Publications
Reviewed Journal Publications
- Hawkins KM and Smolke CD. Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. Nat Chem Biol. 2008 Sep;4(9):564-73. DOI:10.1038/nchembio.105 | PubMed ID:18690217 | HubMed [hawkins2]
- Win MN and Smolke CD. A modular and extensible RNA-based gene-regulatory platform for engineering cellular function. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14283-8. DOI:10.1073/pnas.0703961104 | PubMed ID:17709748 | HubMed [win2]
- Win MN, Klein JS, and Smolke CD. Codeine-binding RNA aptamers and rapid determination of their binding constants using a direct coupling surface plasmon resonance assay. Nucleic Acids Res. 2006;34(19):5670-82. DOI:10.1093/nar/gkl718 | PubMed ID:17038331 | HubMed [win]
- Hawkins KM and Smolke CD. The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae. J Biol Chem. 2006 May 12;281(19):13485-13492. DOI:10.1074/jbc.M512317200 | PubMed ID:16524886 | HubMed [hawkins]
- Pfleger BF, Pitera DJ, Smolke CD, and Keasling JD. Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes. Nat Biotechnol. 2006 Aug;24(8):1027-32. DOI:10.1038/nbt1226 | PubMed ID:16845378 | HubMed [pfleger]
- Bayer TS and Smolke CD. Programmable ligand-controlled riboregulators of eukaryotic gene expression. Nat Biotechnol. 2005 Mar;23(3):337-43. DOI:10.1038/nbt1069 | PubMed ID:15723047 | HubMed [bayer]
- Isaacs FJ and Collins JJ. Plug-and-play with RNA. Nat Biotechnol. 2005 Mar;23(3):306-7. DOI:10.1038/nbt0305-306 | PubMed ID:15765083 | HubMed [isaacs]
- Smolke CD and Keasling JD. Effect of gene location, mRNA secondary structures, and RNase sites on expression of two genes in an engineered operon. Biotechnol Bioeng. 2002 Dec 30;80(7):762-76. DOI:10.1002/bit.10434 | PubMed ID:12402322 | HubMed [smolke1]
- Smolke CD and Keasling JD. Effect of copy number and mRNA processing and stabilization on transcript and protein levels from an engineered dual-gene operon. Biotechnol Bioeng. 2002 May 20;78(4):412-24. DOI:10.1002/bit.10218 | PubMed ID:11948448 | HubMed [smolke2]
- Smolke CD, Khlebnikov A, and Keasling JD. Effects of transcription induction homogeneity and transcript stability on expression of two genes in a constructed operon. Appl Microbiol Biotechnol. 2001 Dec;57(5-6):689-96. DOI:10.1007/s002530100812 | PubMed ID:11778879 | HubMed [smolke3]
- Smolke CD, Martin VJ, and Keasling JD. Controlling the metabolic flux through the carotenoid pathway using directed mRNA processing and stabilization. Metab Eng. 2001 Oct;3(4):313-21. DOI:10.1006/mben.2001.0194 | PubMed ID:11676567 | HubMed [smolke4]
- Smolke CD, Carrier TA, and Keasling JD. Coordinated, differential expression of two genes through directed mRNA cleavage and stabilization by secondary structures. Appl Environ Microbiol. 2000 Dec;66(12):5399-405. DOI:10.1128/AEM.66.12.5399-5405.2000 | PubMed ID:11097920 | HubMed [smolke5]
All Medline abstracts: PubMed | HubMed
Non-Peer-Reviewed Publications
- Win MN and Smolke CD. RNA as a versatile and powerful platform for engineering genetic regulatory tools. Biotechnol Genet Eng Rev. 2007;24:311-46. DOI:10.1080/02648725.2007.10648106 | PubMed ID:18059640 | HubMed [win3]
- Bio FAB Group, Baker D, Church G, Collins J, Endy D, Jacobson J, Keasling J, Modrich P, Smolke C, and Weiss R. Engineering life: building a fab for biology. Sci Am. 2006 Jun;294(6):44-51. DOI:10.1038/scientificamerican0606-44 | PubMed ID:16711359 | HubMed [baker]
All Medline abstracts: PubMed | HubMed
- Smolke, C. 2005. Molecular switches for cellular sensors. Engineering and Applied Science 4, 28-37
- Martin, V.J.J., Smolke, C.D., Keasling, J.D. (2002) Redesigning cells for the production of complex organic molecules. ASM News 68, 336-343.
Books and Book Chapters
- Smolke, C.D., editor (2006) Metabolic Engineering Protocols: Synthesis and Design Strategies. In: Walker J, series ed., Methods in Molecular Biology. Totawa: Humana Press. In preparation.
- Smolke, C.D., editor (2006) Metabolic Engineering Protocols: Analysis and Characterization. In: Walker J, series ed., Methods in Molecular Biology. Totawa: Humana Press. In preparation.
- Smolke, C.D., editor (2006) Handbook for Metabolic Pathway Engineering. San Diego: CRC Press. In preparation.
- Smolke, C.D., Martin, V.J.J., Keasling, J.D. (2004) Tools for metabolic engineering in Escherichia coli. In: Baneyx, F., editor. Expression Technologies. U.K.: Horizon Scientific Press.
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