User:Tkadm30/Notebook/Endocannabinoids/2-AG: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
Line 9: Line 9:
===Notes===
===Notes===


* Neuroprotective (anti-inflammatory) and a potent cytoprotective agent (antioxidant)
Astrocytes-induced synaptogenesis is enhanced by synaptic retrograde signaling. Thus homeostatic plasticity is increased by endogenous cannabinoid mobilization.
* retrograde 2-AG signaling modulate glutamatergic LTP/DSE [https://www.ncbi.nlm.nih.gov/pubmed/23307660 PMID]
 
* Anxiolytic
* ionotropic (permeable to calcium) P2X7 receptor control 2-AG production [https://www.ncbi.nlm.nih.gov/pubmed/14976257 PMID]
* calcium dependent biosynthesis
* ATP-induced 2-AG production from astrocytes [https://www.ncbi.nlm.nih.gov/pubmed/15371507 PMID] [https://www.ncbi.nlm.nih.gov/pubmed/17207662 PMID]
** 2-AG activate endogenous phospholipase C-dependent TRPV1 channel in the brain.
** doi:10.1038/srep04329
===Results===
===Results===
2-AG exert neuroprotective effects on excitotoxic brain injury.  
2-AG exert neuroprotective effects on excitotoxic brain injury.  
===See also===
===See also===
* [[User:Etienne_Robillard/Notebook/Phospholipase_C|Phospholipase C Notebook]]
* [[User:Etienne_Robillard/Notebook/Phospholipase_C|Phospholipase C Notebook]]

Revision as of 07:24, 8 October 2015

2-arachidonoylglycerol (2-AG)

Synopsis

A novel gliotransmitter controlled by the P2X7 receptor;

2-AG is an endogenous cannabinoid ligand synthesized by diacylglycerol lipase (DGL-α) and phospholipase C (PLC).

Notes

Astrocytes-induced synaptogenesis is enhanced by synaptic retrograde signaling. Thus homeostatic plasticity is increased by endogenous cannabinoid mobilization.

Results

2-AG exert neuroprotective effects on excitotoxic brain injury.

See also

Retrieved from "https://openwetware.org/mediawiki/index.php?title=User:Tkadm30/Notebook/Endocannabinoids/2-AG&oldid=906964"