User:Etienne Robillard/Notebook/30C6HSL/2013/03/18

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
(Calmodulin kinase type II Beta subunit protein acquisition and expression with 30C6HSL based exogenous promoters (E. coli K12))
(Clinical significance of exogenous promoters (30C6HSL) in the morphogenesis of Breast cancer, CES, Parkinson, and Alzheimer diseases via site-directed signaling (mutagenesis))
(4 intermediate revisions not shown.)
Line 1: Line 1:
== Long-term effects of imidazole-induced calcium channel blockers (b-amyloids) on neuronal growth: Dude wheres my axon? ==  
== Long-term effects of imidazole-induced calcium channel blockers (b-amyloids) on neuronal growth: Dude wheres my axon? ==  
 +
 +
<blockquote>"''I submit that an individual who breaks a law that conscience tells him is unjust, and who willingly accepts the penalty of imprisonment in order to arouse the conscience of  the community over its injustice, is in reality expressing the highest respect for the law.''"
 +
- Martin Luther King Jr</blockquote>
__TOC__
__TOC__
Line 16: Line 19:
*** http://www.ncbi.nlm.nih.gov/nuccore/D11105 - Link to FASTA sequence file is [http://www.ncbi.nlm.nih.gov/nuccore/216585?report=fasta here].
*** http://www.ncbi.nlm.nih.gov/nuccore/D11105 - Link to FASTA sequence file is [http://www.ncbi.nlm.nih.gov/nuccore/216585?report=fasta here].
* 2007 - ''Reversible acyl-homoserine lactone binding to purified Vibrio fischeri LuxR protein.'' http://www.ncbi.nlm.nih.gov/pubmed/14729687?dopt=Abstract and [[http://www.openwetware.org/wiki/IGEM:IMPERIAL/2007 1]]
* 2007 - ''Reversible acyl-homoserine lactone binding to purified Vibrio fischeri LuxR protein.'' http://www.ncbi.nlm.nih.gov/pubmed/14729687?dopt=Abstract and [[http://www.openwetware.org/wiki/IGEM:IMPERIAL/2007 1]]
-
** ''Recovering patients often suffer <font color="red">hallucinations, and sometimes become psychotic</font>'' : http://www.openwetware.org/wiki/Image:IGEM2007_Imperial_iGEMGlobe.png
+
** <u><font color=purple>''"Recovering patients often suffer hallucinations, and sometimes become psychotic</font>"''</u> : http://www.openwetware.org/wiki/Image:IGEM2007_Imperial_iGEMGlobe.png
* 2008 -  
* 2008 -  
* 2009 -
* 2009 -
-
* 2010 - (current?), '''Unknown phenotype'''.  Homo sapiens (GRCh37.p10), s288c (Baker Yeast), E.coli BL21(DES3), E. coli, E. coli K12 (MG1655), W3110  : ''Berkeley Lab scientists open electrical link to living cells'' : http://www.eurekalert.org/pub_releases/2010-10/dbnl-bls102010.php
+
* 2010 - '''Unknown phenotype'''.  Homo sapiens (GRCh37.p10), s288c (Baker Yeast), E.coli BL21(DES3), E. coli, E. coli K12 (MG1655), W3110  : ''Berkeley Lab scientists open electrical link to living cells'' : http://www.eurekalert.org/pub_releases/2010-10/dbnl-bls102010.php
 +
* 2013 - <font color=magenta>"''5 Disorders Share Genetic Risk Factors, Study Finds''"</font>: http://www.nytimes.com/2013/03/01/health/study-finds-genetic-risk-factors-shared-by-5-psychiatric-disorders.html
=== Calmodulin kinase type II Beta subunit protein acquisition and expression with 30C6HSL based exogenous promoters (E. coli K12) ===
=== Calmodulin kinase type II Beta subunit protein acquisition and expression with 30C6HSL based exogenous promoters (E. coli K12) ===
Line 30: Line 34:
* Browse the annotations for the Yeast (CMK1) ligand [http://www.uniprot.org/uniprot/P27466 here]. (EC 2.7.11.17)
* Browse the annotations for the Yeast (CMK1) ligand [http://www.uniprot.org/uniprot/P27466 here]. (EC 2.7.11.17)
-
=== Clinical significance of exogenous promoters (30C6HSL) in the morphogenesis of Breast cancer, CES, Parkinson, and Alzheimer diseases via site-directed signaling (mutagenesis) ===
+
=== Clinical significance of exogenous promoters (30C6HSL) in the morphogenesis of Breast cancer (erbb2), CES, Parkinson, and Alzheimer diseases via site-directed signaling (mutagenesis) ===
* Brain disorders : patient become mentally ill/unstable (<font color=red>psychotic</font>) and unable to express clear/rational thoughs  
* Brain disorders : patient become mentally ill/unstable (<font color=red>psychotic</font>) and unable to express clear/rational thoughs  
* Visual hallucinations (see Brain disorders above)
* Visual hallucinations (see Brain disorders above)

Revision as of 09:22, 28 April 2013

Long-term effects of imidazole-induced calcium channel blockers (b-amyloids) on neuronal growth: Dude wheres my axon?

"I submit that an individual who breaks a law that conscience tells him is unjust, and who willingly accepts the penalty of imprisonment in order to arouse the conscience of the community over its injustice, is in reality expressing the highest respect for the law." - Martin Luther King Jr

Contents


Introduction to CAMK2B protein overexpression

  • examine the acquisition and mutation of the CAMK2B gene in humans subject to horizontal 30C6HSL based transcription promoters (or "devices" for eugenic doctors).
  • Calmodulin dependent inverse/split-pericams and CAMK2B interactions: CAMK2B may depend on exogenous promoters to convey the drug at the right time/place (site-directed mutagenesis). Notice that CAMK2B overexpression is probably an indicator of low neuronal activity (inverse pericams) or osmolitic regulator. (Critical sites: brain (frontal cortex region), amygdala and perhaps the hippocampus, a critical site for memory related brain functions.)
  • Never forget atmospheric NH2 as natural source of Nitrogen, hence a ethyl-methyl carbanion may be conjugated to a NH2 molecule in a process known as "benzoin condensation" to produce crystals (N-substituted benzoxazole heterocyclics), thus a form of artificial (asymmetric) Schiff base synthesis may occur as the result of injection of psychochemical intermediates into the atmosphere.

A synthetic biology approach to light-activated protein delivery : A review of recent advancements in synthetic mind control

Calmodulin kinase type II Beta subunit protein acquisition and expression with 30C6HSL based exogenous promoters (E. coli K12)

  • GO:1901896 positive regulation of calcium-transporting ATPase activity: http://www.ebi.ac.uk/QuickGO/GTerm?id=GO:1901896
  • GO:0005513 detection of calcium ion: http://www.ebi.ac.uk/QuickGO/GTerm?id=GO:0005513
  • GO:0006970 (osmY) : http://www.ebi.ac.uk/QuickGO/GTerm?id=GO:0006970
    • Co-occuring terms/annotations for "osmY" are found here.
  • Significance of CAMK2B gene acquisition and amplification with exogenous 30C6HSL promoters : Within the rigid “β -can” structure (6) of GFP variants, Baird et al. (7) found a site that would tolerate circular permutations where two portions of the polypeptide are flipped around the central site. With obvious clefts in the β-can, the chromophore of the circularly permuted GFPs (cpGFP) seemed to be more accessible to protons outside of the proteins. The use of cpGFP might be interesting for converting the interaction signal between two protein domains into a change in the electrostatic potential of the chromophore; in other words, to transduce the information of the interaction into a fluorescent signal. [1]
    • Important Note: THIS IS NOT THE SAME NAGAI et al... The other one has DOI: 10.1038/73767. -ER
  • Browse the annotations for the Yeast (CMK1) ligand here. (EC 2.7.11.17)

Clinical significance of exogenous promoters (30C6HSL) in the morphogenesis of Breast cancer (erbb2), CES, Parkinson, and Alzheimer diseases via site-directed signaling (mutagenesis)

  • Brain disorders : patient become mentally ill/unstable (psychotic) and unable to express clear/rational thoughs
  • Visual hallucinations (see Brain disorders above)
  • intellect skills degradation (ie the difficulty to learn, remember or acquire new learnings..)
  • agressivity (esp. in male subjects)
  • selective mutism (esp. in female subjects)
Personal tools