User:Allison K. Alix/Notebook/CHEM-581/2013/01/30

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Objective

Begin hydrogel formation using freeze-thaw method for the design of a system that allows for the oral delivery of insulin.

Description

Currently the oral delivery of insulin is not possible, due to it's degradation in the stomach before reaching the bloodstream. This project will employ a hydrogel core (to begin synthesis today) which will ultimately be coated by a lipid bilayer.

Procedure

Dissolve 0.5g PVOH of the following molecular weights in 6mL of H2O @ 95°C :

a) 22,000 (MP Biomedicals)

b) 89,000-98,000 99+% hydrolysis(Aldrich Chemistry)

c) 130,000 99+% hydrolysis(Aldrich Chemistry)

d) 146,000-186,000 99+% hydrolysis(Aldrich Chemistry)


-Make 2 samples of each different Molecular Weight.

Data

  • Add data and results here...

References

http://jtc.sagepub.com/content/early/2011/12/26/0892705711430857.full.pdf+html http://www.kirj.ee/public/proceedings_pdf/2009/issue_1/proc-2009-1-63-66.pdf



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