User:Ahmad A. Mannan: Difference between revisions

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==About Me==
='''BIOMATHS JOURNAL CLUB'''=


* '''Ahmad A. Mannan''' ''MSci ARCS PhD''
We put together a journal club for sharing and discussing papers and problems (theory) of mathematical modelling of biological systems (both stochastically and deterministically).
* ''Research Associate in Systems and Synthetic Biology of Metabolic Adaptations.''
 
== NEXT GATHERING ==
[[Image:Screen Shot 2015-10-06 at 21.46.45.png|thumb|none|upright=2|Example of an image I uploaded and embedded into my Wiki.]]
[[Image:Screen Shot 2015-10-06 at 21.46.45.png|thumb|none|upright=2|Example of an image I uploaded and embedded into my Wiki.]]


==Contact Information==
* Date: '''THURSDAY 11TH FEBRUARY'''
* Time: ''3-4PM''
* Venue: '''HUXLEY 747'''
 
* Paper: [http://genome.cshlp.org/content/early/2015/09/09/gr.191635.115.abstract '''Noise in Gene Expression is Coupled to Growth Rate''']
 
 
== COMPILATION OF PAPERS TO READ ==
 
* Division in Escherichia coli is triggered by a size-sensing rather than a timing mechanism[http://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-12-17]
 
* Slow Protein Fluctuations Explain the Emergence of Growth Phenotypes and Persistence in Clonal Bacterial Populations [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054272]
 
* Stress‐response balance drives the evolution of a network module and its host genome [http://msb.embopress.org/content/11/8/827]


* Department of Mathematics, Imperial College London, London, SW7 2AZ
* Emergent genetic oscillations in a synthetic microbial consortium [http://www.sciencemag.org/content/349/6251/986]
* ResearchGate Profile [https://www.researchgate.net/profile/Ahmad_Mannan Link].
 
* [[Special:Emailuser/Ahmad A. Mannan|Email me through OpenWetWare]]
* Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms [http://www.nature.com/nrg/journal/v16/n8/full/nrg3922.html?WT.ec_id=NRG-201508&spMailingID=49120140&spUserID=MjQyMjM5ODg1ODIS1&spJobID=722171134&spReportId=NzIyMTcxMTM0S0]
 
* A noisy linear map underlies oscillations in cell size and gene expression in bacteria [http://www.nature.com/nature/journal/v523/n7560/full/nature14562.html]
 
* Replication of DNA in bacteria with heterogeneous generation times [http://www.sciencedirect.com/science/article/pii/0022519368901689]
 
* Duplication of the bacterial cell and its initiation [http://www.sciencedirect.com/science/article/pii/S0022519369800214]
 
* Dilution of the cell cycle inhibitor Whi5 controls budding-yeast cell size [http://www.nature.com/nature/journal/v526/n7572/full/nature14908.html]
 
* A growth‐rate composition formula for the growth of E. coli on co‐utilized carbon substrates [http://msb.embopress.org/content/11/4/801?cpetoc]
 
* Macromolecular Crowding as a Regulator of Gene Transcription [http://ac.els-cdn.com/S0006349514002252/1-s2.0-S0006349514002252-main.pdf?_tid=b9ed6474-f5b7-11e4-94fc-00000aacb362&acdnat=1431113197_efa850dca9a5b6af11f5934d25ea6ad8]
 
* Cell Size and the Initiation of DNA Replication in Bacteria [http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002549]
 
* How fast-growing bacteria robustly tune their ribosome concentration to approximate growth-rate maximisation [http://www.ncbi.nlm.nih.gov/pubmed/25754869]
 
* Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations [http://www.nature.com/nature/journal/v513/n7518/full/nature13469.html?WT.ec_id=NATURE-20140918]
 
* Does evolutionary theory need a rethink? [http://www.nature.com/news/does-evolutionary-theory-need-a-rethink-1.16080]
 
* A cross-chiral RNA polymerase ribozyme [http://www.nature.com/nature/journal/v515/n7527/full/nature13900.html?WT.ec_id=NATURE-20141120]
 
* Cell cycle: It takes three to find the exit [http://www.nature.com/nature/journal/v517/n7532/full/nature14080.html]
 
* Loss of growth homeostasis by genetic decoupling of cell division from biomass growth: implication for size control mechanisms [http://msb.embopress.org/content/10/12/769?cpetoc]
 
* Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation [http://msb.embopress.org/content/10/12/770?cpetoc]
 
* Cell dynamics and gene expression control in tissue homeostasis and development [http://msb.embopress.org/content/11/2/792?cpetoc]
 
* Quantitative evolutionary dynamics using high-resolution lineage tracking [http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14279.html?WT.ec_id=NATURE-20150226], with comment [http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14207.html?WT.ec_id=NATURE-20150226 HERE]
 
* Conditional density-based analysis of T cell signaling in single-cell data [http://www.sciencemag.org/content/346/6213/1250689.full.pdf?keytype=ref&siteid=sci&ijkey=Ng%2FJai9AuY2kc]
 
* Evolution of context dependent regulation by expansion of feast/famine regulatory proteins [http://www.biomedcentral.com/1752-0509/8/122]
 
* Carbon source-dependent expansion of the genetic code in bacteria [http://www.ncbi.nlm.nih.gov/pubmed/23185002]


I am a research associate in Systems and Synthetic Biology and am very interested in biological sciences and mathematical modelling.
* Reducing the genetic code induces massive rearrangement of the proteome [http://www.ncbi.nlm.nih.gov/pubmed/25404328]
I found the paper <cite>Soma2014</cite> fascinating.


==Education==
* Conserved codon composition of ribosomal protein coding genes inEscherichia coli, Mycobacterium tuberculosis and Saccharomyces cerevisiae: lessons from supervised machine learning in functional genomics [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117187/]
<!--Include info about your educational background-->
* 2008-2012 - PhD Systems Biology, University of Surrey
* 2003-2007 - MSci Mathematics, Imperial College London


==Research Interests==
== CONTACT INFORMATION ==
<!-- Feel free to add brief descriptions to your research interests as well -->
# Systems Biology
# Synthetic Biology
# Mathematical Modelling of Dynamical Systems


<span style="color:red;">Visit the home page of our Lab from [[Mannan|THIS]] link.</span>
Please feel free to e-mail me if you would like to suggest another paper to discuss at the group:
* [[Special:Emailuser/Ahmad A. Mannan|Email me through OpenWetWare]]
* <span style="color:red;">Visit the home page of our Lab from [http://www.imperial.ac.uk/people/d.oyarzun THIS] link.</span>


==Important Data==
An excel file uploaded into Wiki, containing some example experimental data, can be found at the following link: [[Image:TestData.xlsx]]


==Publications==
==Publications==
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications.  You can add or remove lines as needed -->
<!-- Replace the PubMed ID's ("pmid=#######") below with the PubMed ID's for your publications.  You can add or remove lines as needed -->
<biblio>
<biblio>
#Soma2014 pmid=24576819
// Really interesting paper!
#Klipp2009 isbn=9783527318742
#Klipp2009 isbn=9783527318742
</biblio>
</biblio>

Revision as of 10:23, 5 February 2016

BIOMATHS JOURNAL CLUB

We put together a journal club for sharing and discussing papers and problems (theory) of mathematical modelling of biological systems (both stochastically and deterministically).

NEXT GATHERING

Example of an image I uploaded and embedded into my Wiki.
  • Date: THURSDAY 11TH FEBRUARY
  • Time: 3-4PM
  • Venue: HUXLEY 747


COMPILATION OF PAPERS TO READ

  • Division in Escherichia coli is triggered by a size-sensing rather than a timing mechanism[1]
  • Slow Protein Fluctuations Explain the Emergence of Growth Phenotypes and Persistence in Clonal Bacterial Populations [2]
  • Stress‐response balance drives the evolution of a network module and its host genome [3]
  • Emergent genetic oscillations in a synthetic microbial consortium [4]
  • Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms [5]
  • A noisy linear map underlies oscillations in cell size and gene expression in bacteria [6]
  • Replication of DNA in bacteria with heterogeneous generation times [7]
  • Duplication of the bacterial cell and its initiation [8]
  • Dilution of the cell cycle inhibitor Whi5 controls budding-yeast cell size [9]
  • A growth‐rate composition formula for the growth of E. coli on co‐utilized carbon substrates [10]
  • Macromolecular Crowding as a Regulator of Gene Transcription [11]
  • Cell Size and the Initiation of DNA Replication in Bacteria [12]
  • How fast-growing bacteria robustly tune their ribosome concentration to approximate growth-rate maximisation [13]
  • Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations [14]
  • Does evolutionary theory need a rethink? [15]
  • A cross-chiral RNA polymerase ribozyme [16]
  • Cell cycle: It takes three to find the exit [17]
  • Loss of growth homeostasis by genetic decoupling of cell division from biomass growth: implication for size control mechanisms [18]
  • Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation [19]
  • Cell dynamics and gene expression control in tissue homeostasis and development [20]
  • Quantitative evolutionary dynamics using high-resolution lineage tracking [21], with comment HERE
  • Conditional density-based analysis of T cell signaling in single-cell data [22]
  • Evolution of context dependent regulation by expansion of feast/famine regulatory proteins [23]
  • Carbon source-dependent expansion of the genetic code in bacteria [24]
  • Reducing the genetic code induces massive rearrangement of the proteome [25]
  • Conserved codon composition of ribosomal protein coding genes inEscherichia coli, Mycobacterium tuberculosis and Saccharomyces cerevisiae: lessons from supervised machine learning in functional genomics [26]

CONTACT INFORMATION

Please feel free to e-mail me if you would like to suggest another paper to discuss at the group:


Publications

  1. ISBN:9783527318742 [Klipp2009]

Useful Links

  • Introductory tutorial
  • OpenWetWare help pages
  • Link to the tutorial on adjusting images in Wikis.
  • Link to download the Wiki construction 'Cheat-Sheet' from my Dropbox. It details the simple commands needed to construct your Wiki pages.
  • Further advanced level of editing Cheat-Sheets can be found HERE.
  • Beware of copyright issues and fact that figures uploaded will fall under the Creative Commons license. Please see the following link.