Tamoxifen administration to mice

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One of the uses of tamoxifen in the lab is the activation of enzymes deactivated via an estrogen-binding domain, like Cre-ER (Cre-LBD). Tamoxifen is an estrogen analogue that binds with higher affinity than estrogen to altered estrogen binding domains.

Tamoxifen is administered to mice in 2 main ways: via the drinking water or in an oily mix given via a feeding needle. Administration via the drinking water is easier but somewhat less reliable.

Contents

Chemical data for tamoxifen citrate

molecular weight pKa' equilibrium solubility in water at 37°C
563.62 g/mol 8.85 0.5 mg/mL

see [1]

Tamoxifen administration via the drinking water

Tamoxifen administration via a feeding needle

See also

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