Todd:Construction

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m (Open science papers being written by us and the people we work with)
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[[Todd:Asymmetric Hydrogenation of PZQ Enamide | Asymmetric Hydrogenation of PZQ Enamide]] - New paper describing results on the synthetic approach to (''R'')-PZQ based on an asymmetric hydrogenation of a precursor enamide.<br>
[[Todd:Asymmetric Hydrogenation of PZQ Enamide | Asymmetric Hydrogenation of PZQ Enamide]] - New paper describing results on the synthetic approach to (''R'')-PZQ based on an asymmetric hydrogenation of a precursor enamide.<br>
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[[Todd:The Lewis Acid-Catalysed Pictet-Spengler formation of Substituted 1,2,3,4-Tetrahydroisoquinolines|The Lewis Acid-Catalysed Pictet-Spengler formation of Substituted 1,2,3,4-Tetrahydroisoquinolines]] - Undergraduate project working towards the Lewis Acid catalysed asymmetric Pictet-Spengler reaction. Related to the Pictet-Spengler route to PZQ.<br>
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[[Todd:The Lewis Acid-Catalysed Pictet-Spengler Formation of Substituted 1,2,3,4-Tetrahydroisoquinolines|The Lewis Acid-Catalysed Pictet-Spengler Formation of Substituted 1,2,3,4-Tetrahydroisoquinolines]] - Undergraduate project working towards the Lewis Acid catalysed asymmetric Pictet-Spengler reaction. Related to the Pictet-Spengler route to PZQ.<br>
Papers here are being assembled in the open. Those who make/have made substantial contributions to the projects will be named on the papers, which will be submitted for publication as soon as they're finished. Rules for how this should operate will be posted below but will be adapted from those already established for the [http://polymathprojects.org/general-polymath-rules/ Polymath Project]
Papers here are being assembled in the open. Those who make/have made substantial contributions to the projects will be named on the papers, which will be submitted for publication as soon as they're finished. Rules for how this should operate will be posted below but will be adapted from those already established for the [http://polymathprojects.org/general-polymath-rules/ Polymath Project]

Revision as of 05:58, 8 June 2012

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Open science papers being written by us and the people we work with

Synthesis of Analogs of Arylpyrrole Antimalarial Drug Leads This is an undergraduate report describing the synthesis towards analogs of the arylpyrroles, TCMDC 123812 and TCMDC 123794. Raw data in Lablog here

Open Source Drug Discovery for Malaria - Highly Potent Compounds Derived from the GSK Arylpyrrole Set - The first paper arising from the open source malaria project.

Resolution of Praziquantel - this page is no longer being actively edited since it has been published.
Student-led Optimization of the Resolution of Praziquantel This paper is being written by students participating in the open project whose raw data are here.

Pictet-Spengler route to PZQ - Summary of the Lablog Pictet-Spengler route to Praziquantel

Catalytic, Asymmetric Pictet-Spengler Reaction - A review of the area.

Asymmetric Hydrogenation of PZQ Enamide - New paper describing results on the synthetic approach to (R)-PZQ based on an asymmetric hydrogenation of a precursor enamide.

The Lewis Acid-Catalysed Pictet-Spengler Formation of Substituted 1,2,3,4-Tetrahydroisoquinolines - Undergraduate project working towards the Lewis Acid catalysed asymmetric Pictet-Spengler reaction. Related to the Pictet-Spengler route to PZQ.


Papers here are being assembled in the open. Those who make/have made substantial contributions to the projects will be named on the papers, which will be submitted for publication as soon as they're finished. Rules for how this should operate will be posted below but will be adapted from those already established for the Polymath Project

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