SynBERC:Seminar series/Remy Chait: Difference between revisions
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'''Antibacterial drug combinations and evolution of drug resistance'''<br> | '''Antibacterial drug combinations and evolution of drug resistance'''<br> | ||
'''Remy Chait'''<br> | '''Remy Chait, Harvard Systems Biology'''<br> | ||
April 24, 2007<br> | April 24, 2007<br> | ||
12-1pm<br> | 12-1pm<br> | ||
Revision as of 14:15, 29 March 2007
Antibacterial drug combinations and evolution of drug resistance
Remy Chait, Harvard Systems Biology
April 24, 2007
12-1pm
68-181, MIT
The rapid evolution of bacterial drug resistance and the alarming slowdown in development of new antibiotics is spurring attention towards multi-drug treatments. But how do such treatments affect the rate of evolution of drug resistance? I will present a simple model and direct experimental measurements showing that non-additive interactions between the drugs can profoundly alter the fitness landscape, leading to surprising and counterintuitive outcomes.
