User:Despaux: Difference between revisions
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My research concerns nucleic acids as adaptive gene regulatory elements in mammalian cells. These molecules are able to detect changes in the cellular environment, e.g. cancerous or infected, and act accordingly. I'm currently designing and testing RNA molecules to efficiently knock down genes in cancerous cells but not in normal cells. Previously I've worked on human genetic evolution, drug delivery, tissue engineering, novel nucleic acids, and macromolecular transport across nuclear pores. | My research concerns nucleic acids as adaptive gene regulatory elements in mammalian cells. These molecules are able to detect changes in the cellular environment, e.g. cancerous or infected, and act accordingly. I'm currently designing and testing RNA molecules to efficiently knock down genes in cancerous cells but not in normal cells. Previously I've worked on human genetic evolution, drug delivery, tissue engineering, novel nucleic acids, and macromolecular transport across nuclear pores. | ||
Department of Chemical Engineering, California Institute of Technology, 9/2005–present</ | Department of Chemical Engineering, California Institute of Technology, 9/2005–present<br/> | ||
Advisor: Christina Smolke</ | Advisor: Christina Smolke<br/> | ||
Ligand-dependent control of gene expression through non-coding RNA | Ligand-dependent control of gene expression through non-coding RNA | ||
Howard Hughes Medical Institute, The Rockefeller University, 6/2005–9/ | Howard Hughes Medical Institute, The Rockefeller University, 6/2005–9/<br/> | ||
Advisor: [Günter Blobel]</ | Advisor: [Günter Blobel]<br/> | ||
Purification and characterization of nuclear membrane complex proteins | Purification and characterization of nuclear membrane complex proteins | ||
Department of Biological Engineering, Cornell University, 1/2002–5/2005</ | Department of Biological Engineering, Cornell University, 1/2002–5/2005<br/> | ||
Advisor: Dan Luo</ | Advisor: Dan Luo <br/> | ||
Synthesis and design of DNA-based, self-assembled nanoscale structures | Synthesis and design of DNA-based, self-assembled nanoscale structures | ||
School of Chemical Engineering, Cornell University, 9/2001 – 5/2002</ | School of Chemical Engineering, Cornell University, 9/2001 – 5/2002<br/> | ||
Advisor: W. Mark Saltzman</ | Advisor: W. Mark Saltzman<br/> | ||
Tissue engineering and polymer-based drug delivery | Tissue engineering and polymer-based drug delivery | ||
Department of Biology, Florida International University, 6/2000 | Department of Biology, Florida International University, 6/2000–11/2000<br/> | ||
Advisor: René Herrera</ | Advisor: René Herrera<br/> | ||
Human genetic evolution | Human genetic evolution | ||
==Publications== | ==Publications== | ||
# “Controlled assembly of dendrimer like DNA”, Y. Li, Y.D. Tseng, S.Y. Kwon, L. d'Espaux, J.S. Bunch, P.L McEuen, and D. Luo, ''Nature Materials'' '''3''', 38-42, (January, 2004) [http://www.its.caltech.edu/~despaux/papers/Luo-naturematerials2004.pdf] | # “Controlled assembly of dendrimer like DNA”, Y. Li, Y.D. Tseng, S.Y. Kwon, L. d'Espaux, J.S. Bunch, P.L McEuen, and D. Luo, ''Nature Materials'' '''3''', 38-42, (January, 2004) [http://www.its.caltech.edu/~despaux/papers/Luo-naturematerials2004.pdf] | ||
# “Honeycomb-shaped DNA”, L. d’Espaux, and D. Luo, ''Proceedings of the 18th Annual Cornell Undergraduate Research Board Forum'', 69 (March, 2002) | # “Honeycomb-shaped DNA”, L. d’Espaux, and D. Luo, ''Proceedings of the 18th Annual Cornell Undergraduate Research Board Forum'', 69 (March, 2002) | ||
Revision as of 19:11, 31 July 2006
Leo d'Espaux
Graduate Student
Chemical Engineering, MC 210-41
California Institute of Technology
Pasadena, CA 91125-4100
t. 626.395.2753
f. 626.568.8743
despaux@caltech.edu
Education
Ph.D. Student, Chemical Engineering, Caltech , 2005-present
B.S., Chemical Engineering, Cornell , 2005
Honors and Awards
Graduate Research Fellowship, National Science Foundation, 2006-present
Betty and Gordon Moore Fellowship, California Institute of Technology, 2005-present
Menschel Public Service Fellowship, Cornell University, 2005
Slayton Evans Research Award, American Chemical Society, 2003
Alumni Sponsored Research Award, Cornell University, 2003
Presidential Research Scholar, Cornell University, 2001-2005
ACS-Xerox Scholar, American Chemical Society, 2001-2005
Gates Millenium Scholar, Bill and Melinda Gates Foundation, 2001-2006
Research
My research concerns nucleic acids as adaptive gene regulatory elements in mammalian cells. These molecules are able to detect changes in the cellular environment, e.g. cancerous or infected, and act accordingly. I'm currently designing and testing RNA molecules to efficiently knock down genes in cancerous cells but not in normal cells. Previously I've worked on human genetic evolution, drug delivery, tissue engineering, novel nucleic acids, and macromolecular transport across nuclear pores.
Department of Chemical Engineering, California Institute of Technology, 9/2005–present
Advisor: Christina Smolke
Ligand-dependent control of gene expression through non-coding RNA
Howard Hughes Medical Institute, The Rockefeller University, 6/2005–9/
Advisor: [Günter Blobel]
Purification and characterization of nuclear membrane complex proteins
Department of Biological Engineering, Cornell University, 1/2002–5/2005
Advisor: Dan Luo
Synthesis and design of DNA-based, self-assembled nanoscale structures
School of Chemical Engineering, Cornell University, 9/2001 – 5/2002
Advisor: W. Mark Saltzman
Tissue engineering and polymer-based drug delivery
Department of Biology, Florida International University, 6/2000–11/2000
Advisor: René Herrera
Human genetic evolution
Publications
- “Controlled assembly of dendrimer like DNA”, Y. Li, Y.D. Tseng, S.Y. Kwon, L. d'Espaux, J.S. Bunch, P.L McEuen, and D. Luo, Nature Materials 3, 38-42, (January, 2004) [1]
- “Honeycomb-shaped DNA”, L. d’Espaux, and D. Luo, Proceedings of the 18th Annual Cornell Undergraduate Research Board Forum, 69 (March, 2002)
