrimidine_Series GSK Amino thienopyrimidine series]
+
** See US5039692 - '''[http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Fmoc_protected_phenoxyalkylamine_synthesis Psychotropic phenoxyalkylamine derivatives and their uses in domestic/civilian experiments with synthetic opioid receptor agonists]''' (1,2-substituted thienopyrimidone)
-
*** See US5039692 - '''[http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Fmoc_protected_phenoxyalkylamine_synthesis Psychotropic phenoxyalkylamine derivatives and their uses in domestic/civilian experiments with synthetic opioid receptor agonists]''' (1,2-substituted thienopyrimidone)
+
*** View also [[Sulfanilamide]] - A compound which has been listed in the Doctor Trials of the Nuremberg nazi medical experiments [http://law2.umkc.edu/faculty/projects/ftrials/nuremberg/NurembergDoctorTrial.html 1]
*** View also [[Sulfanilamide]] - A compound which has been listed in the Doctor Trials of the Nuremberg nazi medical experiments [http://law2.umkc.edu/faculty/projects/ftrials/nuremberg/NurembergDoctorTrial.html 1]
* Keywords:
* Keywords:
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* [[User:Etienne Robillard|Etienne Robillard]] 08:36, 23 January 2013 (EST) How many watts of output can generate a single wireless device (ie Iphone) and is this energy input sufficient to catalyze '''Yb(OTf)3-mediated substrate''' (a Michael acceptor) in a controlled manner, assuming MW-triggered peptide synthesis has faster reactions time than SPPS to deliver anti-malarial drugs?
* [[User:Etienne Robillard|Etienne Robillard]] 08:36, 23 January 2013 (EST) How many watts of output can generate a single wireless device (ie Iphone) and is this energy input sufficient to catalyze '''Yb(OTf)3-mediated substrate''' (a Michael acceptor) in a controlled manner, assuming MW-triggered peptide synthesis has faster reactions time than SPPS to deliver anti-malarial drugs?
-
==== 2-phenoxy-pyrimidine class herbicides ====
+
==== C-(2-phenoxy)-pyrimidine derived alkylamine ====
* benzaldehyde acetals (3 components ketone/amine acetals with aryl moeity.. hell..secondary aldimine mean R3 is not substituted with H atom but with N atom..thus an aryl or alkyl group=R3..)
* benzaldehyde acetals (3 components ketone/amine acetals with aryl moeity.. hell..secondary aldimine mean R3 is not substituted with H atom but with N atom..thus an aryl or alkyl group=R3..)
-
* a type of imine (Schiff base)...
+
* a type of imine [SCHIFF BASE]
-
* [[User:Etienne Robillard|Etienne Robillard]] 15:26, 5 February 2013 (EST): Thus, do you accept the spraying of humans with C(2)-phenoxy alkylamines reagents for the purpose of human genomic experiments, even such experiments were possibly lead by German scientists under the cover of your present or past government? And for what good reason do you assert "Synthetic Biology" is not a genuine indoctrination of your own consciousness, to let you not even  objectify your own dissent agaisn't such human-specific experiments with psychotropic phenoxyalkylamine like alkyloids? . Lastly, do you object agaisn't militarisation of science and development of bioweapons by proceeding in unethical dual-purpose research to engineer virus-like particles (compounds) on the false likelyhood of "saving humanity" from X-Men attacks (ie flumageddon)?
+
 
 +
=== Glycine/Serine based alternative NMDA inhibitors ===
 +
* doi: 10.1124/mol.108.049312
 +
* keywords: glycine, GlyT1, benzamide, oxidative sulfoxide (oxo), piperazine, schizophrenia
 +
* GlyT-1 = alicyclic conformation (chair) at the piperazine ring ?
 +
* 6-membered ring system = cyclohexane, clozapine, olanzapine, imatinib (source is [http://en.wikipedia.org/wiki/Piperazine#Piperazine_derivatives_as_drugs here].)
 +
* 30C6HSL = methylotroph ?
== See also ==
== See also ==
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* Substituted cyclohexylaminopyrimidines derivatives: US5723450, [http://www.google.com/patents/US6197729 US6197729], US6683027
* Substituted cyclohexylaminopyrimidines derivatives: US5723450, [http://www.google.com/patents/US6197729 US6197729], US6683027
* Benzaldehyde acetals and secondary aldimines as auxiliary amine catalysts, C(2)phenoxy-pyrimidine type herbicides (diphenamide):  US5178662, US4985066
* Benzaldehyde acetals and secondary aldimines as auxiliary amine catalysts, C(2)phenoxy-pyrimidine type herbicides (diphenamide):  US5178662, US4985066
 +
* [http://www.faqs.org/patents/app/20090099213 Ortho-Condensed Pyridine and Pyrimidine Derivatives (e.g., Purines) as Protein Kinases Inhibitors] (2009)
== Bibliography ==
== Bibliography ==
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* Aldimine (primary, secondary) : a specific subtype of imine derived from aldehydes, '''where in the primary form, the aniomeric center is an hydroxyl (H) molecule and in the secondary form a alkyl or aryl adduct is formed (aka a [[Schiff_base|Schiff base]]).'''  
* Aldimine (primary, secondary) : a specific subtype of imine derived from aldehydes, '''where in the primary form, the aniomeric center is an hydroxyl (H) molecule and in the secondary form a alkyl or aryl adduct is formed (aka a [[Schiff_base|Schiff base]]).'''  
* Acetal
* Acetal
-
* Aldehyde
+
* [[User:Etienne_Robillard/Notebook/Acetaldehyde|Acetaldehyde]]
 +
** The same thing as a aldehyde, but apparently a branched alcohol specific species. (See "Acetal" above and "Formaldehyde"). Also known as a "ethanal". 
 +
* Aldehyde: See Acetaldehyde
* Benzaldehyde  
* Benzaldehyde  
* Alkyloid : A N-alkyl derived [[carbene]] (NHC) or non-specific DNA alkylating agent. See also [[Imidazole]] and [[NH2]].  
* Alkyloid : A N-alkyl derived [[carbene]] (NHC) or non-specific DNA alkylating agent. See also [[Imidazole]] and [[NH2]].  
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* Imine: The '''tautomeric form''' (functional group) of chiral enatiomers with one C=N double bond.  
* Imine: The '''tautomeric form''' (functional group) of chiral enatiomers with one C=N double bond.  
* Isonitrile: The same thing as Carbylamine
* Isonitrile: The same thing as Carbylamine
 +
* Formaldehyde:
* FRET: Fluorescence Resonance Energy Transfer
* FRET: Fluorescence Resonance Energy Transfer
* Ketone: See http://www2.chemistry.msu.edu/faculty/reusch/virttxtjml/aldket1.htm
* Ketone: See http://www2.chemistry.msu.edu/faculty/reusch/virttxtjml/aldket1.htm

Revision as of 09:55, 8 November 2013

Contents


Introduction

The purpose of this notebook is to investigate the whys and wherefores of Agent Scooby Doo in the product of N-benzylamine induced reactions by comparitive study of psychotropic alkylamines drugs including Methylphenidate' and Arylacetonitriles-derived alkylating solvents and their combined effects on human NMDA receptor and also GABA.

Psychotropic, optically-activated methylenes enolates (Amphetamine group)

Microwave activated (R,S)-Methylphenidate (Ritalin) synthesis

Methylphenidate (trademark Ritalin) HCl is a piperidine derived synthetic drug prescribed in the treatment of "schizophrenia" and "bipolar disorders" to childrens with chronic "ADHD" (Attention Deficit Hyperactivity Disorder) symptoms.

Methylphenidate (MP) compound is synthetically comparable to amphetamine-class drug (cocaine), by functioning as a long-term dopamine regulator, however its long-term effects on the developmental area of the brain is controversed and poorly understood by the scientific community. [1]

Moreover, chronic Ritalin use may in addition elevate the risks of amphetamine-induced psychosis, a notable side-effect in chronic amphetamine users. Overmedication with amphetamine-type drug is thus an additional concern to assess in the psychotherapy of childrens with amphetamine-like drugs. [2]

Side-effects of long-term Benzylamine-based drug delivery over unaware and disinformed Civilian populations

  • Latent peripheral object recognition problems
  • Amphetamine-induced psychosis (severe-like hallucinations)
  • Aggressivity (in Male subjects)
  • unrational thinking (in Female subjects)
  • chronic dermatitis signs (nb: a apparent sign of microwave-induced burns) [XXX]
  • Increased alcoholism [Benzylamine]
  • early-onset Parkinson Disease like symptoms [DS]
  • early-onset Alzheimer Disease like symptoms [AD]
  • Locomotor hyperactivity [Benzylamine]
  • S1PR4-induced Breast Cancer [S1PR4]
  • Anxiety [Note: Althought some people might call this "schizophrenia", not sure why, unless for the medicamentation of anxiety with synthetic drugs, which is fairly odd, given that anxiety is a natural phenomenon humans feel when approaching the unknown, like in no particular order, how the women brain work to legitimate the consent of voluntary slavery, or perhaps synthetic biology, in manufacturing life, love, and empathy, obviously, when the lost of the former become an apparent phenotype, forcing psychiatrists and doctors to dismantle their own oath, in adopting unreasonable and dangerous attitudes, stubbornly labeling peaceful civilians a "schizophreniac", and obeying their apparently inner weaknesses prescribing lethal drugs to civilians who dare to affront the reality of science in all its gory pornographic details, thereby enslaving humans into clouds of electromagnetic waves for their own sicken purposes of wiring humans into addressable semi-conductors to name a few.] -ER (13.6.9)
  • Metabolic disorders (Glutamate-specific?) [confirmed? validated?] -ER (13.7.23)

N-substituted psychotropic alkylamines derivatives implicated in organic synthesis of orthogonal phosphoramidates

Student resources:

Arylcyclohexylamines and N-substituted cyclohexylaminopyrimidines derivatives

1,2,3,4-tetrahydroisoquinolines (N-substituted benzoxazole) derivatives

4,7-dichloroquinoline

Taking the Yb(OTf)3 road to Sandy Hook

  • Etienne Robillard 11:18, 19 January 2013 (EST) Also interesting, microwave-triggered disubstituted oxadiazoles derivatives for psychotropic alkylamine catalysis using Yb(OTf)3.
  • Etienne Robillard 08:17, 21 January 2013 (EST) In addition, single P-N enantiomers (enamide) can be fused into aromatic heterocycle ring systems in a reaction known as asymmetric hydrogenation. See also Carboxamide, a sulfonamide like carbonic anhydrase inhibitor to block in humans the catalysis of carbonic acid from infectious parasites like P. falciparum, a parasitic worm, thus preventing further cellular respiration to occur. [Related: 1, Malaria, Mefloquine, Carbonic anhydrase] [doi:10.1016/S221-1691(11)60034-8]
  • Etienne Robillard 11:07, 22 January 2013 (EST) Hence, did neuroscience student James Holmes took anti-malarial drug before opening fire in Sandy Hook theater and commiting mass murder of Afghanistan childrens?
    • Etienne Robillard 11:07, 22 January 2013 (EST) In my understanding, the evidences for microwave-triggered (MW) peptide synthesis may provide to crime-scene investigators (CSI) additional evidences to confirm the role of Yb(OTf)3 as an important factor (organocatalyst) in gold-mediated nanoparticles drug delivery, thus a poorly-documented portrait of synthetic biology may emerge in the understanding of common denominators corroborated from theses cases of recent gun shooting into civilian, gun-free zones (schools, theaters, malls, etc).
  • Etienne Robillard 08:36, 23 January 2013 (EST) How many watts of output can generate a single wireless device (ie Iphone) and is this energy input sufficient to catalyze Yb(OTf)3-mediated substrate (a Michael acceptor) in a controlled manner, assuming MW-triggered peptide synthesis has faster reactions time than SPPS to deliver anti-malarial drugs?

C-(2-phenoxy)-pyrimidine derived alkylamine

  • benzaldehyde acetals (3 components ketone/amine acetals with aryl moeity.. hell..secondary aldimine mean R3 is not substituted with H atom but with N atom..thus an aryl or alkyl group=R3..)
  • a type of imine [SCHIFF BASE]

Glycine/Serine based alternative NMDA inhibitors

  • doi: 10.1124/mol.108.049312
  • keywords: glycine, GlyT1, benzamide, oxidative sulfoxide (oxo), piperazine, schizophrenia
  • GlyT-1 = alicyclic conformation (chair) at the piperazine ring ?
  • 6-membered ring system = cyclohexane, clozapine, olanzapine, imatinib (source is here.)
  • 30C6HSL = methylotroph ?

See also

Dedication

This page is dedicated to victims of Sandy Hook mass murder which occured on December 14 2012. May our creator give recomfort to the victims of theses uncivilised murdering acts and theses tragedies never be forgotten to identify and resolve the problems in our own life which leaded to such horror scenes. -Etienne Robillard 09:50, 20 December 2012 (EST)

References

  • Reference 1
  • Reference 2
  • 4-(trans)-N-substituted arylcyclohexylamines derived compounds : US7977370, US5622916, US5032616, US4073942, US4113777,US4312861, US3536713, US3336308, US6071966, US5270340, US4595759
  • Substituted cyclohexylaminopyrimidines derivatives: US5723450, US6197729, US6683027
  • Benzaldehyde acetals and secondary aldimines as auxiliary amine catalysts, C(2)phenoxy-pyrimidine type herbicides (diphenamide): US5178662, US4985066
  • Ortho-Condensed Pyridine and Pyrimidine Derivatives (e.g., Purines) as Protein Kinases Inhibitors (2009)

Bibliography

  1. Rueping M and Nachtsheim BJ. . pmid:20485588. PubMed HubMed [Rueping-Boris-J-Nachtsheim-Beilstein-J-Org-Chem-2010]

Glossary

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