Sriram Kosuri

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[[Image:Sri Kosuri.jpg|thumb|right|Sri at work]]
[[Image:Sri Kosuri.jpg|thumb|right|Sri at work]]
===Bio===  
===Bio===  
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I am curently a member of the [http://wyss.harvard.edu/viewpage/72/advanced-technology-team Advanced Technology Team] in the [http://wyss.harvard.edu/viewpage/101/synthetic-biology Synthetic Biology Platform] at the [http://wyss.harvard.edu/ Wyss Institute]. Starting in January 2014, I will be an Assistant Professor at [http://www.ucla.edu/ UCLA] in the [http://www.chemistry.ucla.edu/ Chemistry and Biochemistry Department]. I was a postdoc in [[User:Geochurch|George Church]]'s [[Church Lab|lab]] in the [http://genetics.med.harvard.edu/ Department of Genetics] at Harvard Medical School and the Wyss Institute from 2009-2011.  From 2007-2009, I was the first employee of a biofuel startup called [http://jouleunlimited.com/ Joule Unlimited].  I got my ScD in [http://web.mit.edu/be/index.shtml Biological Engineering] at MIT in [[Drew Endy]]'s lab and worked on understanding the development of a simple virus (T7) that infects ''E. coli''. As an undergraduate in [http://bioeng.berkeley.edu/ Bioengineering] at UC Berkeley, I worked with [http://www.lbl.gov/~aparkin Adam Arkin], Dale Kaiser, and Roy Welch on modeling traveling wave formation in ''M. xanthus''.  I also co-founded OpenWetWare.   
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I am an Assistant Professor at [http://www.ucla.edu/ UCLA] in the [http://www.chemistry.ucla.edu/ Chemistry and Biochemistry Department]. I was previously  a member of the [http://wyss.harvard.edu/viewpage/72/advanced-technology-team Advanced Technology Team] in the [http://wyss.harvard.edu/viewpage/101/synthetic-biology Synthetic Biology Platform] at the [http://wyss.harvard.edu/ Wyss Institute]. I was a postdoc in [[User:Geochurch|George Church]]'s [[Church Lab|lab]] in the [http://genetics.med.harvard.edu/ Department of Genetics] at Harvard Medical School and the Wyss Institute from 2009-2011.  From 2007-2009, I was the first employee of a biofuel startup called [http://jouleunlimited.com/ Joule Unlimited].  I got my ScD in [http://web.mit.edu/be/index.shtml Biological Engineering] at MIT in [[Drew Endy]]'s lab and worked on understanding the development of a simple virus (T7) that infects ''E. coli''. As an undergraduate in [http://bioeng.berkeley.edu/ Bioengineering] at UC Berkeley, I worked with [http://www.lbl.gov/~aparkin Adam Arkin], Dale Kaiser, and Roy Welch on modeling traveling wave formation in ''M. xanthus''.  I also co-founded OpenWetWare.   
==Science==
==Science==
===Publications===
===Publications===
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'''Causes and effects of N-terminal codon bias in bacterial genes'''<br>
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[[User:Daniel_Goodman|Daniel B Goodman]], [[George_Church|George M Church]], [[Sriram Kosuri]]<br>
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''Science'', (2013) [http://dx.doi.org/10.1126/science.1241934 doi:10.1126/science.1241934]
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'''Probing the Limits of Genetic Recoding in Essential Genes'''<br>
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Marc Lajoie*, [[Sriram Kosuri]]*, Joshua Mosberg, Christopher Gregg, Di Zhang, [[George_Church|George M Church]]<br>
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''Science'', (2013) [http://dx.doi.org/10.1126/science.1241460 doi:10.1126/science.1241460]
'''Composability of regulatory sequences controlling transcription and translation in ''E. coli'''''<br>
'''Composability of regulatory sequences controlling transcription and translation in ''E. coli'''''<br>
[[Sriram Kosuri]]*, [[User:Daniel_Goodman|Daniel B Goodman]]*, [[User:Guillaume_Cambray|Guillaume Cambray]], Vivek K Mutalik, Yuan Gao, [[User:Aparkin|Adam P. Arkin]], [[User:Endy|Drew Endy]], [[George_Church|George M Church]]<br>
[[Sriram Kosuri]]*, [[User:Daniel_Goodman|Daniel B Goodman]]*, [[User:Guillaume_Cambray|Guillaume Cambray]], Vivek K Mutalik, Yuan Gao, [[User:Aparkin|Adam P. Arkin]], [[User:Endy|Drew Endy]], [[George_Church|George M Church]]<br>
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''Proc Natl Acad Sci USA'', [http://dx.doi.org/10.1073/pnas.1301301110 doi:10.1073/pnas.1301301110]
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''PNAS'', (2013) [http://dx.doi.org/10.1073/pnas.1301301110 doi:10.1073/pnas.1301301110]
'''CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering'''<br>
'''CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering'''<br>
Prashant Mali, John Aach, P Benjamin Stranges, Kevin M Esvelt, Mark Moosburner, [[Sriram Kosuri]], Luhan Yang, [[George_Church|George M Church]]<br>
Prashant Mali, John Aach, P Benjamin Stranges, Kevin M Esvelt, Mark Moosburner, [[Sriram Kosuri]], Luhan Yang, [[George_Church|George M Church]]<br>
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''Nature Biotechnology'', [http://dx.doi.org/10.1038/nbt.2675 doi:10.1038/nbt.2675]
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''Nature Biotechnology'', (2013) [http://dx.doi.org/10.1038/nbt.2675 doi:10.1038/nbt.2675]
'''Next-Generation Digital Information Storage in DNA'''<br>
'''Next-Generation Digital Information Storage in DNA'''<br>

Revision as of 11:44, 5 January 2014

Contents

Personal

Sri at work
Sri at work

Bio

I am an Assistant Professor at UCLA in the Chemistry and Biochemistry Department. I was previously a member of the Advanced Technology Team in the Synthetic Biology Platform at the Wyss Institute. I was a postdoc in George Church's lab in the Department of Genetics at Harvard Medical School and the Wyss Institute from 2009-2011. From 2007-2009, I was the first employee of a biofuel startup called Joule Unlimited. I got my ScD in Biological Engineering at MIT in Drew Endy's lab and worked on understanding the development of a simple virus (T7) that infects E. coli. As an undergraduate in Bioengineering at UC Berkeley, I worked with Adam Arkin, Dale Kaiser, and Roy Welch on modeling traveling wave formation in M. xanthus. I also co-founded OpenWetWare.

Science

Publications

Causes and effects of N-terminal codon bias in bacterial genes
Daniel B Goodman, George M Church, Sriram Kosuri
Science, (2013) doi:10.1126/science.1241934

Probing the Limits of Genetic Recoding in Essential Genes
Marc Lajoie*, Sriram Kosuri*, Joshua Mosberg, Christopher Gregg, Di Zhang, George M Church
Science, (2013) doi:10.1126/science.1241460

Composability of regulatory sequences controlling transcription and translation in E. coli
Sriram Kosuri*, Daniel B Goodman*, Guillaume Cambray, Vivek K Mutalik, Yuan Gao, Adam P. Arkin, Drew Endy, George M Church
PNAS, (2013) doi:10.1073/pnas.1301301110

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
Prashant Mali, John Aach, P Benjamin Stranges, Kevin M Esvelt, Mark Moosburner, Sriram Kosuri, Luhan Yang, George M Church
Nature Biotechnology, (2013) doi:10.1038/nbt.2675

Next-Generation Digital Information Storage in DNA
George M. Church, Yuan Gao, Sriram Kosuri
Science (2012) doi:10.1126/science.1226355

When It Rains, It Pores
Sriram Kosuri & A. Michael Sismour
ACS Synthetic Biology (2012) doi:10.1021/sb300015f

Gene Assembly from Chip-Synthesized Oligonucleotides
Nikolai Eroshenko*, Sriram Kosuri*, Adam H Marblestone, Nicholas Conway, & George Church
Current Protocols in Chemical Biology (2012) doi:10.1002/9780470559277.ch110190

Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
Feng Zhang*, Le Cong*, Simona Lodato, Sriram Kosuri, George Church & Paola Arlotta
Nature Biotechnology (2011) doi:10.1038/nbt.1775

Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips
Sriram Kosuri*, Nikolai Eroshenko*, Emily LeProust, Michael Super, Jeffrey Way, Jin Billy Li & George Church
Nature Biotechnology (2010) 28:1295 doi:10.1038/nbt.1716 News & Views, Cover Art

TABASCO: A single molecule, base-pair resolved gene expression simulator
Sriram Kosuri, Jason Kelly and Drew Endy
BMC Bioinformatics 2007, 8:480 doi:10.1186/1471-2105-8-480
URL

Refactoring bacteriophage T7
Leon Y. Chan*, Sriram Kosuri* and Drew Endy
Molecular Systems Biology 13 September 2005 DOI:10.1038/msb4100025
URL PDF reprint News & Views October 2004 version


Contact

Phone: 617-432-8283
OWW users: Post a message on my talk page, or send me an email.
Email:
Postal:
Wyss Institute
CLSB 508-7
3 Blackfan Circle
Boston, MA 02115 USA

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