User:Despaux: Difference between revisions

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==Leo d'Espaux==
==Leo d'Espaux==
Graduate Student<br/>
[[image:Mug.png]]<br/>
Chemical Engineering, MC 210-41<br/>
Postdoctoral Research Fellow<br/>
California Institute of Technology<br/>
Keasling Lab<br/>
Pasadena, CA 91125-4100<br/>
Joint BioEnergy Institute<br/>
t.  626.395.2753<br/>
Lawrence Berkeley National Lab
f.  626.568.8743<br/>
despaux@caltech.edu


==Education==
==Education==
Ph.D. Student, Chemical Engineering, [http://www.caltech.edu Caltech]
Ph.D., Chemical Engineering, [http://www.caltech.edu Caltech]
, 2005-present
, 2013 <br/>
 
M.S., Chemical Engineering, [http://www.caltech.edu Caltech]
, 2007<br/>
B.S., Chemical Engineering, [http://www.cornell.edu Cornell]
B.S., Chemical Engineering, [http://www.cornell.edu Cornell]
, 2005
, 2005<br/>
 
[http://openwetware.org/images/4/42/CV_Leo_dEspaux.pdf CV]
==Honors and Awards==
Graduate Research Fellowship, National Science Foundation, 2006-present<br/>
Betty and Gordon Moore Fellowship, California Institute of Technology, 2005-present <br/>
Menschel Public Service Fellowship, Cornell University, 2005<br/>
Slayton Evans Research Award, American Chemical Society, 2003<br/>
Alumni Sponsored Research Award, Cornell University, 2003<br/>
Presidential Research Scholar, Cornell University, 2001-2005<br/>
ACS-Xerox Scholar, American Chemical Society, 2001-2005<br/>
Gates Millenium Scholar, Bill and Melinda Gates Foundation, 2001-2006


==Research==
==Research==
My research concerns nucleic acids as adaptive gene regulatory elements in mammalian cells. These molecules are able to detect changes in the cellular environment, e.g. cancerous or infected, and act accordingly. I'm currently designing and testing RNA molecules to efficiently knock down genes in cancerous cells but not in normal cells. Previously I've worked on human genetic evolution, drug delivery, tissue engineering, novel nucleic acids, and macromolecular transport across nuclear pores.
My research concerns synthetic regulation of eukaryotic gene expression for applications in green production of chemicals and gene therapy.


Department of Chemical Engineering, California Institute of Technology, 9/2005–present</br>
[https://docs.google.com/document/d/1lJhW32h3W_EvAz3vnvh-rYihmdGZN4aBWQqSoX-RLII/edit?usp=sharing Protocols]
Advisor: Christina Smolke</br>
Ligand-dependent control of gene expression through non-coding RNA


Howard Hughes Medical Institute, The Rockefeller University, 6/2005–9/2005</br>
==Publications==
Advisor: [Günter Blobel]</br>
Purification and characterization of nuclear membrane complex proteins


Department of Biological Engineering, Cornell University, 1/2002–5/2005</br>
#'''L d’Espaux''', YH Wang, and CD Smolke. 2014. A modular genetic amplifier for digital control over eukaryotic gene expression. In preparation.
Advisor: Dan Luo</br>
#AB Kennedy*, JV Vowles*, '''L d’Espaux''', and CD Smolke. 2014. Protein-responsive ribozyme switches in eukaryotic cells. Nucleic Acids Research [http://nar.oxfordjournals.org/content/early/2014/10/01/nar.gku875.abstract| link]
Synthesis and design of DNA-based, self-assembled nanoscale structures
#Y Li, YD Tseng, SY Kwon, '''L d’Espaux''', JS Bunch, PL McEuen and D Luo. 2004. Controlled assembly of dendrimer-like DNA. Nature Materials [http://www.nature.com/nmat/journal/v3/n1/full/nmat1045.html| link]


School of Chemical Engineering, Cornell University, 9/2001 – 5/2002</br>
==Miscellaneous==
Advisor: W. Mark Saltzman</br>
<html>
Tissue engineering and polymer-based drug delivery
<a href="http://clustrmaps.com/counter/maps.php?url=http://openwetware.org/wiki/User:Despaux" id="clustrMapsLink"><img src="http://clustrmaps.com/counter/index2.php?url=http://openwetware.org/wiki/User:Despaux" border=1 alt="Locations of visitors to this page"onError="this.onError=null; this.src='http://www.meetomatic.com/images/clustrmaps-back-soon.jpg'; document.getElementById('clustrMapsLink').href='http://clustrmaps.com/'">
 
</a>
Department of Biology, Florida International University, 6/2000 – 11/2000
</html>
Advisor: René Herrera</br>
Human genetic evolution
==Publications==
# “Controlled assembly of dendrimer like DNA”, Y. Li, Y.D. Tseng, S.Y. Kwon, L. d'Espaux, J.S. Bunch, P.L McEuen, and D. Luo, ''Nature Materials'' '''3''', 38-42, (January, 2004) [http://www.its.caltech.edu/~despaux/papers/Luo-naturematerials2004.pdf]
# “Honeycomb-shaped DNA”,  L. d’Espaux, and D. Luo, ''Proceedings of the 18th Annual Cornell Undergraduate Research Board Forum'', 69 (March, 2002)

Latest revision as of 17:56, 14 November 2014

Leo d'Espaux


Postdoctoral Research Fellow
Keasling Lab
Joint BioEnergy Institute
Lawrence Berkeley National Lab

Education

Ph.D., Chemical Engineering, Caltech , 2013
M.S., Chemical Engineering, Caltech , 2007
B.S., Chemical Engineering, Cornell , 2005
CV

Research

My research concerns synthetic regulation of eukaryotic gene expression for applications in green production of chemicals and gene therapy.

Protocols

Publications

  1. L d’Espaux, YH Wang, and CD Smolke. 2014. A modular genetic amplifier for digital control over eukaryotic gene expression. In preparation.
  2. AB Kennedy*, JV Vowles*, L d’Espaux, and CD Smolke. 2014. Protein-responsive ribozyme switches in eukaryotic cells. Nucleic Acids Research link
  3. Y Li, YD Tseng, SY Kwon, L d’Espaux, JS Bunch, PL McEuen and D Luo. 2004. Controlled assembly of dendrimer-like DNA. Nature Materials link

Miscellaneous

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