Topp
Welcome to the Topp Lab wiki!
Our lab studies protein formulation and stability. Protein drugs are one of the fastest growing sectors of the biopharmaceutical industry, offering promising new treatments for difficult diseases. Proteins are fragile, though, and can degrade chemically and physically during manufacturing and storage. Degradation reduces potency and can increase the potential for serious side effects. Our goal is to develop rational methods for formulating peptide and protein drugs based on a mechanistic understanding of the chemical and physical degradation processes that can occur. We're particularly interested in amorphous solids. More than 40% of current protein drugs are solids, yet little is known about the factors that control reactions in the amorphous state.
Click the links above to learn more about our research, our group members and our recent activities. Thanks for visiting!
