Synthetic Biology:Semantic web ontology: Difference between revisions

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This is a part of the effort to provide a standardized, extensible, scalable and '''machine-processable''' interface for the [http://parts.mit.edu/ Registry of Standard Biological Parts].
{{Synthetic biology top}}


==Semantic Web==
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RDF/XML, RDF Schema and OWL


*allows to model real things, not just documents or database tables
==Overview==
*consists of statements about resources in the form of triples:
This is a part of the effort to provide a standardized, extensible, scalable and machine-processable interface for the [http://parts.mit.edu/ Registry of Standard Biological Parts]. Semantic Web technologies seem to provide a solution to this problem. The success of developing a Synthetic Biology ontology depends in part on a good definition of the [[Synthetic Biology:Abstraction hierarchy | BioBricks abstraction hierarchy]].
SUBJECT -> PROPERTY -> VALUE
*identifies every resource with a globally unique URI: don't say "color", say <http://example.com/2005/std6#col>
*allows “serendipitous reuse”: integration with data sources in other fields (“web join”)


==Ontology==
==Meetings==
Controlled vocabulary of concepts and their relationships.
*First meeting
:Tuesday (9/20/05) at 3pm, room 68-674; [[Synthetic Biology:SWO1minutes|minutes]]
*Second meeting
:Friday (9/23/05) at 10am, room 68-121; [[Synthetic Biology:SWO2minutes|minutes]]


Examples of ontologies:
==Resources==
#Dublin Core
*[[Synthetic_Biology:Semantic_web_ontology/Design|Design]]
#*Namespace: http://purl.org/dc/elements/1.1/
*[[Synthetic_Biology:Semantic_web_ontology/Semantic_Web|Semantic Web]]
#*Properties: title, creator, publisher, identifier
**[[Synthetic_Biology:Semantic_web_ontology/RDF|RDF]]
#Gene Ontology
**[[Synthetic_Biology:Semantic_web_ontology/RDF_Schema|RDF Schema]]
#*Namespace: ftp://ftp.geneontology.org/pub/go/xml/dtd/go.dtd
**[[Synthetic_Biology:Semantic_web_ontology/OWL|OWL]]
#*Properties: name, definition, isa, association, evidence
**[[Synthetic_Biology:Semantic_web_ontology/Query|Query Languges]]
#Sequence Ontology: features on a nucleotide or protein sequence
**[[Synthetic_Biology:Semantic_web_ontology/SWRL|Rule Languages (SWRL)]]
#BioPAX: biological pathway data
*[[Synthetic_Biology:Semantic_web_ontology/Web Services|Web Services]]
#UniProt (planning)
*[[Synthetic_Biology:Semantic_web_ontology/REST|REST]]
*[[Synthetic_Biology:Semantic_web_ontology/Agents|Agents]]
*[[Synthetic_Biology:Semantic_web_ontology/Examples|Examples]]
*[[Synthetic_Biology:Semantic_web_ontology/Software|Software]]
*[[Synthetic_Biology:Semantic_web_ontology/Knowledge_representation|Knowledge representation]]


[http://sbml.org/documents/ SBML] uses [http://www.cellml.org/specifications/archive/metadata/20011102/cellml_metadata_specification.html CellML metadata] to describe its elements. See also a [http://www.sbml.org/forums/index.php?t=msg&goto=1435&rid=0#msg_1435 message] on SBML forum.
==Miscellaneous==
*[http://www.w3.org/TR/webarch/ Architecture of the World Wide Web, Volume One]
*[http://www.w3.org/DesignIssues/Overview.html Design Issues for the World Wide Web]
**[http://www.w3.org/DesignIssues/HTTP-URI.html What do HTTP URIs Identify?]
*[http://dig.csail.mit.edu/ Decentralized Information Group] @ CSAIL
*[http://www.nodalpoint.org/node/1645 Object-oriented biology] - application of object-oriented paradigm to Gene (from nodalpoint.org)
*[http://www.synberc.org/ SynBERC]: [[SynBERC|Synthetic Biology Engineering Research Center]] is a multi-institution research effort to lay the foundation for synthetic biology, which aims to build biological components and assemble them into integrated systems to accomplish specific tasks
**[[SynBERC:MIT|MIT SynBERC]]
*[[Registry_of_Standard_Biological_Models|Registry of Standard Biological Models]]
*[[DOI|DOI & LSID info]]
*[http://researchweb.watson.ibm.com/journal/sj/402/haas.html IBM DiscoveryLink] provides users with a virtual database to which they can pose arbitrarily complex queries, even though the actual data needed to answer the query may originate from several different sources, and none of those sources, by itself, is capable of answering the query (data integration)
*[http://mitdatacenter.org/ The Data Center at the Massachusetts Institute of Technology] is a new initiative charged with researching and developing the languages, protocols, and technologies to integrate data and models across global networks.


Biomodels database and Systems Biology Ontologies (SBO) project
Contact: [[User:Ilya|Ilya Sytchev]]
http://biomodels.net/


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[http://dimer.tamu.edu/GO/wiki GO annotation wiki] (from [[User:Skosuri|Sri]]).
{{Synthetic biology bottom}}
 
GO (terms describing process)
DAG-Edit - ontology viewer
https://sourceforge.net/projects/geneontology/
BioPAX
 
 
 
References:
#[http://www.w3.org/2005/Talks/0517-boit-tbl/ Berners-Lee - Semantic Web Life Sciences - BioIT World]
#[http://www.w3.org/2003/Talks/05-gartner-tbl/ Web Service - Semantic Web by Tim-Berners Lee]
#[http://www.amk.ca/talks/2004-12-02/ Introduction to the Semantic Web and RDF by A.M. Kuchling]

Latest revision as of 00:31, 26 September 2007

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Overview

This is a part of the effort to provide a standardized, extensible, scalable and machine-processable interface for the Registry of Standard Biological Parts. Semantic Web technologies seem to provide a solution to this problem. The success of developing a Synthetic Biology ontology depends in part on a good definition of the BioBricks abstraction hierarchy.

Meetings

  • First meeting
Tuesday (9/20/05) at 3pm, room 68-674; minutes
  • Second meeting
Friday (9/23/05) at 10am, room 68-121; minutes

Resources

Miscellaneous

Contact: Ilya Sytchev

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