TABASCO

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== Summary ==
== Summary ==
Tabasco is a simulator created to address the problem of simulating gene expression at single-base resolution.  Tabasco avoids previous ‘combinatorial explosion’ problems by tracking the position and state of proteins and genetic elements on the DNA to dynamically generate appropriate reactions, such as promoters being blocked by traversing polymerases.  In order to improve computational efficiency, Tabasco makes use of a Gibson-accelerated Gillespie SSA to compute the reaction event timing and the resultant time-evolution of the genetic system.
Tabasco is a simulator created to address the problem of simulating gene expression at single-base resolution.  Tabasco avoids previous ‘combinatorial explosion’ problems by tracking the position and state of proteins and genetic elements on the DNA to dynamically generate appropriate reactions, such as promoters being blocked by traversing polymerases.  In order to improve computational efficiency, Tabasco makes use of a Gibson-accelerated Gillespie SSA to compute the reaction event timing and the resultant time-evolution of the genetic system.
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== Goals ==
== Goals ==
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== Results ==
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== Code ==

Revision as of 15:59, 24 May 2005

Contents

Summary

Tabasco is a simulator created to address the problem of simulating gene expression at single-base resolution. Tabasco avoids previous ‘combinatorial explosion’ problems by tracking the position and state of proteins and genetic elements on the DNA to dynamically generate appropriate reactions, such as promoters being blocked by traversing polymerases. In order to improve computational efficiency, Tabasco makes use of a Gibson-accelerated Gillespie SSA to compute the reaction event timing and the resultant time-evolution of the genetic system.

People

Sriram Kosuri Jason Kelly Drew Endy

Goals

Results

Code

Personal tools