SynBERC:Seminar series/Remy Chait

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The rapid evolution of bacterial drug resistance and the alarming slowdown in development of new antibiotics is spurring attention towards multi-drug treatments. But how do such treatments affect the rate of evolution of drug resistance? I will present a simple model and direct experimental measurements showing that non-additive interactions between the drugs can profoundly alter the fitness landscape, leading to surprising and counterintuitive outcomes.
The rapid evolution of bacterial drug resistance and the alarming slowdown in development of new antibiotics is spurring attention towards multi-drug treatments. But how do such treatments affect the rate of evolution of drug resistance? I will present a simple model and direct experimental measurements showing that non-additive interactions between the drugs can profoundly alter the fitness landscape, leading to surprising and counterintuitive outcomes.
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See also the [http://www.nature.com/nature/journal/v446/n7136/abs/nature05685.html relevant publication].
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==Reference==
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<biblio>
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#Chait-Nature-2007 pmid=17410176
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</biblio>
==Remote participation==
==Remote participation==
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This talk will be webcast and video archived online (barring technical difficulties).  Details coming soon.
 
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To submit questions during the talk, you must have an [[Join|OpenWetWare account]].  Type questions into the [[Special:Chat |chat room]].
To submit questions during the talk, you must have an [[Join|OpenWetWare account]].  Type questions into the [[Special:Chat |chat room]].
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A video stream of the talk will be available for real-time viewing.  Just point Quicktime or [http://www.videolan.org/vlc/ VLC] to the following stream:
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'''rtsp://caprica.csail.mit.edu/SynBERC.sdp'''
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===Archived video===
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Download the talk in [http://blip.tv/file/get/Synberc-SynBERCSeminarSeriesRemyChait24April2007819.mp4 quicktime format here], or go to [http://blip.tv/file/210435 blip.tv] to see comments, get code to embed the video in your own webpage or blog (also visible by editing this page and looking below), and to watch or download the talk in alternate video formats (i.e. .flv).  Or just watch it here:
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<html>
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<center> <script type="text/javascript" src="http://blip.tv/scripts/pokkariPlayer.js"></script><script type="text/javascript" src="http://blip.tv/syndication/write_player?skin=js&posts_id=214769&source=3&autoplay=true&file_type=mov&player_width=0&player_height=0"></script><div id="blip_movie_content_214769"><a href="http://blip.tv/file/get/Synberc-SynBERCSeminarSeriesRemyChait24April2007819.mp4" onclick="play_blip_movie_214769(); return false;"><img src="http://blip.tv/file/get/Synberc-SynBERCSeminarSeriesRemyChait24April2007819.mp4.jpg" border="0" title="Click To Play" /></a><br /><a href="http://blip.tv/file/get/Synberc-SynBERCSeminarSeriesRemyChait24April2007819.mp4" onclick="play_blip_movie_214769(); return false;">Click To Play</a></div> </center>
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</html>

Current revision

Antibacterial drug combinations and evolution of drug resistance
Remy Chait, Harvard Systems Biology
April 24, 2007
12-1pm
68-181, MIT

The rapid evolution of bacterial drug resistance and the alarming slowdown in development of new antibiotics is spurring attention towards multi-drug treatments. But how do such treatments affect the rate of evolution of drug resistance? I will present a simple model and direct experimental measurements showing that non-additive interactions between the drugs can profoundly alter the fitness landscape, leading to surprising and counterintuitive outcomes.

Reference

  1. Chait R, Craney A, and Kishony R. . pmid:17410176. PubMed HubMed [Chait-Nature-2007]

Remote participation

To submit questions during the talk, you must have an OpenWetWare account. Type questions into the chat room.

A video stream of the talk will be available for real-time viewing. Just point Quicktime or VLC to the following stream:

rtsp://caprica.csail.mit.edu/SynBERC.sdp


Archived video

Download the talk in quicktime format here, or go to blip.tv to see comments, get code to embed the video in your own webpage or blog (also visible by editing this page and looking below), and to watch or download the talk in alternate video formats (i.e. .flv). Or just watch it here:

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