Todd:PZQ Student Optimization: Difference between revisions
Matthew Todd (talk | contribs) (New page: {{Todd}} =Student-led Optimization of the Resolution of Praziquantel= '''New authors go here:''' Michael Woelfle,<sup>1</sup> Piero Olliaro<sup>2</sup> and Matthew H. Todd<sup>1</sup>*<b...) |
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==References== (Please include DOIs to any references provided)<br> | ==References== | ||
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Revision as of 02:45, 22 March 2011
Student-led Optimization of the Resolution of Praziquantel
New authors go here: Michael Woelfle,1 Piero Olliaro2 and Matthew H. Todd1*
1. School of Chemistry, The University of Sydney, NSW 2006, Australia
2. Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland
- To whom correspondence should be addressed: Tel. +61 2 9351 2180, matthew.todd@sydney.edu.au
Authors have contributed to the open electronic lab notebook where the original research was first disclosed.
Abstract
A preparation of enantiopure praziquantel was recently discovered that involves the classical resolution of a hydrolysis product, praziquanamine. The protocol is experimentally simple, and involves no chromatography. For the procedure to be of the greatest impact, the price must be kept very low, meaning that the process must be highly optimized. This paper describes the results obtained by a distributed group of students working on this problem in an open source manner.
Introduction
Description of the existing process Identification of current shortcomings Brief outline of how the project was intended to operate
Results and Discussion
Chemistry
How the collaboration worked
Methods and Materials
Hydrolysis of PZQ
Synthesis of Resolving Agents
The Resolution of PZQamine
Conversion of PZQamine to PZQ
References
(Please include DOIs to any references provided)
