Synthetic Biology:Semantic web ontology/Examples
From OpenWetWare
Ontology - essentially, a formal description of objects and their interrelationships Described using RDF Schema and/or OWL.
Examples:
- Dublin Core provides a vocabulary to describe bibliographic metadata
- Namespace: http://purl.org/dc/elements/1.1/
- Properties: title, creator, publisher, identifier
- Gene Ontology provides a controlled vocabulary to describe gene and gene product attributes in any organism. GO terms are organized in directed acyclic graphs (DAGs), which differ from hierarchies in that a 'child' (more specialized term) can have many 'parents' (less specialized terms). GO terms are connected by 'is a' (generalizations) and 'part of' (composition) relationships.
- Namespace: ftp://ftp.geneontology.org/pub/go/xml/dtd/go.dtd
- Properties: name, definition, isa, association, evidence
- Sequence Ontology: features on a nucleotide or protein sequence
- BioPAX: biological pathway data
- UniProt (planning)
- SBML uses CellML metadata to describe its elements. See also a message on SBML forum.
- BioModels database and Systems Biology Ontologies (SBO) project
- Open Biomedical Ontologies
- Bio-Ontologies
- Ontologies for molecular biology and bioinformatics
- Microarray Gene Expression Society (MGED) Ontology
Diagram of synthetic biology ontology v0.01 (developed using existing terminology described on the Registry website):
Resources
- GO annotation wiki (from Sri)
- RDF Schemas directory
- Ontology Development 101: A Guide to Creating Your First Ontology
- Protégé OWL Tutorial
Software
- Ontology editors
- Protégé is a free, open source ontology editor and knowledge-base framework
- OilEd is an ontology editor allowing the user to build ontologies using DAML+OIL
- Ontolingua
- Chimaera is a software system that supports users in creating and maintaining distributed ontologies on the web