TABASCO: Difference between revisions
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== Summary == | == Summary == | ||
Tabasco is a simulator created to address the problem of simulating gene expression at single-base resolution. Tabasco avoids previous ‘combinatorial explosion’ problems by tracking the position and state of proteins and genetic elements on the DNA to dynamically generate appropriate reactions, such as promoters being blocked by traversing polymerases. In order to improve computational efficiency, Tabasco makes use of a Gibson-accelerated Gillespie SSA to compute the reaction event timing and the resultant time-evolution of the genetic system. | Tabasco is a simulator created to address the problem of simulating gene expression at single-base resolution. Tabasco avoids previous ‘combinatorial explosion’ problems by tracking the position and state of proteins and genetic elements on the DNA to dynamically generate appropriate reactions, such as promoters being blocked by traversing polymerases. In order to improve computational efficiency, Tabasco makes use of a Gibson-accelerated Gillespie SSA to compute the reaction event timing and the resultant time-evolution of the genetic system. | ||
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== Goals == | == Goals == | ||
== Results == | |||
== Code == | |||
Revision as of 13:59, 24 May 2005
Summary
Tabasco is a simulator created to address the problem of simulating gene expression at single-base resolution. Tabasco avoids previous ‘combinatorial explosion’ problems by tracking the position and state of proteins and genetic elements on the DNA to dynamically generate appropriate reactions, such as promoters being blocked by traversing polymerases. In order to improve computational efficiency, Tabasco makes use of a Gibson-accelerated Gillespie SSA to compute the reaction event timing and the resultant time-evolution of the genetic system.
People
Sriram Kosuri Jason Kelly Drew Endy
