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<align=left><h1 style="color:maroon">Research</h1></align>
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Our research is focused on Metabolic Engineering - the improvement of cellular
Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
properties, using modern genetic tools. This field encompasses two important components:
<b>a)</b> the modification of biochemical pathways inside cells and <b>b)</b> the rigorous
evaluation of the resulting cellular phenotypes.
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In recent years our group has investigated
the following topics:
                <ul>
<li><b><a href="Coryne.shtml">Aminoacid biosynthesis in
                <i>Corynebacterium glutamicum</i>.</b></a>


<li><b><a href="Rhodo.shtml">Indene bioconversion in
# '''The modification of biochemical pathways inside cells''', and
<i>Rhodococcus </i>Sp.</b></a>
# '''The rigorous evaluation of the resulting cellular phenotypes.'''


<li><b><a href="Synecho.shtml">CO<sub>2</sub> fixation and
Our most recent research has been focused on the following topics:
product synthesis by the cyanobacterium <i>Synechocystis</i> Sp.</b></a>
 
:* [[Stephanopoulos:Production of biochemicals in E. coli | '''Metabolic Engineering of <i>E.Coli</i> for the production of biochemicals''']]
                <li><b><a href="Diabetes.shtml">Elucidating type II diabetes by
 
                linking the expression and metabolic phenotypes of hepatoma and hepatocyte
:* [[Stephanopoulos:Inverse Metabolic Engineering | '''Inverse Metabolic Engineering''']]
                cells.</b></a>
 
                </ul>
:* [[Stephanopoulos:gTME | '''gTME''']]
               
 
            To accomplish the above goals we make use of a diverse array of scientific tools and
:* [[Stephanopoulos:Flux Determination | '''Flux Determination''']]
methods, many of which have also become areas of research for our group:
 
                <ul>
:* [[Stephanopoulos:Hepatocyte Physiology | '''Hepatocyte Physiology''']]
                <p>
 
                <li>
:* [[Stephanopoulos:Metabolomics | '''Metabolomics''']]
                <b><a href="Bioinfo.shtml">Bioinformatics and Systems Biology</a></b> - Our group was
 
one of the first to realize the importance of computational tools for handling the
:* [[Stephanopoulos:Rational Drug Design | '''Rational Drug Design''']]
large volume of data generated by microarrays and other technologies.
 
                <li>
:* [[Stephanopoulos:Systems Biology | '''Systems Biology''']]
<b><a href="Fluxes.shtml">Methods for intracellular flux determination</a></b>
 
                - Fluxes are determined by material balancing, NMR fine spectra analysis and
 
GC-MS measurements.
To accomplish the above goals we make use of a diverse array of scientific tools and
                <li>
methods, many of which have also become areas of research for our group:
                <b><a href="Microarray.shtml">DNA microarrays</a></b> - We have developed full  
 
genome microarrays for <i>Synechocystis</i> Sp., and partial microarrays for
:* [[Stephanopoulos:Bioinformatics and Systems Biology | '''Bioinformatics and Systems Biology''']] - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
                <i>C. glutamicum</i>, <i>E. coli</i>, and the mouse genomes.  
 
                <li>
:* [[Stephanopoulos:Methods for intracellular flux determination | '''Methods for intracellular flux determination''']] - Fluxes are determined by material balancing, NMR fine spectra analysis and GC-MS measurements.
                <b><a href="BioReactor.shtml">Bioreaction network analysis.</a></b>
 
</body>
:* [[Stephanopoulos:DNA microarrays | '''DNA microarrays''']] - We have developed full genome microarrays for ''Synechocystis'' Sp., and partial microarrays for ''C. glutamicum'', ''E. coli'', and the mouse genomes.  
</html>
 
:* [[Stephanopoulos:Bioreaction network analysis | '''Bioreaction network analysis''']]
 
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Latest revision as of 15:30, 17 July 2007

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Research

Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:

  1. The modification of biochemical pathways inside cells, and
  2. The rigorous evaluation of the resulting cellular phenotypes.


Our most recent research has been focused on the following topics:


To accomplish the above goals we make use of a diverse array of scientific tools and methods, many of which have also become areas of research for our group:

  • Bioinformatics and Systems Biology - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
  • DNA microarrays - We have developed full genome microarrays for Synechocystis Sp., and partial microarrays for C. glutamicum, E. coli, and the mouse genomes.
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