Robert Werdehausen

Contact information

Dr. Robert Werdehausen (M.D.) - Staff Anesthesiologist

• Departmental address:
  

Department of Anesthesiology, University Hospital Düsseldorf
Building 12.42, Moorenstr. 5, 40225 Düsseldorf, Germany

• Laboratory address (preferred mail address):
  

Experimental Anesthesiology Laboratory, Heinrich-Heine-University of Düsseldorf
Building 23.02.01.R64, Universitätsstr. 1, 40225 Düsseldorf, Germany
Email: robert.werdehausen@uni-duesseldorf.de
Phone: +49 211 81-13991
Fax: +49 211 81-13954

• Previous position (Post-doctorate research scientist):
  

Molecular Nociception Group (Head: Professor John N. Wood), Part of the London Pain Consortium (LPC)
Institute for Biomedical Research (WIBR), University College London (UCL)
Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom

Research interests

• Molecular mechanisms of pain perception
  

• Effects of local and general anesthetics on chronic pain
  

• Neurotoxicity of local and general anesthetics
  

• New techniques in regional anesthesia and pain medicine
  

Selected publications

• MicroRNA-1-associated effects of neuron-specific brain-derived neurotrophic factor gene deletion in dorsal root ganglia.
  Molecular and Cellular Neuroscience 2016; in press. Link to article

• Local Anesthetic-Induced Neurotoxicity.
  International Journal of Molecular Sciences 2016 Mar 4;17(3). PMID: 26959012 Pubmed abstract

• Pretreatment but not subsequent coincubation with midazolam reduces the cytotoxicity of temozolomide in neuroblastoma cells.
  BMC Anesthesiology 2015 Oct 17;15:151. PMID: 26475338 Pubmed abstract

• The lidocaine metabolite N-ethylglycine has antinociceptive effects in experimental inflammatory and neuropathic pain.
  PAIN 2015 Sep;156(9):1647-59. [Epub ahead of print] PMID: 25932687 Pubmed abstract

• Xenon does not increase heart rate-corrected cardiac QT-interval in volunteers and in patients free of cardiovascular disease.
  Anesthesiology 2015. Sep;123(3):542-7. PMID: 26164300 Pubmed abstract

• Expression changes of microRNA-1 and its targets Connexin 43 and brain-derived neurotrophic factor in the peripheral nervous system of chronic neuropathic rats.
  Molecular Pain 2015 Jun 26;11:39. PMID: 26111928 Pubmed abstract

• Glycine transporter GlyT1, but not GlyT2, is expressed in rat dorsal root ganglion - Possible implications for neuropathic pain.
  Neuroscience Letters 2015 Jul 23;600:213-9. PMID: 26101830 Pubmed abstract

• Regulation of Nav1.7: a conserved SCN9A natural antisense transcript expressed in dorsal root ganglia.
  PLOS ONE 2015. Jun 2;10(6):e0128830. PMID: 26035178 Pubmed abstract

• Mexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F Nav 1.7 sodium channels.
  British Journal of Pharmacology 2014 May 27. PMID: 24866741 Pubmed abstract

• Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats.
  Anesthesiology 2014 Jul;121(1):160-9. PMID: 24598217 Pubmed abstract

• Novel mutations mapping to the fourth sodium channel domain of Nav1.7 result in variable clinical manifestations of primary erythromelalgia.
  Neuromolecular Medicine 2013 Jan 6. PMID: 23292638 Pubmed abstract

• Neurological perspectives on voltage-gated sodium channels.
  Brain. 2012 Sep;135(Pt 9):2585-612. PMID: 22961543 Pubmed abstract

• Cardiovascular stability and unchanged muscle sympathetic activity during xenon anaesthesia: role of norepinephrine uptake inhibition.
  British Journal of Anaesthesia 2012 Sep 3. PMID: 22945969 Pubmed abstract

• Expression of spinal cord microRNAs in a rat model of chronic neuropathic pain.
  Neuroscience Letters 2012 Jan 11;506(2):281-6. PMID: 22138088 Pubmed abstract

• Lidocaine metabolites inhibit glycine transporter 1: a novel mechanism for the analgesic action of systemic lidocaine?
  Anesthesiology 2012 Jan;116(1):147-58. PMID: 22133759 Pubmed abstract

• Lipophilicity but not stereospecificity is a major determinant of local anaesthetic-induced cytotoxicity in human T-lymphoma cells.
  European Journal of Anaesthesiology 2012 Jan;29(1):35-41. PMID: 22012177 Pubmed abstract

• The influence of adjuvants used in regional anesthesia on lidocaine-induced neurotoxicity in vitro.
  Regional Anesthesia and Pain Medicine 2011 Sep-Oct;36(5):436-43. PMID: 21857277 Pubmed abstract

• The paravertebral lamina technique: a new regional anesthesia approach for breast surgery.
  Journal of Clinical Anesthesia 2011 Sep;23(6):443-50. PMID: 21752620 Pubmed abstract

• Midazolam activates the intrinsic pathway of apoptosis independent of benzodiazepine and death receptor signaling.
  Regional Anesthesia and Pain Medicine 2011 Jul-Aug;36(4):343-9. PMID: 21701267 Pubmed abstract

• Effect of continuous posttraumatic intrathecal nocistatin on the development of mechanical allodynia.
  Regional Anesthesia and Pain Medicine 2011 Jan-Feb;36(1):32-5. PMID: 21455086 Pubmed abstract

• Benzethonium increases the cytotoxicity of S(+)-ketamine in lymphoma, neuronal, and glial cells.
  Anesthesia & Analgesia 2010 Dec;111(6):1389-93. PMID: 20889936 Pubmed abstract

• Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells.
  British Journal of Anaesthesia 2010 Sep;105(3):347-54. PMID: 20659914 Pubmed abstract

• Apoptosis induction by different local anaesthetics in a neuroblastoma cell line.
  British Journal of Anaesthesia 2009 Nov;103(5):711-8. PMID: 19700777 Pubmed abstract

• Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons.
  Neuroscience 2009 Mar 31;159(3):1148-53. PMID: 19356695 Pubmed abstract

• Lidocaine protects from myocardial damage due to ischemia and reperfusion in mice by its antiapoptotic effects.
  Anesthesiology 2009 May;110(5):1041-9. PMID: 19352171 Pubmed abstract

• Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain.
  Neuroscience Letters 2008 Nov 21;445(3):214-9. PMID: 18793697 Pubmed abstract

• Skin temperature after interscalene brachial plexus blockade.
  Regional Anesthesia and Pain Medicine 2007 Nov-Dec;32(6):481-7. PMID: 18035293 Pubmed abstract

• Stimulating catheter as a tool to evaluate peripheral nerve function during hip rotationplasty.
  Regional Anesthesia and Pain Medicine 2007 Nov-Dec;32(6):528-32. PMID: 18035301 Pubmed abstract

• Lidocain induces apoptosis via the mitochondrial pathway independently of death receptor signaling.
  Anesthesiology. 2007 Jul;107(1):136-143. PMID: 17585225 Pubmed abstract

• Does interscalene catheter placement with stimulating catheters improve postoperative pain or functional outcome after shoulder surgery?
  A prospective, randomized and double-blinded trial.
  Anesthesia & Analgesia 2007 Feb;104(2):442-7. PMID: 17242107 Pubmed abstract

• Uniform distribution of skin-temperature increase after different regional-anesthesia techniques of the lower extremity.
  Regional Anesthesia and Pain Medicine 2007 Jan-Feb;32(1):73-8. PMID: 17196496 Pubmed abstract, PDF

• Sedation during spinal anaesthesia in infants.
  British Journal of Anaesthesia 2006 Sep;97(3):380-4. PMID: 16816395 Pubmed abstract

• Skin temperature during regional anesthesia of the lower extremity.
  Anesthesia & Analgesia 2006 Apr;102(4):1247-51. PMID: 16551932 Pubmed abstract, full text / letters

Memberships & Activities

• International Anesthesia Research Society (IARS)
• International Association for the Study of Pain (IASP)
• German Society for Anesthesiology and Intensive Care Medicine (DGAI)
• German Pain Society (Deutsche Schmerzgesellschaft e.V.)
• Secretary of the Subcommittee on Young Scientists (WAKWiN, DGAI)
• Selected mentee of the Mentoring Program for Junior Investigators in 2007 (DGAI)
• Selected mentor of the Mentoring Program for Junior Investigators in 2014 (DGAI)

Grants and awards

• 2nd price at the scientific presentation competition (German Anesthesiology Congress 2006)
• 3rd price at the scientific poster presentation (European Society of Regional Anaesthesia (ESRA) congress 2007)
• Research Fellowship of the German Research Foundation (DFG) 2011-2013
• DGAI Research Fellowship 2012 funded by the Fresenius Trust