Role of Calcium in Seizure Activity: Difference between revisions
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•Currently, there is little information on the role of Calcium in a brain with seizure activity | •Currently, there is little information on the role of Calcium in a brain with seizure activity | ||
•Studies have been done showing that a calcium spike is | |||
•Studies have been done showing that a calcium spike is observe in neurons within a seizure model and also that these spikes are not seen in a brain exhibiting normal behavior | |||
•Our goal is to further study the role of Calcium by investigating the influx of Calcium into the pre-synaptic terminal (i.e. is the voltage gated Calcium channel constitutively open?) over time. | •Our goal is to further study the role of Calcium by investigating the influx of Calcium into the pre-synaptic terminal (i.e. is the voltage gated Calcium channel constitutively open?) over time. | ||
•Our methods will include the use of a calcium indicator dye (the same as used in the Okhi article) and two photon microscopy to reveal the presence of Calcium | •Our methods will include the use of a calcium indicator dye (the same as used in the Okhi article) and two photon microscopy to reveal the presence of Calcium | ||
Revision as of 05:25, 30 April 2008
Research Problems:
•Currently, there is little information on the role of Calcium in a brain with seizure activity
•Studies have been done showing that a calcium spike is observe in neurons within a seizure model and also that these spikes are not seen in a brain exhibiting normal behavior
•Our goal is to further study the role of Calcium by investigating the influx of Calcium into the pre-synaptic terminal (i.e. is the voltage gated Calcium channel constitutively open?) over time.
•Our methods will include the use of a calcium indicator dye (the same as used in the Okhi article) and two photon microscopy to reveal the presence of Calcium
Background:
Two-photon Imaging of Synaptic Plasticity and Pathology in the Living Mouse Brain Grutzendler et. al. Two-photon microscopy is used to study the neuronal structure of animal models of neurodegeneration, brain injury and cerebrovascular disease
Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex. Ohki et. al.
Employ calcium sensing to reveal the micro-architecture in the visual cortex of the brains of rats and cats
In vivo imaging of seizure activity in a novel developmental seizure model. Hewapathirane et. al.
Characterize an in vivo model of seizures in Xenopus laevis tadpole – allowing direct examination of seizure activist and seizure induced effects on neuronal development
