Talk:CH391L/S12/Artemisinic Acid Engineering

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(New page: *'''~~~~''':Looks like you have the new reports of resistance to Artemisinin covered. Do they know what the mutations are and why they make it resistant?)
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*'''[[User:Jeffrey E. Barrick|Jeffrey E. Barrick]] 12:41, 15 April 2012 (EDT)''':History of the compound is very interesting and well done. It might be good to give a short background or link to how malaria works. What kind of organism is ''Plasmodium''? How does an infection progress?
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*'''[[User:Jeffrey E. Barrick|Jeffrey E. Barrick]] 12:41, 15 April 2012 (EDT)''':Great description of their work. There is an earlier paper published about a checkpoint in their engineering efforts where they appear to have been moving the yeast enzymes to ''E. coli'' to get it to produce artemisinin. Is this evidence that they were evaluating multiple chassis and had to switch to yeast later?<cite>Martin2003</cite>.
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*'''[[User:Jeffrey E. Barrick|Jeffrey E. Barrick]] 12:18, 15 April 2012 (EDT)''':Looks like you have the new reports of resistance to Artemisinin covered. Do they know what the mutations are and why they make it resistant?
*'''[[User:Jeffrey E. Barrick|Jeffrey E. Barrick]] 12:18, 15 April 2012 (EDT)''':Looks like you have the new reports of resistance to Artemisinin covered. Do they know what the mutations are and why they make it resistant?
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*'''[[User:Jeffrey E. Barrick|Jeffrey E. Barrick]] 12:41, 15 April 2012 (EDT)''':It's usually good to avoid value judgements, like calling something "famous", in scientific or formal writing.
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== References ==
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<biblio>
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#Martin2003 pmid=12778056
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</biblio>

Revision as of 12:41, 15 April 2012

  • Jeffrey E. Barrick 12:41, 15 April 2012 (EDT):History of the compound is very interesting and well done. It might be good to give a short background or link to how malaria works. What kind of organism is Plasmodium? How does an infection progress?
  • Jeffrey E. Barrick 12:41, 15 April 2012 (EDT):Great description of their work. There is an earlier paper published about a checkpoint in their engineering efforts where they appear to have been moving the yeast enzymes to E. coli to get it to produce artemisinin. Is this evidence that they were evaluating multiple chassis and had to switch to yeast later?[1].
  • Jeffrey E. Barrick 12:18, 15 April 2012 (EDT):Looks like you have the new reports of resistance to Artemisinin covered. Do they know what the mutations are and why they make it resistant?
  • Jeffrey E. Barrick 12:41, 15 April 2012 (EDT):It's usually good to avoid value judgements, like calling something "famous", in scientific or formal writing.

References

  1. Martin VJ, Pitera DJ, Withers ST, Newman JD, and Keasling JD. . pmid:12778056. PubMed HubMed [Martin2003]
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