Topp:Talks

Protein Stability and Formulation Lab

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Recent presentations

1. Formulating to optimize peptide physical and chemical stability. 2015 American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Orlando, FL, October 25-31, 2015.
2. Protein conformation in lyophilized solids by hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS). NIST/University of Maryland Biomanufacturing Summit, Rockville, MD, June 25, 2015.
3. High resolution characterization of glucagon fibrillation to design stable formulations. Colorado Protein Stability Conference, Beaver Run Resort, Breckenridge, CO, July 21-23, 2015.
4. Characterizing protein higher order structure in the design of lyophilized formulations. Gordon Conference, “Preclinical Form and Formulation in Drug Discovery”, Waterville Valley Resort, NH, June 7-12, 2015.
5. Effect of lyophilization on protein aggregation. 2015 Annual Meeting of the Midwest Chapter of the International Society for Lyophilization – Freeze Drying (ISLFD), Chicago, IL, April 9, 2015.
6. Ten tips for pre-tenure faculty. ADVANCE FAST workshop, Purdue University, West Lafayette, IN March 24, 2015.
7. Ten tips for pre-tenure faculty. ADVANCE FAST workshop, Purdue University, West Lafayette, IN March 24, 2015.
8. Protein conformation in lyophilized solids by hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS). BITC Roundtable, Genentech, South San Francisco, CA, February 3, 2015.
9. Leadership and the end of higher education. Union University, Jackson, TN, November 18-19, 2014.
10. Top ten tips for success as a woman in pharma. Women in Lilly Discovery and Development (WiLDD), Eli Lilly and Company, Indianapolis, IN, August 6, 2014.
11. High resolution characterization of proteins in formulation design. Roche, Basel, Switzerland, July 22, 2014.
12. High resolution structural characterization of proteins in amorphous solids: Hydrogen deuterium exchange and photolytic labeling with mass spectrometric analysis. AMORPH 2014, Cambridge, UK, July 14-16, 2014.
13. Leadership and the end of higher education. InterVarsity Midwest Faculty Conference, Cedar Campus, Cedarville, MI, June 22-27, 2014.
14. High resolution characterization of protein structure and interactions in formulation design. MedImmune, Gaithersburg, MD, June 10, 2014.
15. Protein aggregation: Mechanisms and characterization, Part I. PEGS: the Essential Protein Engineering Summit. Short Course 16: Protein Aggregation: Mechanism, Characterization and Immunogenic Consequences, Boston, MA, May 8, 2014.
16. Lyophilized formulations of protein drugs: Toward chemical definition of the amorphous solid state. University of Iowa, Department of Pharmaceutical Sciences and Experimental Therapeutics, Iowa City, IA, April 20, 2014.
17. High resolution structural characterization of proteins in lyophilized powders: Hydrogen deuterium exchange and photolytic labeling with mass spectrometric analysis. Baxter Pharmaceuticals, Inc., Bloomington, IN, April 16, 2014.
18. High resolution MS characterization of glucagon fibrillation to design stable formulations. American Association of Pharmaceutical Scientists Annual Meeting, San Diego, CA, November 2-6, 2014.
19. High resolution mass spectrometric monitoring of early aggregates. ECI Biological and Pharmaceutical Complex Fluids, Durham, NC, August 10-14, 2014.
20. Analytical challenges in detecting protein aggregates. CHI PepTalk, Palm Springs, CA, January 16, 2014.
21. Protein aggregation: Mechanisms and characterization, Part I. CHI PepTalk, Palm Springs, CA, January 14, 2014.
22. Intermolecular interactions in drug development. Lilly Tech Day, Eli Lilly and Company, Indianapolis, IN, September 30, 2013.
23. High resolution characterization of proteins in lyophilized powders. Pfizer, Inc., Pearl River, NY, September 11, 2013.
24. Ten tips for success as a woman in tech (WebEx). Seagate Women’s Leadership Network, August 26, 2013.
25. High resolution characterization of proteins in amorphous solid powders, E.M. Topp, L.K. Iyer, S.M. Balakrishnan and B. Xie, International Symposium on Polymer Analysis and Characterization, New Orleans, LA, June 9-12, 2013.
26. Challenges and opportunities in pharmacy. University of Wisconsin-Madison, School of Pharmacy, Madison, WI, April 8, 2013.
27. Aggregation of protein drugs: Risk assessment and mitigation strategies. University of Illinois Chicago, Chicago, IL, January 30, 2013.
28. Aggregation of protein drugs: Risk assessment and mitigation strategies. U.S. Food and Drug Administration, Center for Biologics Evaluation and Research (CBER), Rockville, MD, November 27, 2012.
29. Introduction to the Department of Industrial and Physical Pharmacy. Shenyang Pharmaceutical University, Shenyang, China, September 16, 2012.
30. Degradation of protein drugs: Mechanisms and risk assessment. Pfizer Global Supply Webex, September 4, 2012.
31. Optimizing protein-excipient interactions for the development of aggregation-reducing formulations. Brock C. Roughton, Anthony I. Pokphanh, Elizabeth M. Topp and Kyle V. Camarda, Symposium on Process Systems Engineering (PSE2012), Singapore, July 15-19, 2012. (in preparation)
32. Effects of lyophilization on protein drugs. 2012 Annual Meeting of the Midwest Chapter of the International Society for Lyophilization – Freeze Drying (ISLFD), Chicago, IL, April 12, 2012.
33. Aggregation of protein drugs. University of Kansas, Department of Chemical Engineering, Lawrence, KS, March 6, 2012.
34. Aggregation of protein drugs. University of Connecticut, College of Pharmacy, Storrs, CT, February 1, 2012.
35. Effects of lyophilization on protein chemical and physical properties. Abbott Laboratories, North Chicago, December 8, 2011.
36. Aggregation and stabilization of lyophilized proteins by excipients. Lavanya K. Iyer and Elizabeth M. Topp, Ninth Annual Garnet E. Peck Symposium in Industrial Pharmacy, Purdue University, West Lafayette, IN, October 20, 2011.
37. Thiol disulfide exchange and disulfide scrambling in peptides derived from human growth hormone. Saradha Chandrasekhar, Andreas Sophocleous and Elizabeth M. Topp, Ninth Annual Garnet E. Peck Symposium in Industrial Pharmacy, Purdue University, West Lafayette, IN, October 20, 2011.
38. Investigation of deuterium uptake kinetics in lyophilized myoglobin powders. Andreas Sophocleous and Elizabeth M. Topp, Gordon Research Conference, Biological Molecules in the Gas Phase and in Solution, Andover, NH, July 31-August 5, 2011.
39. Lyophilization-induced aggregation: A survey of structural properties of model proteins. Esben Bertelsen and Elizabeth M. Topp, Colorado Protein Stability Conference, Breckenridge, CO, July 19-21, 2011.
40. Aggregation and stabilization of lyophilized proteins by excipients. Lavanya K. Iyer and Elizabeth M. Topp, Pharmaceutics Graduate Students Research Meeting, Madison, WI, June 23-25, 2011.
41. Lyophilization-induced aggregation of model proteins. Esben Bertelsen and Elizabeth M. Topp. Pharmaceutics Graduate Students Research Meeting, Madison, WI, June 23-25, 2011.
42. Thiol-disulfide exchange and disulfide scrambling in peptides derived from human growth hormone. Saradha Chandresekhar and Elizabeth M. Topp. Pharmaceutics Graduate Students Research Meeting, Madison, WI, June 23-25, 2011.
43. Characterization of disulfide bond scrambling in human growth hormone induced by thermal stress, freeze-thaw cycling, agitation and lyophilization. Jun Zhang, Andreas Sophocleous and Elizabeth M. Topp. American Chemical Society National Meeting, Anaheim, CA, March 27-31, 2011.
44. Hydrogen-deuterium exchange study of myoglobin in solution and solid states. Andreas Sophocleous and Elizabeth M. Topp, Biophysical Society Meeting, Baltimore, MD, March, 2011.
45. Stabilization of human IgGs immobilized onto protein G agarose beads via affinity interaction. Jun Zhang and Elizabeth M. Topp. American Association of Pharmaceutical Scientists Annual Meeting, New Orleans, LA, November 14-18, 2010.
46. Use of aggregation prediction in the design of protein formulations. Brock C. Roughton, Anthony I. Pokphanh, T. Steele Reynolds, Jennifer Laurence, Elizabeth M. Topp, and Kyle.V. Camarda. American Institute of Chemical Engineers Annual Meeting, Salt Lake City, UT, November 7-12, 2010.
47. Stabilization of human IgGs by immobilization on Protein G agarose beads. Jun Zhang and Elizabeth M. Topp. Eighth Annual Garnet E. Peck Symposium in Industrial Pharmacy, Purdue University, West Lafayette, IN, October 14, 2010.
48. Stabilization of human IgGs by immobilization on Protein G agarose beads. Jun Zhang and Elizabeth M. Topp. 2010 Workshop on Protein Aggregation and Immunogenicity, Breckenridge, CO, July 20-22, 2010.
49. Hydrogen-deuterium exchange study of myoglobin in solution and solid states. Andreas Sophocleous and Elizabeth M. Topp, AAPS National Biotechnology Conference, San Francisco, CA, May 16-19, 2010.
50. Aggregation prediction in therapeutic protein formulations for excipient design. Brock C. Roughton, Anthony I. Pokphanh, T. Steele Reynolds, J. Laurence, E.M. Topp and K.V. Camarada. Missouri Regional Life Sciences Summit, Kansas City, MO, March 8-9, 2010.

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