User:Allison K. Alix/Notebook/CHEM-581/2013/02/08 - Revision history

Allison K. Alix at 20:33, 8 February 2013

Allison K. Alix — Fri, 08 Feb 2013 20:33:02 GMT

←Older revision		Revision as of 20:33, 8 February 2013
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	{\|{{table}} width="800"		{\|{{table}} width="800"
	\|-		\|-
-	\|style="background-color: #EEE"\|[[Image:BDLlogo_notext_lr.png\|128px]]<span style="font-size:22px;"> ~~Experimental Chemistry~~</span>	+	\|style="background-color: #EEE"\|[[Image:BDLlogo_notext_lr.png\|128px]]<span style="font-size:22px;"> Swelling/Stomach Acid Studies</span>
	\|style="background-color: #F2F2F2" align="center"\|<html><img src="/images/9/94/Report.png" border="0" /></html> [[{{#sub:{{FULLPAGENAME}}\|0\|-11}}\|Main project page]]<br />{{#if:{{#lnpreventry:{{FULLPAGENAME}}}}\|<html><img src="/images/c/c3/Resultset_previous.png" border="0" /></html>[[{{#lnpreventry:{{FULLPAGENAME}}}}{{!}}Previous entry]]<html>      </html>}}{{#if:{{#lnnextentry:{{FULLPAGENAME}}}}\|[[{{#lnnextentry:{{FULLPAGENAME}}}}{{!}}Next entry]]<html><img src="/images/5/5c/Resultset_next.png" border="0" /></html>}}		\|style="background-color: #F2F2F2" align="center"\|<html><img src="/images/9/94/Report.png" border="0" /></html> [[{{#sub:{{FULLPAGENAME}}\|0\|-11}}\|Main project page]]<br />{{#if:{{#lnpreventry:{{FULLPAGENAME}}}}\|<html><img src="/images/c/c3/Resultset_previous.png" border="0" /></html>[[{{#lnpreventry:{{FULLPAGENAME}}}}{{!}}Previous entry]]<html>      </html>}}{{#if:{{#lnnextentry:{{FULLPAGENAME}}}}\|[[{{#lnnextentry:{{FULLPAGENAME}}}}{{!}}Next entry]]<html><img src="/images/5/5c/Resultset_next.png" border="0" /></html>}}
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Allison K. Alix — Fri, 08 Feb 2013 20:31:56 GMT

Observations

←Older revision		Revision as of 20:31, 8 February 2013
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	==Observations==		==Observations==

-	-22,000 g/mol PVOH prepared on [[User:Allison_K._Alix/Notebook/CHEM-581/2013/01/30\|1/30/2013]] did not form a hydrogel. After three freeze thaw cycles (24 hours @ -20°C, 24 hours at room temperature) the sample was still very much a liquid. This being said, we have concluded this molecular weight is not suitable for our drug delivery system.	+	-22,000 g/mol PVOH prepared on [[User:Allison_K._Alix/Notebook/CHEM-581/2013/01/30\|1/30/2013]] did not form a hydrogel. After three freeze thaw cycles (24 hours @ -20°C, 24 hours at room temperature) the sample was still very much a liquid. This being said, we have concluded that this molecular weight is not suitable for our drug delivery system.

-	-nanospheres that were prepared on Wednesday may be too small for our system. We are looking to alter the procedure slightly so we can make spheres ~~slight~~ bigger (micro or even milli scale)	+	-The nanospheres that were prepared on Wednesday may be too small for our system. We are looking to alter the procedure slightly so we can make spheres slighty bigger (micro or even milli scale)

	[[Category:Course]]		[[Category:Course]]

Allison K. Alix — Fri, 08 Feb 2013 20:31:19 GMT

Observations

←Older revision		Revision as of 20:31, 8 February 2013
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	==Observations==		==Observations==

-	-22,000 g/mol PVOH did not form a hydrogel. After three freeze thaw cycles (24 hours @ -20°C, 24 hours at room temperature) the sample was still very much a liquid. This being said, we have concluded this molecular weight is not suitable for our drug delivery system.	+	-22,000 g/mol PVOH prepared on [[User:Allison_K._Alix/Notebook/CHEM-581/2013/01/30\|1/30/2013]] did not form a hydrogel. After three freeze thaw cycles (24 hours @ -20°C, 24 hours at room temperature) the sample was still very much a liquid. This being said, we have concluded this molecular weight is not suitable for our drug delivery system.

	-nanospheres that were prepared on Wednesday may be too small for our system. We are looking to alter the procedure slightly so we can make spheres slight bigger (micro or even milli scale)		-nanospheres that were prepared on Wednesday may be too small for our system. We are looking to alter the procedure slightly so we can make spheres slight bigger (micro or even milli scale)

Allison K. Alix — Fri, 08 Feb 2013 20:23:49 GMT

Objective

←Older revision		Revision as of 20:23, 8 February 2013
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	- Mimic Stomach Acid environment to verify that hydrogel core will dissolve without liposome shell		- Mimic Stomach Acid environment to verify that hydrogel core will dissolve without liposome shell

-	- Swelling Study of pure hydrogels in water	+	- Swelling Study of pure hydrogels in water (how much water will each hydrogel hold? this will help us understand how much insulin we can place in each pill so that all of it is able to be absorbed into the blood.)

	==Procedures==		==Procedures==

Allison K. Alix — Fri, 08 Feb 2013 20:22:12 GMT

Data

←Older revision		Revision as of 20:22, 8 February 2013
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-	'''Photos of hydrogels (MW= 22,000g/mol, 89,000 g/mol, 130,000 g/mol respectively)'''	+	'''Photos of hydrogels (MW= 22,000g/mol, 89,000 g/mol, 130,000 g/mol, and 146,000 g/mol respectively)'''

	[[Image:2013-02-08 12.18.19.jpg\|center\|400px\|]]		[[Image:2013-02-08 12.18.19.jpg\|center\|400px\|]]
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	[[Image:2013-02-08 12.21.31.jpg\|center\|400px\|]]		[[Image:2013-02-08 12.21.31.jpg\|center\|400px\|]]
		+
		+
		+	[[Image:2013-02-08_12.25.11.jpg\|center\|400px\|]]

	==Observations==		==Observations==

Allison K. Alix — Fri, 08 Feb 2013 20:20:26 GMT

Data

←Older revision		Revision as of 20:20, 8 February 2013
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	==Data==		==Data==

-	Photos of hydrogels (MW= 22,000g/mol, 89,000 g/mol, 130,000 g/mol respectively)	+	'''Masses of hydrogels used for stomach acid/water swelling studies'''
		+
		+	''146,000 g/mol''
		+
		+	{\| class="wikitable" style="float: left;" border="1";"
		+	! scope="col" \| pH
		+	! scope="col" \| mass (g)
		+	\|-
		+	\| 1.5 \|\| 0.18
		+	\|-
		+	\| 2.5 \|\| 0.16
		+	\|-
		+	\| 3.5 \|\| 0.18
		+	\|-
		+	\| water \|\| 0.22
		+	\|}
		+
		+
		+
		+
		+
		+
		+
		+
		+
		+
		+	130,000 g/mol
		+
		+	{\| class="wikitable" style="float: left;" border="1";"
		+	! scope="col" \| pH
		+	! scope="col" \| mass (g)
		+	\|-
		+	\| 1.5 \|\| 0.54
		+	\|-
		+	\| 2.5 \|\| 0.56
		+	\|-
		+	\| 3.5 \|\| 0.43
		+	\|-
		+	\| water \|\| 0.66
		+	\|}
		+
		+
		+
		+
		+
		+
		+
		+
		+
		+
		+	89,000 g/mol
		+
		+	{\| class="wikitable" style="float: left;" border="1";"
		+	! scope="col" \| pH
		+	! scope="col" \| mass (g)
		+	\|-
		+	\| 1.5 \|\| 0.58
		+	\|-
		+	\| 2.5 \|\| 0.59
		+	\|-
		+	\| 3.5 \|\| 0.60
		+	\|-
		+	\| water \|\| 0.55
		+	\|}
		+
		+
		+
		+
		+
		+
		+
		+
		+
		+
		+
		+	'''Photos of hydrogels (MW= 22,000g/mol, 89,000 g/mol, 130,000 g/mol respectively)'''

	[[Image:2013-02-08 12.18.19.jpg\|center\|400px\|]]		[[Image:2013-02-08 12.18.19.jpg\|center\|400px\|]]

Allison K. Alix — Fri, 08 Feb 2013 20:09:32 GMT

Data

←Older revision		Revision as of 20:09, 8 February 2013
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	==Data==		==Data==
		+
		+	Photos of hydrogels (MW= 22,000g/mol, 89,000 g/mol, 130,000 g/mol respectively)

	[[Image:2013-02-08 12.18.19.jpg\|center\|400px\|]]		[[Image:2013-02-08 12.18.19.jpg\|center\|400px\|]]

Allison K. Alix — Fri, 08 Feb 2013 20:07:27 GMT

Data

Allison K. Alix — Fri, 08 Feb 2013 20:04:57 GMT

Data

Allison K. Alix — Fri, 08 Feb 2013 19:57:27 GMT

Data