Stephanopoulos:Projects: Difference between revisions

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= <font style="color:maroon">Research</font> =


Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
<b>a)</b> the modification of biochemical pathways inside cells and
<b>b)</b> the rigorous evaluation of the resulting cellular phenotypes.


=== Our most recent research has been focused on the following topics: ===
# '''The modification of biochemical pathways inside cells''', and
* Metabolic Engineering of <i>E.Coli</i> for the production of biochemicals
# '''The rigorous evaluation of the resulting cellular phenotypes.'''


* Inverse Metabolic Engineering
Our most recent research has been focused on the following topics:


* gTME
:* [[Stephanopoulos:Production of biochemicals in E. coli | '''Metabolic Engineering of <i>E.Coli</i> for the production of biochemicals''']]


* Flux Determination
:* [[Stephanopoulos:Inverse Metabolic Engineering | '''Inverse Metabolic Engineering''']]


* Hepatocyte Physiology
:* [[Stephanopoulos:gTME | '''gTME''']]


* Metabolomics
:* [[Stephanopoulos:Flux Determination | '''Flux Determination''']]


* Systems Biology
:* [[Stephanopoulos:Hepatocyte Physiology | '''Hepatocyte Physiology''']]


:* [[Stephanopoulos:Metabolomics | '''Metabolomics''']]


                <br>
:* [[Stephanopoulos:Rational Drug Design | '''Rational Drug Design''']]
            To accomplish the above goals we make use of a diverse array of scientific tools and
methods, many of which have also become areas of research for our group:
                <ul>
                <p>
                <li>
                <b><a href="Bioinfo.shtml">Bioinformatics and Systems Biology</a></b> - Our group was
one of the first to realize the importance of computational tools for handling the
large volume of data generated by microarrays and other technologies.
                <li>
<b><a href="Fluxes.shtml">Methods for intracellular flux determination</a></b>
                - Fluxes are determined by material balancing, NMR fine spectra analysis and
GC-MS measurements.
                <li>
                <b><a href="Microarray.shtml">DNA microarrays</a></b> - We have developed full
genome microarrays for <i>Synechocystis</i> Sp., and partial microarrays for
                <i>C. glutamicum</i>, <i>E. coli</i>, and the mouse genomes.
                <li>
                <b><a href="BioReactor.shtml">Bioreaction network analysis.</a></b>
<br>


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:* [[Stephanopoulos:Systems Biology | '''Systems Biology''']]
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To accomplish the above goals we make use of a diverse array of scientific tools and
  <tr><td align="left" width="250" valign="top">
methods, many of which have also become areas of research for our group:
      <font color="maroon"><tt>Address</tt></font><br>
 
      <small>
:* [[Stephanopoulos:Bioinformatics and Systems Biology | '''Bioinformatics and Systems Biology''']] - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
Massachusetts Institute of Technology<br>
 
Department of Chemical Engineering<br>
:* [[Stephanopoulos:Methods for intracellular flux determination | '''Methods for intracellular flux determination''']] - Fluxes are determined by material balancing, NMR fine spectra analysis and GC-MS measurements.
Cambridge, MA 02139<br>
 
Room 56-469
:* [[Stephanopoulos:DNA microarrays | '''DNA microarrays''']] - We have developed full genome microarrays for ''Synechocystis'' Sp., and partial microarrays for ''C. glutamicum'', ''E. coli'', and the mouse genomes.  
      </small>
 
  </td>
:* [[Stephanopoulos:Bioreaction network analysis | '''Bioreaction network analysis''']]
  <td align="center" width="250" valign="top">
 
      <small>
|}
<a href="http://www.mit.edu">MIT</a> | <a href="/wiki/Stephanopoulos_Lab">HOME</a><br>
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Last Modified:<br>Monday, July 10th, 2006 - by <a href="Adrian.shtml">afi</a>.
      </small>
      <br>
      <font color="#990000"><tt>gnswebpage-www@mit.edu</tt></font>
  </td>
  <td align="right" width="250" valign="top">
      <font color="#990000"><tt>Telephones</tt><br></font>
      <small>
office | 617.258.0398<br>
lab | 617.253.6591<br>
lab | 617.258.0349<br>
lab | 617.253.6521<br>
fax | 617.253.3122<br>
      </small>
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Latest revision as of 15:30, 17 July 2007

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Research

Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:

  1. The modification of biochemical pathways inside cells, and
  2. The rigorous evaluation of the resulting cellular phenotypes.


Our most recent research has been focused on the following topics:


To accomplish the above goals we make use of a diverse array of scientific tools and methods, many of which have also become areas of research for our group:

  • Bioinformatics and Systems Biology - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
  • DNA microarrays - We have developed full genome microarrays for Synechocystis Sp., and partial microarrays for C. glutamicum, E. coli, and the mouse genomes.
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