Sarah Carratt 4.12.11: Difference between revisions
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**Define "simultaneously" | **Define "simultaneously" | ||
*Database represents a model built through experiments and literature | *Database represents a model built through experiments and literature | ||
==Clustering== | |||
**Define distance metric (this is what it means for two things to be close together) | **Define distance metric (this is what it means for two things to be close together) | ||
*Easily build matrix of closeness once distance is defined | *Easily build matrix of closeness once distance is defined | ||
Revision as of 09:44, 12 April 2011
Gene Regulation and Modeling
- Focused on measuring RNA and modeling dynamic behavior of proteins that RNA spins off
- High activity in RNA should mean high protein behavior
- Low activity in RNA should mean low protein behavior
Modeling in Network Construction
- Qualitative, not just quantitative/numbers
- Active genes working simultaneously → transcription factors
- Define "simultaneously"
- Database represents a model built through experiments and literature
Clustering
- Define distance metric (this is what it means for two things to be close together)
- Easily build matrix of closeness once distance is defined
- Clustering is more subtle
- time 1 graphed vs time 2...dot plot!
- two+ clusters that are distinct, separate based on where they fall..."an art"
