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==Leo d'Espaux==
==Leo d'Espaux==
Graduate Student<br/>
[[image:Mug.png]]<br/>
[http://openwetware.org/wiki/Smolke Smolke Lab]<br/>
Postdoctoral Research Fellow<br/>
Chemical Engineering, MC 210-41<br/>
Joint BioEnergy Institute<br/>
California Institute of Technology<br/>
Lawrence Berkeley National Lab
Pasadena, CA 91125-4100<br/>
t.  626.395.2753<br/>
f.  626.568.8743<br/>
despaux@caltech.edu


==Education==
==Education==
Ph.D. Student, Chemical Engineering, [http://www.caltech.edu Caltech]
Ph.D., Chemical Engineering, [http://www.caltech.edu Caltech]
, 2005-present
, 2013 <br/>
 
M.S., Chemical Engineering, [http://www.caltech.edu Caltech]
, 2007<br/>
B.S., Chemical Engineering, [http://www.cornell.edu Cornell]
B.S., Chemical Engineering, [http://www.cornell.edu Cornell]
, 2005
, 2005<br/>
 
[http://openwetware.org/images/4/42/CV_Leo_dEspaux.pdf CV]
==Honors and Awards==
Graduate Research Fellowship, National Science Foundation, 2006-present<br/>
Betty and Gordon Moore Fellowship, California Institute of Technology, 2005-present <br/>
Menschel Public Service Fellowship, Cornell University, 2005<br/>
Slayton Evans Research Award, American Chemical Society, 2003<br/>
Alumni Sponsored Research Award, Cornell University, 2003<br/>
Presidential Research Scholar, Cornell University, 2001-2005<br/>
ACS-Xerox Scholar, American Chemical Society, 2001-2005<br/>
Gates Millenium Scholar, Bill and Melinda Gates Foundation, 2001-2006


==Research==
==Research==
My research concerns nucleic acids as adaptive gene regulatory elements in mammalian cells. These molecules are able to detect changes in the cellular environment, e.g. cancerous or infected, and act accordingly. I'm currently designing and testing RNA molecules to efficiently knock down genes in cancerous cells but not in normal cells. Previously I've worked on human genetic evolution, drug delivery, tissue engineering, novel nucleic acids, and macromolecular transport across nuclear pores.
My research concerns synthetic regulation of eukaryotic gene expression for applications in green production of chemicals and gene therapy.


==Publications==
==Publications==


# “Controlled assembly of dendrimer like DNA”, Y. Li, Y.D. Tseng, S.Y. Kwon, L. d'Espaux, J.S. Bunch, P.L McEuen, and D. Luo, ''Nature Materials'' '''3''', 38-42, (January, 2004). doi:10.1038/nmat1045 pmid:14704783. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14704783 PubMed]  [http://www.its.caltech.edu/~despaux/papers/Luo-naturematerials2004.pdf]
#'''LD d’Espaux''', YH Wang, and CD Smolke. 2013. A modular genetic amplifier for near-digital control over eukaryotic gene expression. In preparation.
# “Honeycomb-shaped DNA”, L. d’Espaux, and D. Luo, ''Proceedings of the 18th Annual Cornell Undergraduate Research Board Forum'', 69 (March, 2002)
#'''LD d’Espaux''', AB Kennedy, JV Vowles, and CD Smolke. 2013. Synthetic protein-responsive ribozyme switches in eukaryotic cells. In preparation.
 
#Y Li, YD Tseng, SY Kwon, '''LD d’Espaux''', JS Bunch, PL McEuen and D Luo. 2004. Controlled assembly of dendrimer-like DNA. Nature Materials 3, 38-42.
==Protocols==
Here is a list of protocols I have compiled. Please send me an email with any comments or suggestions. I'll put these somewhere more accessible later.
 
 
[http://www.its.caltech.edu/~despaux/protocols/Ba001_Plasmid%20DNA%20Recovery.doc Plasmid prep with alkaline lysis]
 
[http://www.its.caltech.edu/~despaux/protocols/Ba002_Electroporation.doc Electroporation]
 
[http://www.its.caltech.edu/~despaux/protocols/En001_Polymerase%20Chain%20Reaction.doc PCR]
 
[http://www.its.caltech.edu/~despaux/protocols/En002_digestion.doc Restriction endonuclease digestion]
 
[http://www.its.caltech.edu/~despaux/protocols/En003_Ligation.doc Ligation with T4 Ligase]
 
[http://www.its.caltech.edu/~despaux/protocols/En004_Klenow%20Polymerization.doc Klenow polymerization]
 


==Miscellaneous==
==Miscellaneous==
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Revision as of 17:06, 19 November 2013

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Leo d'Espaux


Postdoctoral Research Fellow
Joint BioEnergy Institute
Lawrence Berkeley National Lab

Education

Ph.D., Chemical Engineering, Caltech , 2013
M.S., Chemical Engineering, Caltech , 2007
B.S., Chemical Engineering, Cornell , 2005
CV

Research

My research concerns synthetic regulation of eukaryotic gene expression for applications in green production of chemicals and gene therapy.

Publications

  1. LD d’Espaux, YH Wang, and CD Smolke. 2013. A modular genetic amplifier for near-digital control over eukaryotic gene expression. In preparation.
  2. LD d’Espaux, AB Kennedy, JV Vowles, and CD Smolke. 2013. Synthetic protein-responsive ribozyme switches in eukaryotic cells. In preparation.
  3. Y Li, YD Tseng, SY Kwon, LD d’Espaux, JS Bunch, PL McEuen and D Luo. 2004. Controlled assembly of dendrimer-like DNA. Nature Materials 3, 38-42.

Miscellaneous

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