User:Andor J Kiss

Contact Info

• Visiting Assistant Professor
• Department of Zoology
• 194 Pearson Hall
• Miami University
• Oxford, OH 45056

• Email me through OpenWetWare

I work in collaboration with the Laboratory for Ecophysiological Cryobiology and am a member of the Center for Visual Sciences at Miami University.

Education

• 2005, PhD, University of Illinois at Urbana-Champaign
• 1999, MSc, University of Western Ontario
• 1994, BSc, University of Victoria

Research interests

1. Adaptive and evolutionary physiology of vertebrate animals. More specifically I am interested in their adaptation to extreme cold and heat, and how their physiological systems have evolved to allow them to exploit such niches. The model system that I have been using is that of the proteins in the eye lens. The proteins are called “crystallins” and play an important role in light refraction. Most vertebrates (excluding some birds) have three kinds of crystallins; alpha (α), beta (β) and gamma (γ). Alpha crystallin is also a type of small heat shock (sHSP) protein and comes in at least two flavours (isoforms). One of these α isoforms can be found widely expressed outside the eye lens and has important roles as a stress protein in a number of tissues. The β and γ crystallins are part of the same super-gene family, but presently there are no known non-refractive structure/function roles. Adaptation of ectothermic vertebrate lenses to cold is of interest to me as means of modeling not only lens cataracts, but to modeling globular protein stability. Lens cataract is a rare example of a system that allows investigation into stability of globular non-enzymatic proteins and protein systems.

1. Interest 2
2. Interest 3

Publications

1. Kiss,A.J. and Cheng,C-H.C. (2008). Molecular diversity and genomic organisation of the α, β and γ eye lens crystallins from the Antarctic toothfish Dissostichus mawsoni doi:10.1016/j.cbd.2008.02.002

2. Kiss AJ, Mirarefi AY, Ramakrishnan S, Zukoski CF, Devries AL, and Cheng CH. Cold-stable eye lens crystallins of the Antarctic nototheniid toothfish Dissostichus mawsoni Norman. J Exp Biol. 2004 Dec;207(Pt 26):4633-49. DOI:10.1242/jeb.01312 |

   The above paper was an Editorial feature entitled Blindingly Cold in the Journal of Experimental Biology

3. Kiss A, Farah K, Kim J, Garriock RJ, Drysdale TA, and Hammond JR. Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain. Biochem J. 2000 Dec 1;352 Pt 2(Pt 2):363-72.
4. Hunt JG, Kasinsky HE, Elsey RM, Wright CL, Rice P, Bell JE, Sharp DJ, Kiss AJ, Hunt DF, Arnott DP, Russ MM, Shabanowitz J, and Ausió J. Protamines of reptiles. J Biol Chem. 1996 Sep 20;271(38):23547-57. DOI:10.1074/jbc.271.38.23547 |
5. ISBN:9780123741691

   Chapter Contribution: The Antarctic Toothfish: A new model system for eye lens biology.

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