Sriram Kosuri

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Personal

Sri at work
Sri at work

Bio

I am curently a postdoc in George Church's lab in the Department of Genetics at Harvard Medical School and the Wyss Institute. From September 2007 to February 2009, I worked at a small Cambridge-area startup called Joule Biotechnologies. I am also on the Board of Directors for OpenWetWare. I previously did a short postdoctoral stint in Mike Laub's lab working on cell cycle in Caulobacter crescentus. Prior to the Laub lab, I was a graduate student in Drew Endy's lab and worked on understanding the development of a simple virus (T7) that infects E. coli. As an undergraduate at UC Berkeley, I worked with Adam Arkin, Dale Kaiser, and Roy Welch on modeling traveling wave formation in M. xanthus.

Science

Interests

  • Developing technologies on making biology easier to engineer.
  • Enabling the design, construction, and use of biological organisms for the purposes of further scientific understanding; keeping extremely aware of the use of engineered biological organisms for other purposes.
  • Understanding those aspects of biological design that allow for certain robust features of development in the face of large intrinsic and extrinsic variation specifically on non-evolutionary time-scales (I am currently giving up on the past. That may change in the future.).
  • Property rights as related to biological information and organisms; understanding and reforming current and future frameworks; I really like these people
  • OpenWetWare of course!

Past Projects

Rebuilding T7

TABASCO -- A single molecule base-pair resolved gene expression simulator

Measure and Models of T7 Infection

How does T7 deal with Uncertainty

T7.2 Tests

Publications

Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips
Sriram Kosuri, Nikolai Eroshenko, Emily LeProust, Michael Super, Jeffrey Way, Jin Billy Li,George Church
Nature Biotechnology (2010) doi:10.1038/nbt.1716

Refactoring bacteriophage T7
Leon Y. Chan, Sriram Kosuri and Drew Endy
Molecular Systems Biology 13 September 2005 DOI:10.1038/msb4100025
URL PDF reprint News & Views October 2004 version

TABASCO: A single molecule, base-pair resolved gene expression simulator
Sriram Kosuri, Jason Kelly and Drew Endy
BMC Bioinformatics 2007, 8:480 doi:10.1186/1471-2105-8-480
URL

Interesting Stuff

The beginnings of a blog.

See my interesting stuff page

Post-doctoral Fellowships

A failed Research Plan for a job at Harvard's CGR

My Thesis!

My contributions to OWW

Sriram Kosuri/temp

Contact

Phone: still waiting
OWW users: Post a message on my talk page, or send me an email.
Email:
Postal:
Harvard Medical School
Genetics Department
New Research Building (NRB) Rooms 232
77 Ave. Louis Pasteur
Boston, MA 02115 USA

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