Smolke:Journal Club

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Selected topic May 10 J-club: Riboswitches and alternative splicing [1] Possible topics Genetic circuits in action [2] Modular protein switches [3] In vivo RNA measurements [4] Tight control of gene expression via a circuit of RNAi and repressor proteins[] Papers Cheah MT, Wachter A, Sudarsan N, and Breaker RR. Control of alternative RNA splicing and gene expression by eukaryotic riboswitches. Nature. 2007 May 24;447(7143):497-500. DOI:10.1038/nature05769 | Süel GM, Kulkarni RP, Dworkin J, Garcia-Ojalvo J, and Elowitz MB. Tunability and noise dependence in differentiation dynamics. Science. 2007 Mar 23;315(5819):1716-9. DOI:10.1126/science.1137455 | Sallee NA, Yeh BJ, and Lim WA. Engineering modular protein interaction switches by sequence overlap. J Am Chem Soc. 2007 Apr 18;129(15):4606-11. DOI:10.1021/ja0672728 | Valencia-Burton M, McCullough RM, Cantor CR, and Broude NE. RNA visualization in live bacterial cells using fluorescent protein complementation. Nat Methods. 2007 May;4(5):421-7. DOI:10.1038/nmeth1023 | Rinaudo K, Bleris L, Maddamsetti R, Subramanian S, Weiss R, and Benenson Y. A universal RNAi-based logic evaluator that operates in mammalian cells. Nat Biotechnol. 2007 Jul;25(7):795-801. DOI:10.1038/nbt1307 | Deans TL, Cantor CR, and Collins JJ. A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells. Cell. 2007 Jul 27;130(2):363-72. DOI:10.1016/j.cell.2007.05.045 |