Stephanopoulos:Projects: Difference between revisions

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= <font style="color:maroon">Research</font> =
= <font style="color:maroon">Research</font> =


Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:


:* '''The modification of biochemical pathways inside cells''', and
# '''The modification of biochemical pathways inside cells''', and
:* '''The rigorous evaluation of the resulting cellular phenotypes.'''
# '''The rigorous evaluation of the resulting cellular phenotypes.'''
   
   


Our most recent research has been focused on the following topics:
Our most recent research has been focused on the following topics:


:* [[Stephanopoulos Lab:Production of biochemicals in E. coli | '''Metabolic Engineering of <i>E.Coli</i> for the production of biochemicals''']]
:* [[Stephanopoulos:Production of biochemicals in E. coli | '''Metabolic Engineering of <i>E.Coli</i> for the production of biochemicals''']]


:* [[Stephanopoulos Lab:Inverse Metabolic Engineering | '''Inverse Metabolic Engineering''']]
:* [[Stephanopoulos:Inverse Metabolic Engineering | '''Inverse Metabolic Engineering''']]


:* [[Stephanopoulos Lab:gTME | '''gTME''']]
:* [[Stephanopoulos:gTME | '''gTME''']]


:* [[Stephanopoulos Lab:Flux Determination | '''Flux Determination''']]
:* [[Stephanopoulos:Flux Determination | '''Flux Determination''']]


:* [[Stephanopoulos Lab:Hepatocyte Physiology | '''Hepatocyte Physiology''']]
:* [[Stephanopoulos:Hepatocyte Physiology | '''Hepatocyte Physiology''']]


:* [[Stephanopoulos Lab:Metabolomics | '''Metabolomics''']]
:* [[Stephanopoulos:Metabolomics | '''Metabolomics''']]


:* [[Stephanopoulos Lab:Rational Drug Design | '''Rational Drug Design''']]
:* [[Stephanopoulos:Rational Drug Design | '''Rational Drug Design''']]


:* [[Stephanopoulos Lab:Systems Biology | '''Systems Biology''']]
:* [[Stephanopoulos:Systems Biology | '''Systems Biology''']]




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methods, many of which have also become areas of research for our group:
methods, many of which have also become areas of research for our group:


:* [[Stephanopoulos Lab:Bioinformatics and Systems Biology | '''Bioinformatics and Systems Biology''']] - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
:* [[Stephanopoulos:Bioinformatics and Systems Biology | '''Bioinformatics and Systems Biology''']] - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.


:* [[Stephanopoulos Lab:Methods for intracellular flux determination | '''Methods for intracellular flux determination''']] - Fluxes are determined by material balancing, NMR fine spectra analysis and GC-MS measurements.
:* [[Stephanopoulos:Methods for intracellular flux determination | '''Methods for intracellular flux determination''']] - Fluxes are determined by material balancing, NMR fine spectra analysis and GC-MS measurements.


:* [[Stephanopoulos Lab:DNA microarrays | '''DNA microarrays''']] - We have developed full genome microarrays for ''Synechocystis'' Sp., and partial microarrays for ''C. glutamicum'', ''E. coli'', and the mouse genomes.  
:* [[Stephanopoulos:DNA microarrays | '''DNA microarrays''']] - We have developed full genome microarrays for ''Synechocystis'' Sp., and partial microarrays for ''C. glutamicum'', ''E. coli'', and the mouse genomes.  


:* [[Stephanopoulos Lab:Bioreaction network analysis | '''Bioreaction network analysis''']]
:* [[Stephanopoulos:Bioreaction network analysis | '''Bioreaction network analysis''']]


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Latest revision as of 15:30, 17 July 2007

Stephanopoulos Lab logo

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Research

Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:

  1. The modification of biochemical pathways inside cells, and
  2. The rigorous evaluation of the resulting cellular phenotypes.


Our most recent research has been focused on the following topics:


To accomplish the above goals we make use of a diverse array of scientific tools and methods, many of which have also become areas of research for our group:

  • Bioinformatics and Systems Biology - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
  • DNA microarrays - We have developed full genome microarrays for Synechocystis Sp., and partial microarrays for C. glutamicum, E. coli, and the mouse genomes.
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