THF

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Contents

Name

Tetrahydrofuran

Use

Heterocyclic compound implicated in organic synthesis of unnatural amino acids, and most importantly as a miscible (anhydrous) reagent to synthetize N-substituted phenoxyalkylamines (ligands) using orthogonal (multi-step) catalysis of dicarboxilic protected C=C ions (amines) in liquid phase PTC/Ion chromatography.

N-substituted (cis/trans) phenoxyalkylation using Michael reaction of complex amino acids

  • a "alkane isomerisation" type of organic catalysis 1
    • Etienne Robillard 10:35, 15 January 2013 (EST) Can aromatic nucleophilic substitution of a disubstituted phenoxyalkylamine produce para/ortho opioid ligand (L-dopamine for example) ? In this case, verify if the N heterocycle ring is acting as the nucleophile (R) reagent in presence of an aldehyde...
      • Etienne Robillard 10:35, 15 January 2013 (EST) See also "Michael reaction" for a proper explanation.. :)
  • isopropanol can donate proton -- an aldehyde like solvent?
    • Etienne Robillard 10:35, 15 January 2013 (EST) Can THF donate stuff with nucleophilic rings? ie cyclohexanoyl
  • alkane isomerisation = organic synthesis: L-dopamine, cyclohexylamine, etc..
  • Ethics of producing novel opioid receptor agonist compounds for human-specific psychotropic experiments?
    • Etienne Robillard 10:35, 15 January 2013 (EST) Heck, is there a possibility theses novel psychotropic compounds be used by terrorist groups to terrorize unwary citizens with psychological warfare using unconventional (synthetic) "devices" ?

Related chemicals

References

1. Kim J., Recent Advances in Asymmetric Phase-Transfer-Catalysis, 2011 http://stoltz.caltech.edu/seminars/2011_Kim.pdf p. [1-25]

See also

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