User:Despaux: Difference between revisions

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==Leo d'Espaux==
==Leo d'Espaux==
Graduate Student<br/>
[[image:Mug.png]]<br/>
Smolke Lab<br/>
Postdoctoral Research Fellow<br/>
Stanford Bioengineering
Keasling Lab<br/>
Joint BioEnergy Institute<br/>
Lawrence Berkeley National Lab


==Education==
==Education==
Ph.D. Candidate, Chemical Engineering, [http://www.caltech.edu Caltech]
Ph.D., Chemical Engineering, [http://www.caltech.edu Caltech]
, 2007-present <br/>
, 2013 <br/>
M.S., Chemical Engineering, [http://www.caltech.edu Caltech]
M.S., Chemical Engineering, [http://www.caltech.edu Caltech]
, 2007<br/>
, 2007<br/>
B.S., Chemical Engineering, [http://www.cornell.edu Cornell]
B.S., Chemical Engineering, [http://www.cornell.edu Cornell]
, 2005
, 2005<br/>
[http://openwetware.org/images/4/42/CV_Leo_dEspaux.pdf CV]


==Research==
==Research==
My research concerns using engineered RNA as adaptive gene regulatory elements. These RNAs are able to detect changes in the cellular environment, e.g., cancerous or benign, and act in response to that information, e.g., lead the cell to kill itself or do nothing. I'm currently designing and testing RNA molecules to efficiently knock down genes in cancerous cells but not in normal cells. In addition, I'm extending existing RNA regulatory platforms to be responsive to new signals, or to respond to signals with improved dynamics. <br/>
My research concerns synthetic regulation of eukaryotic gene expression for applications in green production of chemicals and gene therapy.
 
[https://docs.google.com/document/d/1lJhW32h3W_EvAz3vnvh-rYihmdGZN4aBWQqSoX-RLII/edit?usp=sharing Protocols]


==Publications==
==Publications==


# “Controlled assembly of dendrimer like DNA”, Y. Li, Y.D. Tseng, S.Y. Kwon, L. d'Espaux, J.S. Bunch, P.L McEuen, and D. Luo, ''Nature Materials'' '''3''', 38-42, (January, 2004). doi:10.1038/nmat1045 pmid:14704783. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14704783 PubMed]  [http://www.its.caltech.edu/~despaux/papers/Luo-naturematerials2004.pdf]
#'''L d’Espaux''', YH Wang, and CD Smolke. 2014. A modular genetic amplifier for digital control over eukaryotic gene expression. In preparation.
# “Honeycomb-shaped DNA”, L. d’Espaux, and D. Luo, ''Proceedings of the 18th Annual Cornell Undergraduate Research Board Forum'', 69 (March, 2002)
#AB Kennedy*, JV Vowles*, '''L d’Espaux''', and CD Smolke. 2014. Protein-responsive ribozyme switches in eukaryotic cells. Nucleic Acids Research [http://nar.oxfordjournals.org/content/early/2014/10/01/nar.gku875.abstract| link]
#Y Li, YD Tseng, SY Kwon, '''L d’Espaux''', JS Bunch, PL McEuen and D Luo. 2004. Controlled assembly of dendrimer-like DNA. Nature Materials [http://www.nature.com/nmat/journal/v3/n1/full/nmat1045.html| link]


==Miscellaneous==
==Miscellaneous==

Latest revision as of 17:56, 14 November 2014

Leo d'Espaux


Postdoctoral Research Fellow
Keasling Lab
Joint BioEnergy Institute
Lawrence Berkeley National Lab

Education

Ph.D., Chemical Engineering, Caltech , 2013
M.S., Chemical Engineering, Caltech , 2007
B.S., Chemical Engineering, Cornell , 2005
CV

Research

My research concerns synthetic regulation of eukaryotic gene expression for applications in green production of chemicals and gene therapy.

Protocols

Publications

  1. L d’Espaux, YH Wang, and CD Smolke. 2014. A modular genetic amplifier for digital control over eukaryotic gene expression. In preparation.
  2. AB Kennedy*, JV Vowles*, L d’Espaux, and CD Smolke. 2014. Protein-responsive ribozyme switches in eukaryotic cells. Nucleic Acids Research link
  3. Y Li, YD Tseng, SY Kwon, L d’Espaux, JS Bunch, PL McEuen and D Luo. 2004. Controlled assembly of dendrimer-like DNA. Nature Materials link

Miscellaneous

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