Talk:CH391L/S13/Phage Therapy

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  • Gabriel Wu 17:23, 25 March 2013 (EDT): Is there a review (in English) of all these Russian studies?
    • Neil R Gottel 13:48, 26 March 2013 (EDT):Yep! Its my first reference. I'll make a note in the article about that.
  • Jeffrey E. Barrick 21:34, 25 March 2013 (EDT):Phage therapy turns up in early 20th century novel about science by Sinclair Lewis: Arrowsmith (not to be confused with Upton Sinclair of The Jungle).
    • Neil R Gottel 13:48, 26 March 2013 (EDT):Cool! Wikipedia says its the earliest novel to focus on scientific culture. We should discuss it at the inaugural meeting of the Barrick Lab Book Club.
      • Jeffrey E. Barrick 23:21, 28 March 2013 (EDT):The inaugural slot is already reserved for Moby Dick.
  • Catherine I. Mortensen 14:43, 26 March 2013 (EDT):There's always a chance that bacteria can mutate and become resistant to antibiotics such as amoxicillin. What if viruses were used to reverse bacterial resistance to certain antibiotics in combination with antibiotics... so phage therapy and antibiotics used together. This would really kill a disease. Here's an article about reversing bacterial resistance to antibiotics [1]
    • Kevin Baldridge 11:25, 28 March 2013 (EDT):Cool idea, I like their application idea for using it as a surface disinfectant in high-risk areas for antibiotic resistance, i.e. hospitals. However, I wonder how long it will be effective before bacteria adapt a response to the phage? They adapted to antibiotics, and we know they have an innate "immune system" CRISPR paper in Science 2007 which helps them adapt to viral assault.
    • Jeffrey E. Barrick 23:21, 28 March 2013 (EDT):Like the paper. It seems like it would be hard to get any system for adding a gene to existing organisms so effective that it would make 100% of them susceptible to an antibiotic.
  • Jeffrey E. Barrick 23:21, 28 March 2013 (EDT):Neil, you make it sound like it's easy to find or create a phage capable of killing any bacterium. Where do I find the phage that I use to tailor my microbiota? Are there any groups of bacteria that just don't get infected by phage?

Thomas Wall 23:21, 28 March 2013 (EDT): So this wasn't the article I was looking for, I remember reading one on clostridium difficile (http://www.pnas.org/content/early/2012/10/04/1206136109). But, this sort of thing led me to wondering if we could engineer probiotic mixtures to make phage against all kinds of things we don't want in our guts.

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